期刊
CRITICAL CARE CLINICS
卷 36, 期 2, 页码 217-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2019.12.007
关键词
Endothelial glycocalyx; Shedding; Septic injury; Organ dysfunction; ARDS; AKI; Trauma
The endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on and within the vascular wall. Shedding of the EG plays a central role in many critical illnesses. Degradation of the EG is associated with increased morbidity and mortality. Certain illnesses and iatrogenic interventions can cause degradation of the EG. It is not known whether restitution of the EG promotes the survival of the patient. First trials that focus on the reorganization and/or restitution of the EG seem promising. Nevertheless, the step from bench to bedside is still a big one.
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