Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3
出版年份 2016 全文链接
标题
Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3
作者
关键词
-
出版物
BRAIN
Volume 139, Issue 11, Pages 2891-2908
出版商
Oxford University Press (OUP)
发表日期
2016-09-20
DOI
10.1093/brain/aww228
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease
- (2015) Andreia Teixeira-Castro et al. BRAIN
- Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism
- (2015) Andrea de Bartolomeis et al. CNS DRUGS
- Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice
- (2014) Wolfgang Boehmerle et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Presynaptic Calcium Channel Inhibition Underlies CB1 Cannabinoid Receptor-Mediated Suppression of GABA Release
- (2014) G. G. Szabo et al. JOURNAL OF NEUROSCIENCE
- The Global Epidemiology of Hereditary Ataxia and Spastic Paraplegia: A Systematic Review of Prevalence Studies
- (2014) Luis Ruano et al. NEUROEPIDEMIOLOGY
- Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease
- (2014) Anabela Silva-Fernandes et al. Neurotherapeutics
- Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
- (2014) Jessica R. Blount et al. Nature Communications
- Different ataxin-3 amyloid aggregates induce intracellular Ca 2+ deregulation by different mechanisms in cerebellar granule cells
- (2013) Francesca Pellistri et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Loss of D2 Dopamine Receptor Function Modulates Cocaine-Induced Glutamatergic Synaptic Potentiation in the Ventral Tegmental Area
- (2013) A. Madhavan et al. JOURNAL OF NEUROSCIENCE
- Toward RNAi Therapy for the Polyglutamine Disease Machado–Joseph Disease
- (2013) Maria do Carmo Costa et al. MOLECULAR THERAPY
- Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice
- (2013) Edgardo Rodríguez-Lebrón et al. MOLECULAR THERAPY
- H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse
- (2013) Hung-Li Wang et al. NEUROPHARMACOLOGY
- Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice
- (2013) Clévio Nóbrega et al. PLoS One
- Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease
- (2012) A. T. Simoes et al. BRAIN
- Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole
- (2012) T Ishima et al. Translational Psychiatry
- The Josephin Domain Determines the Morphological and Mechanical Properties of Ataxin-3 Fibrils
- (2011) Laura Masino et al. BIOPHYSICAL JOURNAL
- Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease
- (2011) Isabel Nascimento-Ferreira et al. BRAIN
- Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways
- (2011) Andreia Teixeira-Castro et al. HUMAN MOLECULAR GENETICS
- Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3
- (2011) V. G. Shakkottai et al. JOURNAL OF NEUROSCIENCE
- Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease
- (2011) Philipp Koch et al. NATURE
- Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease
- (2011) Carlos A. Matos et al. PROGRESS IN NEUROBIOLOGY
- Toward understanding Machado–Joseph disease
- (2011) Maria do Carmo Costa et al. PROGRESS IN NEUROBIOLOGY
- Balancing act: deubiquitinating enzymes in the nervous system
- (2011) Sokol V. Todi et al. TRENDS IN NEUROSCIENCES
- The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability
- (2010) Thomas M. Durcan et al. HUMAN MOLECULAR GENETICS
- A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein
- (2010) Ayumu Sugiura et al. MITOCHONDRION
- HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3
- (2010) An-Hsun Chou et al. NEUROBIOLOGY OF DISEASE
- Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
- (2009) Fiona M. Menzies et al. BRAIN
- New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado–Joseph disease)
- (2009) Udo Rüb et al. CURRENT OPINION IN NEUROLOGY
- Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation
- (2009) Zheng Ying et al. HUMAN MOLECULAR GENETICS
- Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects
- (2009) Mei Han et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability
- (2009) U. K. Jinwal et al. JOURNAL OF NEUROSCIENCE
- E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity
- (2008) Amit Mishra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3
- (2008) X. Chen et al. JOURNAL OF NEUROSCIENCE
- Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation
- (2008) An-Hsun Chou et al. NEUROBIOLOGY OF DISEASE
- Polyglutamine neurodegeneration: protein misfolding revisited
- (2008) Aislinn J. Williams et al. TRENDS IN NEUROSCIENCES
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started