Article
Infectious Diseases
Javier Martinez-Sanz, Sergio Serrano-Villar, Maria Jesus Vivancos, Rafael Rubio, Santiago Moreno
Summary: Modern ART has successfully achieved HIV RNA suppression and reduced drug-related toxicities. The main health concerns for HIV-positive individuals in high-income settings are now non-HIV related diseases. These comorbidities, common in the general population but with unique features in HIV patients, present a significant challenge in managing and normalizing the health of PLWH. In this study, HIV specialists review the literature and discuss the major challenges in HIV-associated comorbidities, providing insights and future strategies.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Public, Environmental & Occupational Health
Mingjun Chen, Jianhui Guo, Yawen Lin, Jialiang Xu, Yuduan Hu, Le Yang, Xingyan Xu, Li Zhu, Jungu Zhou, Zhiyu Zhang, Huangyuan Li, Shaowei Lin, Siying Wu
Summary: This study aimed to explore the association between multimorbidity and fertility history among middle-aged and elderly women in China. The results showed that high parity and early childbearing were significantly associated with an increased risk of multimorbidity, while late childbearing was associated with a reduced risk of multimorbidity. The association between fertility history and multimorbidity was influenced by age and urban-rural dual structure.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Xiao Zhang, Jason L. Sanders, Robert M. Boudreau, Alice M. Arnold, Jamie N. Justice, Mark A. Espeland, George A. Kuchel, Nir Barzilai, Lewis H. Kuller, Oscar L. Lopez, Stephen B. Kritchevsky, Anne B. Newman
Summary: By analyzing the relationships between multiple biomarkers and mortality, a biomarker index (BI) was found to be significantly associated with the composite outcome of death and chronic disease. It may serve as a practical intermediate phenotype for interventions aiming to modify the course of aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Julian C. Hong, Elizabeth R. Hauser, Thomas S. Redding, Kellie J. Sims, Ziad F. Gellad, Meghan C. O'Leary, Terry Hyslop, Ashton N. Madison, Xuejun Qin, David Weiss, A. Jasmine Bullard, Christina D. Williams, Brian A. Sullivan, David Lieberman, Dawn Provenzale
Summary: The study used a directed network graph to analyze comorbidities in a cohort of healthy veterans undergoing screening colonoscopy, identifying relationships between chronic diseases and visualizing the development of comorbidities over time. Top hub diseases included ischemic heart disease, while top authority diagnoses were acute kidney failure and hypertensive chronic kidney failure. The findings may help prioritize healthcare strategies and personalized care for aging veteran populations.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Rifqah Abeeda Roomaney, Brian van Wyk, Victoria Pillay-van Wyk
Summary: With older adults living longer with HIV, the incidence of HIV comorbidities is on the rise. A study conducted in South Africa found that older adults (50 years and older) with HIV were four times more likely to have comorbidities compared to younger adults. Being female and living in an urban area were factors associated with higher odds of HIV comorbidity. Comprehensive healthcare is necessary for older adults with HIV to address multiple conditions and maximize the benefits of HIV therapies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Sha Hua, Bomin Lv, Zeping Qiu, Zhuojin Li, Zhiyan Wang, Yanjia Chen, Yanxin Han, Katherine L. Tucker, Hao Wu, Wei Jin
Summary: This study aimed to identify microbial signatures that contribute to the shared etiologies between chronic heart failure (CHF), type 2 diabetes, and chronic kidney disease. The serum levels of 151 microbial metabolites were measured in 260 individuals from the Risk Evaluation and Management of heart failure cohort, and it was found that those metabolites varied by an order of 10(5) fold. Key microbial metabolite-based risk scores were superior in CHF prognosis than the traditional Framingham or Get with the Guidelines-Heart Failure risk scores. Interactive visualization of these specific metabolite-disease links is available on our omics data server ().
EMBO MOLECULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Win Min Han, Tanakorn Apornpong, Sivaporn Gatechompol, Sasiwimol Ubolyam, Pairoj Chattranukulchai, Lalita Wattanachanya, Sarawut Siwamogsatham, Stephen J. Kerr, Kristine M. Erlandson, Anchalee Avihingsanon
Summary: In this study, predictors of novel aging markers PhenoAge and PAA in people living with HIV were evaluated, with male sex, smoking, diabetes, hypertension, frailty, and high IL-6 levels independently associated with higher PAA. The PhenoAge marker showed better discrimination for frailty compared to chronological age alone, indicating its potential usefulness in identifying high-risk PLWH within a similar chronological age group.
Article
Rheumatology
Maria A. Stevens, Hayley J. Dykhoff, Vanessa L. Kronzer, Elena Myasoedova, John M. Davis, Ali Duarte-Garcia, Cynthia S. Crowson
Summary: Multimorbidity has a greater impact on women with RA, while men are more likely to have cardiovascular-related conditions. These findings suggest that research, clinical practice, and policies related to rheumatic diseases should take into account the variation in care needs by sex and gender.
Article
Cell Biology
Helen C. Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D. Hingorani, Andreas Beyer, Linda Partridge
Summary: This study found that interventions in the aging process can confer resistance to multiple age-related diseases in laboratory animals. By analyzing literature abstracts and clinical data, the researchers discovered associations between age-related diseases and aging mechanisms in humans. They also identified specific mechanisms that are associated with diverse age-related diseases. This suggests that targeting these mechanisms could potentially prevent multimorbidity.
Article
Clinical Neurology
Hui Chen, Yaguan Zhou, Liyan Huang, Xiaolin Xu, Changzheng Yuan
Summary: This study found that both the burden of multimorbidity and its developmental trajectory are closely associated with the risk of later-life dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Psychology, Multidisciplinary
Luis Fernando Silva Castro-de-Araujo, Fanny Cortes, Noemia Teixeira de Siqueira Filha, Elisangela da Silva Rodrigues, Daiane Borges Machado, Jacyra Azevedo Paiva de Araujo, Glyn Lewis, Spiros Denaxas, Mauricio L. Barreto
Summary: This review investigated the association and pattern of association between certain mental disorders and non-psychiatric diseases. The results showed strong associations between depression, psychosis, and multimorbidity, but studies on the pattern of association had inconsistent results.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
Alexandra Foscolou, Christina Chrysohoou, Kyriakos Dimitriadis, Konstantina Masoura, Georgia Vogiatzi, Viktor Gkotzamanis, George Lazaros, Costas Tsioufis, Christodoulos Stefanadis
Summary: This study aimed to evaluate the sociodemographic, lifestyle, and clinical characteristics of Ikarian islanders and identify healthy aging trajectories of multimorbidity. The results showed that multimorbidity was negatively correlated with a healthy aging index (HAI), with a 20% lower odds of multimorbidity for every 10-unit increase in HAI. Multimorbidity trends in relation to HAI varied between men and women at different ages, converging only in the seventh decade of life.
Article
Nutrition & Dietetics
Sirasa Ruangritchankul, Chutima Sumananusorn, Jintana Sirivarasai, Wutarak Monsuwan, Piyamitr Sritara
Summary: In a cross-sectional study of 300 employees aged 60 and above in Thailand, it was found that females and individuals with education <=12 years had lower serum zinc levels. Moreover, there was a significant association between depression and low serum zinc levels, as well as an increase in serum zinc concentration with increasing serum albumin. Early detection of risk factors and management of depression and low serum albumin may help prevent low serum concentrations of zinc.
Article
Public, Environmental & Occupational Health
Andrew Wister, Lun Li, Carly Whitmore, Jennifer Ferris, Katarzyna Klasa, Igor Linkov
Summary: This study investigates the positive role of protective health behaviors on multimorbidity resilience among older adults with two or more chronic conditions. It found that smoking, satisfaction with sleep, appetite, and skipping meals were associated with resilience in the expected direction, highlighting the importance of modifiable health behaviors in affecting levels of multimorbidity resilience in older age.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster, I. Aprahamian
Summary: The frailty index (FI) independently predicted mortality, with the highest impact in individuals with endocrine, lung, or heart diseases. Both multimorbidity and specific chronic disease clusters were associated with an accelerated increase in frailty over time, highlighting the importance of initiating frailty prevention in middle age.
Article
Oncology
Claire Delacote, Solenne Delacour-Billon, Stephanie Ayrault-Piault, Anne-Delphine Tagri, Gwenaelle Rousseau, Melissa Vincent, Sophie Amosse, Cyrille Delpierre, Anne Cowppli-Bony, Florence Molinie
Summary: Despite universal access to cancer care, breast cancer survival remains lower in deprived areas in France. Intensification of prevention measures is important to reduce the occurrence of advanced breast cancer, which is responsible for the majority of breast cancer deaths. A better understanding of the remaining social disparities is crucial for implementing specific interventions.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Jeanne Sibiude, Jerome Le Chenadec, Laurent Mandelbrot, Alexandre Hoctin, Catherine Dollfus, Albert Faye, Eida Bui, Emmanuelle Pannier, Jade Ghosn, Valerie Garrait, Veronique Avettand-Fenoel, Pierre Frange, Josiane Warszawski, Roland Tubiana
Summary: Antiretroviral therapy initiated before pregnancy and continued throughout pregnancy can significantly reduce perinatal transmission of HIV. Factors such as not breastfeeding, infant prophylaxis, and maternal viral suppression near delivery play important roles in preventing transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Laura Waters, Lambert Assoumou, Ana Gonzalez-Cordon, Stefano Rusconi, Pere Domingo, Mark Gompels, Stephane de Wit, Francois Raffi, Christoph Stephan, Mar Masia, Jurgen Rockstroh, Christine Katlama, Georg M. N. Behrens, Graeme Moyle, Margaret Johnson, Julie Fox, Hans-Jurgen Stellbrink, Giovanni Guaraldi, Eric Florence, Stefan Esser, Jose M. Gatell, Anton Pozniak, Esteban Martinez
Summary: In the NEAT022 trial, virologically suppressed HIV patients at high cardiovascular risk switching from protease inhibitors to dolutegravir showed noninferior virological suppression and significant reductions in lipid and cardiovascular disease risk, regardless of immediate or delayed switching.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Romain Palich, Rachid Agher, Dimoke J. Wetshikoy, Lise Cuzin, Sophie Seang, Cathia Soulie, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Valerie Pourcher, Anne-Genevieve Marcelin, Lambert Assoumou, Christine Katlama
Summary: This study aims to explore the differences in antiretroviral therapy (ART) prescriptions between naive and virally suppressed HIV patients born in France and Sub-Saharan Africa. The findings suggest that the differences in ART prescriptions between these two groups cannot solely be explained by different clinical and virologic situations.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Letter
Dermatology
Agathe Nouchi, Cecile Brin, Abigail Martin, Marion Favier, Romain Palich, Yara Wakim, Ariane Gavaud, Sophie Seang, Marc-Antoine Valantin, Alexandre Bleibtreu, Sonia Burrel, Vincent Berot, Valerie Pourcher, Gentiane Monsel
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Infectious Diseases
Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Helene Laroche, Pascal Pugliese, Andre Cabie, Dat'AIDS Study Grp
Summary: This study analyzed the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years and its relationship with previous episodes of low-level viral load (LLVL). The results showed that LLVL was associated with VF, and even in the absence of subsequent failure, LLV episodes have a cost. Therefore, any viral load value above 50 copies/mL should lead to enhanced adherence counseling.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Laurent Mandelbrot, Roland Tubiana, Pierre Frange, Gilles Peytavin, Jerome Le Chenadec, Ana Canestri, Philippe Morlat, Cecile Brunet-Cartier, Jeanne Sibiude, Delphine Peretti, Veronique Chambrin, Amelie Chabrol, Eida Bul, Caroline Simon-Toulza, Lucie Marchand, Christelle Paul, Sandrine Delmas, Veronique Avettand-Fenoel, Josiane Warszawski, Monogest Study Grp
Summary: This study evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. The primary objective was to determine the proportion of patients maintaining a viral load (VL) of <50 copies/mL on darunavir/ritonavir monotherapy without needing treatment intensification. The results showed that nearly 10% of cases required treatment intensification, limiting the widespread use of darunavir/ritonavir maintenance monotherapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Health Care Sciences & Services
Baptiste Sellem, Basma Abdi, Minh Le, Roland Tubiana, Marc-Antoine Valantin, Sophie Seang, Luminita Schneider, Antoine Faycal, Gilles Peytavin, Cathia Soulie, Anne-Genevieve Marcelin, Christine Katlama, Valerie Pourcher, Romain Palich
Summary: In this observational study, researchers evaluated the effectiveness of administering bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) 5 or 4 days a week in maintaining viral suppression in people living with HIV. The study included 85 patients who started intermittent B/F/TAF between November 28, 2018, and July 30, 2020. The results showed a high success rate in terms of both virological success and strategy success, indicating that the intermittent dosing of B/F/TAF could effectively control HIV replication while reducing exposure to antiretroviral therapy (ART).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Virology
Nhu Ngoc Nguyen, Linda Houhamdi, Line Meddeb, Philippe Colson, Philippe Gautret
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Coline Mortier, Herve Tissot-Dupont, Florian Cardona, Christiane Bruel, Salima Lahouel, Hanane Lasri, Karim Bendamardji, Celine Boschi, Philippe Parola, Matthieu Million, Philippe Colson, Philippe Brouqui, Bernard La Scola, Jean-Christophe Lagier, Nadim Cassir
Summary: In the current global outbreak of mpox, the clinical presentation is poorly specific and reinforces the importance of microbiological confirmation. Symptomatic patients who test negative for the virus should undergo a broad differential diagnosis.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Virology
Philippe Colson, Bernard La Scola, Mamadou Beye, Jeremy Delerce, Didier Raoult, Jacques Fantini
Summary: The emergence of the Omicron BA.2.86 variant with 39 additional mutations in the spike protein is a major event in the genetic evolution of SARS-CoV-2. This study provides insights into the phylogeny, mutation positions and frequencies, and structural model of the spike protein in BA.2.86.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Erica Telford, Beatriz Grinsztejn, Inge Christoffer Olsen, Nicolas Pulik, France Mentre, Skerdi Haviari, Maxime Hentzien, Olivier Segeral, Miquel B. Ekkelenkamp, Dimie Ogoina, Nathalie Strub-Wourgaft, Alpha Diallo, Yazdan Yazdanpanah, Alexandra Calmy
Article
Multidisciplinary Sciences
Helene M. Roux, Amira Marouf, Jacques Dutrieux, Benedicte Charmeteau-De Muylder, Suzanne Figueiredo-Morgado, Veronique Avettand-Fenoel, Pelagia Cuvelier, Cecile Naudin, Fatma Bouaziz, Guillaume Geri, Anne Couedel-Courteille, Pierre Squara, Stefano Marullo, Remi Cheynier
Summary: Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. Genetic polymorphism that affects thymic output can modify SARS-CoV-2 immunity and disease severity. GG genotype is associated with stronger and long-lasting immune response and less severe lung involvement.
Article
Infectious Diseases
Kevin Bouiller, Houssein Gbaguidi-Haore, Didier Hocquet, Thomas Crepin, Daniel Wendling, Sophie Borot, Catherine Chirouze, Xavier Bertrand
Summary: This study aimed to evaluate the effects of replacing ceftriaxone with cefotaxime on the incidence of third generation cephalosporin-resistant Enterobacterales (3GC-RE). The results showed that replacing ceftriaxone with cefotaxime reduced the occurrence of 3GC-RE isolates.
INFECTIOUS DISEASES NOW
(2024)
Article
Primary Health Care
Laetitia Gimenez, Michelle Kelly-Irving, Cyrille Delpierre, Marie-Eve Rouge-Bugat, Benoit Lepage, Thierry Lang
Summary: This study analysed the differences in patient-primary care physician interaction between overweight or obese patients and normal-weight patients. The results showed that disagreement between patients and physicians was more prominent in the area of weight and lifestyle advice for overweight patients. These disagreements could have a negative impact on the quality of the patient-physician relationship.