Article
Biochemistry & Molecular Biology
Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Noriko Nagi-Miura, Yasuo Miyagi, Yasuhiko Itoh, Yosuke Ishii
Summary: This study found that Kawasaki disease may promote the development of atherosclerosis in adulthood. Long-term treatment with HMG-CoA inhibitors (statins) effectively suppressed the occurrence of atherosclerosis and inflammatory cell infiltration. Therefore, statin treatment may be used for secondary prevention of cardiovascular events during the chronic phase of Kawasaki disease.
Review
Cell Biology
Peter T. Wright, Julia Gorelik, Sian E. Harding
Summary: Research in cardiovascular biology has provided significant insights into the beta-adrenoceptor family in the past fifteen years, shifting pharmacological focus to structural micro-domains. While links between ion channels and beta AR are assumed, there are relatively few studies specifically examining the direct link between structural remodeling and electrical remodeling.
Article
Immunology
Rebecca A. Porritt, Carol Chase Huizar, Edward J. Dick, Shyamesh Kumar, Renee Escalona, Angela C. Gomez, Stefani Marek-Iannucci, Magali Noval Rivas, Jean Patterson, Thomas G. Forsthuber, Moshe Arditi, Mark Gorelik
Summary: Proteomic analysis of cardiac tissues showed differential protein expression in KD-like, control, and anakinra-treated cardiac tissue. STAT3 and IL-6 were upregulated with LCWE injection and normalized by anakinra treatment, but they were not essential for disease development, suggesting they may be bystanders of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Mia DelVechio, Juliano Alves, Alina Z. Saiyid, Shubhnita Singh, Joseph Galley, Wanessa M. C. Awata, Rafael M. Costa, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento
Summary: This study investigates the relationship between Kawasaki disease and vascular function and blood pressure using a murine model. The findings suggest that Kawasaki disease may be associated with vascular dysfunction, which may be dependent on COX-derived products, oxidant properties, and NO bioavailability. Vascular smooth muscle cells may play an important role in the development of vascular dysfunction and vasculitis via the Toll-like receptor 4 pathway. However, the CAWS model seems inappropriate for studying Kawasaki disease-associated shock. Further studies are needed to understand whether vascular dysfunction and COXs are triggers for vasculitis.
Article
Biology
Alexandra Polyak, Leila Topal, Noemi Zombori-Toth, Noemi Toth, Janos Prorok, Zsofia Kohajda, Szilvia Deri, Vivien Demeter-Haludka, Peter Hegyi, Viktoria Venglovecz, Gergely Agoston, Zoltan Husti, Peter Gazdag, Jozefina Szlovak, Tamas Arpadffy-Lovas, Muhammad Naveed, Annamaria Sarusi, Norbert Jost, Laszlo Virag, Norbert Nagy, Istvan Baczko, Attila S. Farkas, Andras Varro
Summary: Exercise in elite athletes can cause cardiac arrhythmias and sudden cardiac death. A study on a dog model showed that chronic training induces electrophysiological remodeling and increases susceptibility to ventricular arrhythmias. These changes were associated with increased fibrosis and enhanced expression of HCN4 protein.
Article
Multidisciplinary Sciences
Eisuke Suganuma, Satoshi Sato, Satoko Honda, Atsuko Nakazawa
Summary: The study demonstrated that all-trans-retinoic acid (atRA) has a significant inhibitory effect on coronary artery stenosis in patients with Kawasaki disease. By suppressing smooth muscle cell migration, atRA effectively alleviates CA inflammation and reduces the incidence of CA stenosis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Yoshinori Abe, Ikuno Uehara, Makoto Watanabe, Yoshiaki Hashimoto, Yasuo Miyagi, Noriko Nagi-Miura, Nobuyuki Tanaka, Yosuke Ishii
Summary: Chronic inflammation caused by Kawasaki disease may contribute to vascular cellular senescence and endothelial cell damage, which can lead to atherosclerosis in young adults. This study found that statins can restore vascular endothelial cell function by promoting the expression of endothelial nitric oxide synthase (eNOS), and may be used to prevent cardiovascular events during the chronic phase of Kawasaki disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Susanna T. E. Cooper, Joseph D. Westaby, Zoe H. R. Haines, Giles O. Malone, Mary N. Sheppard, Daniel N. Meijles
Summary: This study compares human and mouse models to investigate the pathological remodeling process and timeline of hypertensive heart disease. The findings suggest that perivascular fibrosis plays a significant role in disease progression in humans, while cardiomyocyte hypertrophy has less impact. In addition, the study reveals that CD45+ inflammatory cell infiltration is an early response event preceding myocardial inflammation and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Deborah Marciano, Brooke R. Staveland, Jack J. Lin, Ignacio Saez, Ming Hsu, Robert T. Knight
Summary: Social decision making requires the integration of reward valuation and social cognition systems, both dependent on the orbitofrontal cortex (OFC). This study recorded intracranial activity from the OFC of ten patients making choices in a social context and found that OFC high-frequency activity encodes self-reward, the social counterpart's reward, and the type of reward inequity being experienced. The study also revealed that the encoding in the OFC can switch rapidly and reversibly depending on the type of reward inequity.
Article
Multidisciplinary Sciences
Xiaoxue Ma, Qingshu Meng, Shiyu Gong, Shanshan Shi, Xiaoting Liang, Fang Lin, Li Gong, Xuan Liu, Yinzhen Li, Mimi Li, Lu Wei, Wei Han, Leng Gao, Zhongmin Liu, Xiaohui Zhou
Summary: Excessive and chronic inflammation after myocardial infarction (MI) causes heart failure through cardiac fibrosis and ventricular remodeling. IL-27, mainly produced by cardiac macrophages, is found to be associated with aggravated fibrosis and cardiac dysfunction post MI. IL-27 activates the JAK/STAT signaling pathway in cardiac fibroblasts (CFs) and promotes their proliferation, migration, and extracellular matrix (ECM) production induced by angiotensin II (Ang II).These findings suggest that IL-27 plays a critical role in chronic inflammation-mediated ventricular remodeling and fibrosis.
Article
Biochemistry & Molecular Biology
Youming Chen, Lan Wang, Shixing Huang, Jiangfeng Ke, Qing Wang, Zhiwen Zhou, Wei Chang
Summary: Lutein may reduce the risk of cardiac remodeling and heart failure by suppressing IL-11 expression, showing potential as a treatment option.
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Syed Raza Mahmood, Xin Xie, Nadine Hosny El Said, Tomas Venit, Kristin C. Gunsalus, Piergiorgio Percipalle
Summary: The study demonstrates that changes in beta-actin levels can influence chromatin structure and 3D genome architecture, as well as the chromatin remodeling activities of BAF and polycomb proteins in mouse embryonic fibroblasts.
NATURE COMMUNICATIONS
(2021)
Article
Rheumatology
Dimitris Veroutis, Ourania D. Argyropoulou, Andreas Goules, Konstantinos Kambas, Dimitris Anastasios Palamidas, Konstantinos Evangelou, Sophia Havaki, Aikaterini Polyzou, Dimitrios Valakos, Evangelia Xingi, Elli Karatza, Kyriaki A. Boki, Alberto Cavazza, Christos Kittas, Dimitris Thanos, Caterina Ricordi, Chiara Marvisi, Francesco Muratore, Elena Galli, Stefania Croci, Carlo Salvarani, Vassilis G. Gorgoulis, Athanasios G. Tzioufas
Summary: Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Maolin Ma, Qipeng Sun, Xiujie Li, Gengguo Deng, Yannan Zhang, Zhe Yang, Fei Han, Zhengyu Huang, Youqiang Fang, Tao Liao, Qiquan Sun
Summary: This study investigated the effect of IL-6/IL-6R signaling blockade on acute antibody-mediated rejection (AAMR) and found that the blockade significantly reduced graft injury and improved survival. Mechanistic research showed that the blockade decreased B cell numbers, inhibited antibody production and complement activation, and reduced inflammatory cell infiltration in allografts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Stefanie Marek-Iannucci, Asli D. Yildirim, Syed M. Hamid, Asli B. Ozdemir, Angela C. Gomez, Begum Kocaturk, Rebecca A. Porritt, Michael C. Fishbein, Takao Iwawaki, Magali Noval Rivas, Ebru Erbay, Moshe Arditi
Summary: This study found a causal relationship between endoplasmic reticulum stress and Kawasaki disease (KD) pathogenesis, and highlighted IRE1 RNase activity as a potential new therapeutic target.
Article
Immunology
Magali Noval Rivas, Rebecca A. Porritt, Mary Hongying Cheng, Ivet Bahar, Moshe Arditi
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop in relation to SARS-CoV-2 infection. MIS-C is characterized by systemic hyperinflammation and multiorgan involvement, with similarities to Kawasaki disease and toxic shock syndrome. Molecular analysis and immunosequencing studies have revealed the presence of SAg-like and neurotoxin-like structures in MIS-C, which may contribute to autoimmune responses and neurological symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Trevon Fuller, Tara Kerin, Ruth Cortado, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvea, Christianne Moreira, Maria Leticia Santos Cruz, Jose Henrique Pilotto, Ivete Gomes, Breno Santos, Taui Rocha, Priya R. Soni, Esau Joao, Myung Shin-Sim, Yvonne Bryson, Karin Nielsen-Saines
Summary: This study examines the development of HIV DNA levels and the effect on HIV antibodies in perinatally HIV-infected children after receiving cART treatment. The results show that there is no significant difference in HIV DNA levels at school age between children who received early or late cART initiation. Furthermore, a decrease in HIV antibodies is associated with long-term viral suppression.
Article
Pediatrics
Helen Pizzo, Priya R. R. Soni, Santhosh Nadipuram, Jonathan Garrison, Stanley C. C. Jordan, Dechu Puliyanda
Summary: This case series suggests favorable short-term outcomes with accepting SARS-CoV-2-positive donors for pediatric renal transplantation, after thorough evaluation of the donor's risk for transmission, assessing the recipient's serologic status to SARS-CoV-2, and considering pre-emptive measures to mitigate the risk for severe COVID-19 should the recipient acquire donor-derived SARS-CoV-2.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Immunology
Hironobu Kobayashi, Motoko Y. Kimura, Ichita Hasegawa, Eisuke Suganuma, Yuzuru Ikehara, Kazuhiko Azuma, Toshihiro Ito, Ryota Ebata, Yosuke Kurashima, Yohei Kawasaki, Yuki Shiko, Naoki Saito, Hirotaro Iwase, Youngho Lee, Magali Noval Rivas, Moshe Arditi, Masahiko Zuka, Hiromichi Hamada, Toshinori Nakayama
Summary: Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects children. The expression of Myl9, a protein involved in cellular contractility, is significantly increased during KD vasculitis, and Myl9 levels may serve as a useful biomarker for estimating inflammation and IVIG responsiveness in KD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Begum Kocaturk, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E. Lane, Debbie Moreira, Shuang Chen, Michael C. Fishbein, Rebecca A. Porritt, Bernardo S. Franklin, Magali Noval Rivas, Moshe Arditi
Summary: Kawasaki disease is the leading cause of acquired heart disease among children, and platelet activation plays an important role in its development. Changes in the expression of platelet-related genes were observed during acute Kawasaki disease. In a mouse model, injection of Lactobacillus casei cell wall extract (LCWE) increased platelet counts, formation of monocyte-platelet aggregates (MPAs), and the concentration of soluble P-selectin, thrombopoietin, and interleukin 6 (IL-6). Platelet depletion or treatment with an anti-CD42b antibody significantly reduced LCWE-induced cardiovascular lesions in the mouse model, indicating that platelet activation exacerbates the development of cardiovascular lesions in Kawasaki disease vasculitis.
Article
Rheumatology
Magali Noval Rivas, Moshe Arditi
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2023)
Review
Cell Biology
Asli E. Atici, Timothy R. Crother, Magali Noval Rivas
Summary: Cardiovascular diseases are a leading cause of death worldwide, and optimal mitochondrial function is crucial for the cardiovascular system. Mitochondrial quality control ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis, playing a role in cell survival and adaptation to environmental stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Hematology
Prasant Jena, Daiko Wakita, Angela C. Gomez, Thacyana T. Carvalho, Meena Narayanan, Youngho Lee, Patrice D. Cani, Willem M. De Vos, Shuang Chen, Timothy R. Crother, Kenichi Shimada
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Meeting Abstract
Immunology
Prasant K. Jena, Daiko Wakita, Angela C. Gomez, Thacyana T. Carvalho, Meena Narayanan, Youngho Lee, Patrice D. Cani, Willem M. de Vos, Suzanne Devkota, David M. Underhill, Shuang Chen, Kenichi Shimada, Timothy R. Crother, Moshe Arditi, Magali Noval Rivas
JOURNAL OF IMMUNOLOGY
(2022)
Article
Infectious Diseases
Demiana Sidrak, Jack Green, Pooja Nawathe, Margie Morgan, Priya R. Soni
Summary: Dog bites, especially in toddlers, can cause significant morbidity, with injuries to the head and face being common. There is ongoing clinical equipoise regarding standardized post-dog bite injury management. Research shows an interesting threefold increase in dog bites during the SARS-CoV-2 pandemic, suggesting a potential for further discovery of unique canine pathogens contributing to human infections.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Medicine, Research & Experimental
Daniella Rastelli, Ariel Robinson, Valentina N. Lagomarsino, Lynley T. Matthews, Rafla Hassan, Kristina Perez, William Dan, Peter D. Yim, Madison Mixer, Aleksandra Prochera, Amy Shepherd, Liang Sun, Kathryn Hall, Sarah Ballou, Anthony Lembo, Judy Nee, Meenakshi Rao
Summary: Functional gastrointestinal disorders (FGIDs) exhibit sex differences in incidence, symptoms, and treatment response. Lower levels of free testosterone were found in adults with irritable bowel syndrome (IBS), and it was inversely correlated with symptom severity. Depletion of gonadal androgens caused a deficit in gastrointestinal transit in mice, which could be rescued by restoring a single androgen hormone. Androgen receptors in a subset of enteric neurons became responsive during puberty and were required for normal colonic motility. These findings establish a role for gonadal androgens in bowel function regulation and link altered androgen levels with a common digestive disorder.
JOURNAL OF CLINICAL INVESTIGATION
(2022)