Article
Plant Sciences
Rui Tao, Erwei Liu, Xin Zhao, Lifeng Han, Bin Yu, Haoping Mao, Wenzhi Yang, Xiumei Gao
Summary: This study investigates the potential mechanisms of an herbal formula called Erzhi on benign prostatic hyperplasia (BPH). The formula contains compounds from Ligustri Lucidi Fructus and Ecliptae Herba, which have been shown to exhibit phytoestrogenic or phytoandrogenic activities. The results demonstrate that the formula and its active pharmaceutical ingredients have inhibitive effects on BPH by regulating the expression of certain genes related to BPH.
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Pharmacology & Pharmacy
Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao
Summary: Kaempferol has been identified as a natural compound that inhibits tumor development in androgenic related prostate cancer and suppresses testosterone-induced benign prostatic hyperplasia (BPH) via modulation of the androgen receptor function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Tian Fang, Ze-sheng Xue, Jia-xuan Li, Jia-kuan Liu, Di Wu, Mei-qian Li, Yu-ting Song, Shi-feng Yun, Jun Yan
Summary: The extract of Rauwolfia vomitoria significantly reduced prostate weight and proliferation markers in BPH rats, while also decreasing the expression levels of androgen receptor and its associated proteins. Compared to the reference drug, R. vomitoria extract did not significantly affect sperm count, suggesting it may be a promising therapeutic agent for BPH with milder side effects.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Tiziana Genovese, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Livia Interdonato, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri
Summary: The study revealed that ultra-micronized um-PEA/Baic can reduce prostate weight and DHT production in BPH-induced rats, while modulating apoptotic and inflammatory pathways as well as oxidative stress.
Article
Plant Sciences
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um
Summary: This study found that a water extract of Glycyrrhiza uralensis Fischer has potential therapeutic effects on BPH by inhibiting AR-5AR2 signaling and activating apoptosis signaling to reduce BPH development. Unlike finasteride, GUWE does not impact sperm count, suggesting lower toxicity and a safer alternative option for BPH treatment.
Article
Medicine, Research & Experimental
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: Excessively activated TGF-131 exacerbates BPH by triggering EMT and cell differentiation. HSP, a flavanone in citrus peels, shows safe anti-cancer activity and inhibits prostate cancer cell growth. This study explores the therapeutic effect of HSP in BPH models and reveals its underlying mechanisms. HSP inhibits prostate cell proliferation and reduces inflammatory and mesenchymal markers by blocking TGF-131 activation, providing evidence for a new therapeutic approach against BPH.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Subin Oh, Moon Ho Do, Jin A. Shin, Min Jee Lee, Hua Li, Su Yeon Cho, Jong-Moon Jeong
Summary: This study investigated the protective effects of a natural product mixture called BenPros on benign prostatic hyperplasia (BPH). BenPros exhibited inhibitory ability on the expression of androgen receptor, prostate-specific antigen, and 5 alpha-reductase protein, as well as anti-inflammatory effects. The mixture also reduced levels of hormones associated with BPH and showed regulatory effects on BPH markers, leading to a decrease in prostate size and epithelial thickness.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Junya Hata, Yuki Harigane, Kanako Matsuoka, Hidenori Akaihata, Kei Yaginuma, Satoru Meguro, Seiji Hoshi, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima
Summary: Benign prostatic hyperplasia (BPH) is a chronic proliferative disease mainly characterized by stromal proliferation. Although aging and androgen have been considered risk factors, recent studies suggest the involvement of androgen-independent factors, such as inflammation, in BPH development. In this study, whole-genome gene expression analysis using a stromal-dominant BPH rat model revealed activated immune response-related pathways and complement classical pathways. Moreover, the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. Understanding the role of androgen-independent factors, like immune responses, contributes to unraveling the pathogenesis of BPH and may lead to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Sha-sha Wang, Kai Li, Zhiwei Liu, Shukang Gui, Nian Liu, Xiangyun Liu
Summary: The study demonstrated that aerobic exercise could slow fat mass gain, improve BPH-related indicators, reduce blood lipid levels, and alleviate BPH symptoms in obese mice by regulating the AR/androgen/PI3K/AKT signaling pathway.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Eman M. Elbaz, Alshaymaa Darwish, Amany M. Gad, Amina A. S. Abdel Rahman, Maheera H. Safwat
Summary: This study aimed to investigate the therapeutic effect of Canagliflozin, a selective SGLT2 inhibitor, on BPH in elderly males. The results demonstrated that Cana can impede BPH progression by modulating miR-128b/EGFR/EGF and JAK2/STAT3 pathways and downregulating AR, cyclin D1, and PCNA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Article
Biochemistry & Molecular Biology
Datu Agasi Mohd Kamal, Siti Fatimah Ibrahim, Azizah Ugusman, Mohd Helmy Mokhtar
Summary: This study found aberrant expression of sex steroid receptors in polycystic ovary syndrome and demonstrated that Kelulut honey treatment can normalize the expression of these receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)