期刊
CHINESE CHEMICAL LETTERS
卷 31, 期 7, 页码 1859-1862出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.01.001
关键词
Chiral 4-substituted chromanes; Asymmetric hydrogenation; Excellent enantioselectivity; Gram-scale synthesis; Bisphosphine-thiourea ligand
资金
- National Natural Science Foundation of China [21432007, 21502145, 21602172]
- Wuhan Morning Light Plan of Youth Science and Technology [2017050304010307]
- Fundamental Research Funds for and the Central Universities [2042018kf0202]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]
- Science and Technology Innovation Committee of Shenzhen [KQTD 20150717103157174]
- SZDRC Discipline Construction Program
Rh/ZhaoPhos-catalyzed asymmetric hydrogenation of a series of (E)-2-(chroman-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities (up to 99% yield, 98% ee). Moreover, the gram-scale hydrogenation could be performed well in the presence of 0.02 mol% catalyst loading (TON = 5000), the hydrogenation product was easily converted to access other important compounds, which demonstrated the synthetic utility of this asymmetric catalytic methodology. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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