Article
Immunology
Liting Wu, Yanjian Yang, Along Gao, Jun Li, Jianmin Ye
Summary: The study found that tilapia anterior kidney (AK) leukocytes can be divided into two subsets of IgM(+) B cells: lymphoid (L) gate and granulocyte-monocyte/macrophage (G-M) subsets. The G-M gate IgM(+) cells resemble plasma-like cells, with high antibody-secreting, phagocytic, and antigen-presenting capacities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Yanhan Hou, Shasha Li, Hongyan Zhu, Mengxue Qiao, Xiaowen Sun, Guorong Li
Summary: This study systematically investigated the development and degeneration of the thymus and kidney in Nothobranchius guentheri fish and the effects of resveratrol on aging. The results showed that the thymus and kidney underwent distinct developmental changes at different stages of fish growth, and degeneration of the thymus and kidney occurred with age. Feeding resveratrol ameliorated the aging-related changes in the kidney and thymus and reduced inflammation. This study provides important insights into the development of immune organs and the anti-aging effects of resveratrol in short-lived fish.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Diana Martin, Pedro Perdiguero, Esther Morel, Irene Soleto, J. German Herranz-Jusdado, Luis A. Ramon, Beatriz Abos, Tiehui Wang, Patricia Diaz-Rosales, Carolina Tafalla
Summary: CD38 has diverse expressions in different species, with high levels in mouse B cell subsets and transient expression on early lymphocyte precursors in humans while consistently expressed on terminally differentiated plasma cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xianliang Dai, Jian Zhao, Li Hua, Hui Chen, Chun Liang
Summary: Thymus transplantation can improve thymus function in hypertensive mice, leading to reduced blood pressure and improved heart function and structure.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Naveen Sharma, Eun-Joo Shin, Duc Toan Pham, Garima Sharma, Duy-Khanh Dang, Chu Xuan Duong, Sang Won Kang, Seung-Yeol Nah, Choon-Gon Jang, Xin Gen Lei, Toshitaka Nabeshima, Guoying Bing, Ji Hoon Jeong, Hyoung-Chun Kim
Summary: Selenium-dependent glutathione peroxidase GPx-1 may play a protective role against methamphetamine-induced dopaminergic toxicity, and overexpression of GPx-1 can significantly mitigate dopaminergic toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Psychiatry
Nan Chen, Haixia Liu, Jing Yao, Song Chen, Meihong Xiu, Fengchun Wu, Xiangyang Zhang
Summary: This study found that smoking had a greater improvement in negative symptoms in drug-naive first-episode schizophrenia patients after medication treatment. The study also found that there was a difference in antioxidant enzyme activity changes and symptom improvement, which was unrelated to smoking for smokers and related to nonsmokers.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Manpreet K. Semwal, Allison K. Hester, Yangming Xiao, Chioma Udeaja, Sergio Cepeda, John S. Verschelde, Nicholas Jones, Sarah A. Wedemeyer, Simon Emtage, Kymberly Wimberly, Ann V. Griffith
Summary: This study reveals that constitutive autophagy in TSCs is regulated by low expression of catalase, which affects central T cell tolerance and may be associated with the development of autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Cell Biology
Paulina Strzyz
Summary: Research shows that the stiffness of the extracellular matrix can regulate microtubule posttranslational modification through glutamylation, thereby influencing microtubule dynamics and cell invasiveness.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jacob D. R. McMillan, Kai N. Sands, Gary S. Cooney, Benjamin S. Gelfand, Thomas G. Back
Summary: Unexpected dimeric macrocycles with potent GPx-like activity were obtained during the preparation of spirodithiaselenuranes as GPx mimetics. The high catalytic activity of these products could be attributed to the transannular effects during selenide to selenoxide oxidation. Autocatalysis in the formation of intermediate selenoxide from the oxidation of the corresponding selenide was also observed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Tian-ying Xu, Peng Wang, Jia-sheng Tian, Sheng-li Qing, Shu-na Wang, Ya-hui Huang, Jin-yi Xu, Ding-feng Su, Jian-guo Liu, Chao-yu Miao
Summary: MT-1207 is a novel single-molecule multitarget agent for hypertension treatment that reduces blood pressure and organ damage, and delays stroke occurrence and death. It acts on multiple molecular targets and shows promising results in animal models.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Medicine, General & Internal
Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Philippe Saas, Cecile Courivaud, Thomas Crepin
Summary: ESRD patients exhibit clinical features of premature ageing such as frailty, cardiovascular disease, and muscle wasting, with immune system aging and chronic inflammation also being key factors. Preventing or reversing immune senescence/inflammation is a major goal to improve clinical outcomes for ESRD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Biophysics
Yuxiang Zhang, Wei He, Lei Yang, Liang Xuan, Jiamin Wu, Yucheng He, Yi Guo, Zheng Xu
Summary: This study proposes a spiral-out sequence for brain imaging using a portable 50-mT MRI system to address the problems of noise and blurring cancelation in ultralow-field magnetic resonance imaging (ULF-MRI). The proposed method provides higher SNR efficiency and noise suppression rate compared to its Cartesian counterparts, with an improvement in temporal SNR measured via experiments.
NMR IN BIOMEDICINE
(2023)
Review
Immunology
Pratibha Bhalla, Dong-Ming Su, Nicolai S. C. van Oers
Summary: The thymus, a primary lymphoid organ, plays a crucial role in producing T cells of the immune system. It can be damaged under certain types of systemic stresses and undergoes functional decline during aging. The microenvironment of the thymus, established through interactions between various cell types, influences thymus functions. Understanding the contributions of different stromal cell types in the thymus can inform strategies for restoring thymus functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chang Chu, Denis Delic, Jana Alber, Martina Feger, Yingquan Xiong, Ting Luo, Ahmed A. Hasan, Shufei Zeng, Mohamed M. S. Gaballa, Xin Chen, Lianghong Yin, Thomas Klein, Saban Elitok, Bernhard K. Kraemer, Michael Foeller, Berthold Hocher
Summary: This study using a rat AKI model confirmed the safety data from the EMPA-REG OUTCOME trial, indicating that empagliflozin may reduce AKI risk and have beneficial regulation of inflammation. These findings provide valuable insights for conducting clinical studies with AKI risk as the primary endpoint.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Virology
Ruhan Sun, Qin Wang, Zhenyu Huang, Mengting Zhan, Zhangchun Zhao, Bingchao Wang, Mengge Guo, Le Yuan, Zechao Shi, Gang Ouyang, Wei Ji
Summary: This study compares the immune response mechanisms of the head kidney and trunk kidney in fish against viral infection, and finds that despite functional differentiation, the trunk kidney still has a strong immune response.
