期刊
CHEMOSPHERE
卷 242, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.125138
关键词
Pesticide; Autophagy; Molecular mechanism; LC3B; Toxicity
资金
- National Key R&D Program of China [2017YFD0200503]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT17R97]
- Cultivation Fund of Zhejiang University of Technology for Excellent Doctoral Dissertation
Pesticides have become an essential tool for pest kill, weed control and microbiome inhibition for both agricultural and domestic use. However, with the massive use, pesticides can exist in soil, air and water, and sometimes even accumulate in the human or other mammals through food chains. Lots of researches have proven that pesticides possess toxicity to mammals on endocrine, neural and immune systems. Autophagy, as a conservative intracellular process, which is activated by stress-related signals, plays a pivotal role, either angle or demon, in regulation of cell fate and function. Recent evidences in researches elucidated a strong link between the autophagy and the toxicity of pesticides. In this review, we summarized the previous researches which focus on the autophagy regulation in the pesticides-induced toxicity, and hope that this work can help us to discover a potential strategy for the treatment of the disease caused by pesticides. (C) 2019 Elsevier Ltd. All rights reserved.
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