Article
Biochemistry & Molecular Biology
Yingya Zhao, Marina S. Nogueira, Ginger L. Milne, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Gong Yang
Summary: The study found that miRNAs associated with F2-IsoP-M are enriched for various lipid peroxidation-related processes, and some miRNAs exhibited functional interactions with mRNAs involved in the regulation of beta-oxidation.
Article
Nutrition & Dietetics
Ziling Mao, Roberd M. Bostick
Summary: The study found that individuals who were obese and had higher intake of carotenes, vitamin C, vitamin E, and other nutrients had lower plasma F-2-isoprostanes concentrations. A weighted oxidative balance score incorporating both dietary and lifestyle factors was significantly associated with lower F-2-isoprostanes concentrations.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Karen Savage, Lee Gogarty, Ana Lea, Saurenne Deleuil, Karen Nolidin, Kevin Croft, Con Stough
Summary: The increasing proportion of older citizens in society calls for a better understanding of the biological basis of mood as people age. This study examines the relationship between oxidative stress biomarkers and mood symptoms in healthy older adults. The findings suggest that elevated oxidative stress markers contribute to depressed mood and reduced general health in this population.
Review
Cell Biology
Kira Trares, Li-Ju Chen, Ben Schoettker
Summary: The association between F2-isoprostanes and Alzheimer's disease (AD) was systematically reviewed in this study. The results showed that F2-isoprostane levels were elevated in AD patients, especially in tissue samples of the frontal lobe and cerebrospinal fluid. However, due to methodological limitations and conflicting results from longitudinal studies, further research is needed to confirm this association.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Giulia Squillacioti, Fulvia Guglieri, Nicoletta Colombi, Federica Ghelli, Paola Berchialla, Paolo Gardois, Roberto Bono
Summary: This study aimed to systematically summarize the evidence on exercise-induced oxidative stress measured in urine and/or saliva, and found that the level of oxidative stress varied in response to different types and intensities of physical activity.
Article
Environmental Sciences
Lorena Franco-Martinez, Irene Brandts, Felipe Reyes-Lopez, Lluis Tort, Asta Tvarijonaviciute, Mariana Teles
Summary: Skin mucus is a non-lethal and low-invasive matrix that can be used to assess fish welfare and reflect changes in fish health status. This study found that skin mucus shows similar biochemical changes as plasma in response to stress, confirming its usefulness as a complementary matrix for stress assessment in fish. However, there were no statistically significant differences between skin mucus and plasma in some parameters, indicating that skin mucus cannot completely replace the use of plasma. Principal component analysis of skin mucus revealed a clear separation between the experimental groups.
Article
Veterinary Sciences
Mathilde Porato, Stephanie Noel, Joel Pincemail, Adelin Albert, Jean-Paul Cheramy-Bien, Caroline Le Goff, Annick Hamaide
Summary: This study evaluated the concentrations of nine oxidative stress biomarkers in 14 healthy Beagle dogs, proposing provisional physiological ranges for canine oxidative stress. Sex-related differences were found in zinc, copper/zinc ratio, and plasma isoprostanes. These provisional reference values are of importance for future studies on oxidative stress in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Fisheries
Neeraj Kumar, Nitish Kumar Chandan, Sanjay Kumar Gupta, Shashi Bhushan, Pooja Bapurao Patole
Summary: Arsenic pollution and climate change pose threats to the aquatic environment. Supplementation of EPA + DHA mixture can enhance growth performance, oxidative status, and immune response of fish while reducing bacterial infections.
Article
Nutrition & Dietetics
Jeffrey A. Rothschild, Andrew E. Kilding, Sophie C. Broome, Tom Stewart, John B. Cronin, Daniel J. Plews
Summary: This study found that exercising in the overnight-fasted state increased fat oxidation during submaximal exercise, while exercise following a carbohydrate-rich breakfast reduced fat oxidation. Pre-exercise protein ingestion allowed similarly high levels of fat oxidation, and there were no differences in perceived exertion, hunger, or performance. Additionally, pre-exercise nutrition ingestion did not influence exercise-induced oxidative stress.
Article
Public, Environmental & Occupational Health
Amir S. Heravi, Erin D. Michos, Di Zhao, Bharath Ambale-Venkatesh, Henrique Doria De Vasconcellos, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, Colin Wu, Cora E. Lewis, James M. Shikany, Stephen Sidney, Eliseo Guallar, Chiadi E. Ndumele, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Dhananjay Vaidya, Wendy S. Post
Summary: Postmenopausal women have higher oxidative stress levels, which may contribute to greater cardiovascular disease risk.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Amr Ghit, Hany El Deeb
Summary: Parkinson's disease (PD) is a common degenerative disorder of the CNS that primarily affects the human locomotor system. This study aimed to evaluate changes in blood-based biomarkers in PD patients. The results showed an increase in cytokine levels and a positive correlation among them in PD patients. Additionally, an increase in alpha-synuclein protein levels and a decrease in miR-214 levels were observed. Furthermore, decreases in levels of miR-221, miR-141, UA, PON1, and ARE were also found. A mix of noninvasive biomarkers is required to accurately predict disease state and progression in PD.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Carrie J. Nobles, Pauline Mendola, Sunni L. Mumford, Robert M. Silver, Keewan Kim, Neil J. Perkins, Enrique F. Schisterman
Summary: This study evaluated the role of oxidative stress biomarkers, such as isoprostanes, during the preconception period and 4 weeks gestation. It found that higher preconception isoprostane levels were associated with lower fecundability, while higher isoprostane levels at 4 weeks gestation were associated with lower risk of pregnancy loss.
Article
Plant Sciences
Jimei Zhang, Chonghong Zhang, Li Miao, Zimin Meng, Ning Gu, Guifang Song
Summary: This study explored the potential advantages of stigmasterol in asthma and found that it has anti-inflammatory and antioxidative stress effects. The results showed that stigmasterol can inhibit inflammation infiltration and mucus hypersecretion, and decrease NK1-R expression, providing a theoretical basis and more possibilities for the treatment of asthma.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinyue Liang, Zsolt Csenki, Bence Ivanovics, Illes Bock, Balazs Csorbai, Jozsef Molnar, Erna Vasarhelyi, Jeffrey Griffitts, Arpad Ferincz, Bela Urbanyi, Andras Acs
Summary: This study reveals the subacute effects of the common pharmaceutical residue carbamazepine (CBZ) on common carp, indicating significant adverse effects of CBZ exposure at concentrations often found in surface waters, including liver tissue damage and oxidative stress.
Article
Nutrition & Dietetics
Yong-Moon Mark Park, Jenna Lilyquist, Thomas J. Van't Erve, Katie M. O'Brien, Hazel B. Nichols, Ginger L. Milne, Clarice R. Weinberg, Dale P. Sandler
Summary: Plasma carotenoids, as well as supplemental beta-carotene, were found to be associated with lower concentrations of 8-iso-PGF(2 alpha) metabolite. These associations may reflect antioxidant effects.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Engineering, Environmental
Qianqian Jin, Danyang Tao, Yichun Lu, Jiaji Sun, Chun Ho Lam, Guanyong Su, Yuhe He
Summary: A robust method was developed to determine 38 target liquid crystal monomers in landfill leachate. 23 and 20 LCMs were detected in samples collected from municipal landfills in Hong Kong and Shenzhen, respectively, suggesting that landfill leachate may be a potential sink of LCMs emitted from e-waste. Further research is needed to investigate the potential migration of LCMs from landfill leachate and their ecotoxicological risk in aquatic environments.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
Tristan A. Smythe, Guanyong Su, Ake Bergman, Robert J. Letcher
Summary: In the flame retardant industry, there has been a trend of using more highly brominated compounds as replacements for banned and regulated compounds. However, there is a lack of knowledge regarding the metabolism and transformation potential of these new compounds. Current research shows variations in experimental protocols and a lack of information on the fate and metabolic pathways of certain environmentally relevant flame retardants. More studies are needed to understand the bioaccumulation and fate of these compounds in exposed organisms.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Environmental
Huijun Su, Kefan Ren, Rongrong Li, Jianhua Li, Zhanqi Gao, Guanjiu Hu, Pingqing Fu, Guanyong Su
Summary: This study reviewed existing literature on liquid crystal monomers (LCMs) and established a database containing 1173 LCMs. The physicochemical properties of these LCMs were calculated, and a suspect screening strategy tailored for LCMs was successfully developed. This strategy has the potential to be applied to other environmental matrices.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Shuai Gong, Kefan Ren, Langjie Ye, Yirong Deng, Guanyong Su
Summary: Ninety-five soil samples were analyzed to identify different OPEs and OPE-like substances. A total of 26 OPEs or OPE-like substances were identified, with BPABDP being the most frequently detected. The study also discovered four novel OPE structures, one of which shared a similar backbone structure with a well-known OPE, TDTBPP. This research provides the most comprehensive suite of OPEs in soil samples reported so far.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Ruifeng Bi, Guanyong Su
Summary: An integrated screening strategy was applied to analyze OPEs in 107 foodstuffs collected from Nanjing City, China in 2020. The results showed that meat samples were the most severely contaminated. Additionally, suspect and non-target analysis identified other OPEs, providing important information for food safety assessment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yurong Bao, Ming Zhu, Guanyong Su
Summary: This study investigated the bioaccumulation, tissue-specific accumulation, and depuration properties of liquid crystal monomers (LCMs) in adult zebrafish. The study found that the accumulation potential of LCMs varied among different functional groups, and LCMs with the cyan group were more likely to accumulate in zebrafish. The study also suggested that the bioaccumulation potential of some LCMs in aquatic environments might be overestimated by theoretical estimation techniques.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Rongrong Li, Kefan Ren, Huijun Su, Yu Wei, Guanyong Su
Summary: Recent studies have found the widespread presence of liquid crystal monomers (LCMs) in various environments, but there is limited information about their contamination in soil. This study collected soil samples from different urban functional zones and found that LCMs are widely distributed in surface soil. The agricultural zone had the highest concentration of LCMs, followed by commercial, residential, industrial, and scenic zones. Correlations between different LCMs were also observed, suggesting similar commercial applications and sources.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Correction
Engineering, Environmental
Kainan Nian, Wenhui Yang, Xuesheng Zhang, Rui Zhang, Wenli Xiong, Doug Crump, Guanyong Su, Xiaowei Zhang, Mingbao Feng, Jiaqi Shi
Article
Chemistry, Analytical
Vida Moradi, Thor Halldorson, Ifeoluwa Idowu, Zhe Xia, Nipuni Vitharana, Chris Marvin, Philippe J. J. Thomas, Gregg T. T. Tomy
Summary: Seabirds are valuable bioindicators of environmental health, and we have developed a new method to extract polycyclic aromatic compounds (PACs) from seabird plasma and serum. The method involves automated microbead-beating homogenization and extraction, and has shown good accuracy and repeatability for extracting PACs from important biological matrices.
Article
Environmental Sciences
Yi Kong, Yong Wen, Guanyong Su, Ying Peng, Xinyi Cui
Summary: Increasing evidence suggests that liquid crystal monomers (LCMs) in liquid crystal displays can be released into the environment and detected in environmental matrices and human bodies. However, there is a lack of databases regarding their uptake and distribution in mammals. This study investigated the distribution and accumulation of four LCMs in mice tissues, revealing their preferential deposition in lipophilic tissues and the influence of physico-chemical properties on their distribution and accumulation. These findings have important implications for biomonitoring and risk assessment of LCMs.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Haoduo Zhao, Caixia Li, Mihir Yogesh Naik, Jia Wu, Angelysia Cardilla, Min Liu, Fanrong Zhao, Shane Allen Snyder, Yun Xia, Guanyong Su, Mingliang Fang
Summary: Liquid crystal monomers (LCMs) are commonly used in liquid crystal display (LCD) industries, but their environmental occurrences and toxic effects have not been thoroughly studied. This study used in silico simulation, in vitro assays, and omics integration analysis to comprehensively investigate the toxicity and mechanism of LCMs. The results showed that certain LCMs significantly antagonized peroxisome proliferator-activated receptor gamma (PPARγ), leading to dysregulation of metabolome and transcriptome in HK2 cells. Dysregulation of fatty acid beta-oxidation, mediated through multiple pathways, and the activation of AMPK and ligand-dependent PPARγ antagonism were identified to play important roles. This study provides valuable insights for future chemical risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Weigao Zhang, Jiapeng Jie, Qian Xu, Rong Wei, Xin Liao, Danyang Zhang, Yayun Zhang, Jianfa Zhang, Guanyong Su, Yuxin Chen, Dan Weng
Summary: The incidence of obesity and non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly worldwide. Environmental factors such as plastic usage and chemical exposure have been suggested to be important contributors to the obesity epidemic. Acetyl tributyl citrate (ATBC), a commonly used non-phthalate plasticizer, has a high leakage rate from plastics, leading to increased exposure risk. This study aimed to evaluate the safety of subchronic exposure to environmentally-relevant concentrations of ATBC. Results showed that ATBC exposure led to weight gain, increased body fat content, larger adipocytes, and liver steatosis in mice. In vitro experiments also demonstrated increased intracellular lipid accumulation with ATBC treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Weikun Meng, Hao Sun, Guanyong Su
Summary: Plastic packaging contains residues from manufacturing substances and non-intentionally added substances (NIAS), such as impurities and degradation products. The study found that there are over 10,259 chemicals related to plastic packaging materials, and it discussed their structure, analysis methods, migration characteristics, and potential hazards.
Article
Environmental Sciences
Ruifeng Bi, Weikun Meng, Guanyong Su
Summary: An integrated screening method was optimized using UHPLC-HRMS to investigate the migration of OPEs from plastic food packaging. A total of 42 OPEs were identified, including seven new ones, in 106 samples collected in Nanjing, China. The study also revealed the oxidation products of AO626 in plastics, suggesting the importance of the oxidation of OPAs as an indirect source of OPEs. Migration of OPEs was observed in four simulated foods, with diverse OPEs detected at elevated concentrations in isooctane.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Vida Moradi, Thor Halldorson, Zhe Xia, Nipuni Vitharana, Chris Marvin, Philippe J. Thomas, Manon Sorais, Glenn T. Crossin, Gregg Tomy
Summary: Bird feathers are increasingly used as a non-invasive biomonitoring tool for environmental monitoring. A validated method for measuring polycyclic aromatic compounds (PACs) in bird feathers using pressurized fluid extraction and gas chromatography-tandem mass spectrometry is presented. The method provides accurate and efficient extraction and quantitation of PACs, eliminating the need for time-consuming acid treatment.
