Article
Environmental Sciences
Dongjie Wang, Xinyi Leng, Yao Tian, Jiangdong Liu, Jixing Zou, Shaolin Xie
Summary: Koumine, a common alkaloid found in Gelsemium elegans, has various pharmacological effects such as anti-tumor and anti-inflammatory properties. However, its high toxicity and unclear mechanism of action have limited its medicinal use. This study investigated the toxic effects of koumine on zebrafish embryos and larvae, and found that it affected their development and behavior by influencing the ACh content and AChE activity. The safe concentration of koumine for zebrafish was found to be less than 25 mg/L.
Article
Environmental Sciences
Yuanzhao Wu, Jiawen Wang, Yumei Xia, Kaiqin Tang, Jincheng Xu, Anli Wang, Shundi Hu, Luhong Wen, Binjie Wang, Weixuan Yao, Jiye Wang
Summary: This study demonstrated the developmental and neurotoxic effects of Isofenphos-methyl (IFP) on zebrafish embryos. IFP exposure resulted in abnormal heart development, uninflated swim bladder, and behavioral defects. Furthermore, IFP exposure activated oxidative stress and reduced acetylcholinesterase (AChE) content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yanhong Li, Bo Ren, Tingting Zhao, Haiyue Chen, Yuexing Zhao, Hanlin Liang, Hongwu Liang
Summary: This study investigated the enantioselective toxic effects of chiral pesticide mefentrifluconazole (MFZ) on zebrafish embryos and larvae. The results showed that different enantiomers of MFZ had different effects on the heart and neural development of the fish, accompanied by changes in gene expression.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Chao Xu, Tianyang Li, Chenjian Hu, Hangqin Guo, Jing Ye, Ling Li, Weiping Liu, Lili Niu
Summary: The study found that uranium can bioaccumulate in zebrafish larvae, resulting in significant developmental toxicities and changes in locomotor activities. Uranium exposure also affects thyroid hormone levels and related gene expression, highlighting the potential toxicities and thyroid disruption of uranium on zebrafish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Binjie Wang, Anli Wang, Chengrui Xu, Zan Tong, Yijing Wang, Xiaocong Zhuo, Lixiang Fu, Weixuan Yao, Jiye Wang, Yuanzhao Wu
Summary: Chlorprenaline hydrochloride (CLOR) is a β-adrenergic agonist that may be illegally used as a livestock feed additive and has adverse impacts on the environment. This study exposed zebrafish embryos to CLOR to investigate its developmental and neurotoxic effects. The results showed that CLOR exposure caused developmental toxicity and neurotoxicity in zebrafish embryos, including morphological changes, increased heart rate, altered locomotive behavior, and activation of oxidative stress.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafal Kretowski, Agata Jablonska-Trypuc, Marzanna Cechowska-Pasko
Summary: This study evaluated the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. The results showed that 5-15 nm SiNPs induced dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cells, and also induced apoptosis through decreasing mitochondrial membrane potential and increasing the activity of caspase-9 and caspase-3. Additionally, these nanoparticles caused an increase in selected oxidative stress parameters in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Garam An, Taeyeon Hong, Hahyun Park, Whasun Lim, Gwonhwa Song
Summary: In this study, the developmental toxicity of the carbamate insecticide oxamyl on zebrafish larvae was examined. Oxamyl was found to have adverse effects on the development of the neuron, notochord, and vascular system. Furthermore, it was found to impact the mitochondrial electron transport chain and the PI3K/Akt and p38 Mapk signaling pathways in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Yongmei Zhao, Qiongxia Yang, Dong Liu, Tianqing Liu, Lingyan Xing
Summary: Nanoparticles are widely used in industry and personal care, and their potential neurotoxicity has raised concerns. Zebrafish, as a model organism, provides valuable insights into the neurotoxic effects of nanoparticles and can help predict their impact on other species and humans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Liwang Xu, Xiaole Yang, Ying He, Qinglian Hu, Zhengwei Fu
Summary: In this study, the combined effects of tetracycline (TC) and titanium dioxide nanoparticles (TiO2 NPs) on the neurodevelopment of zebrafish larvae were investigated. The co-exposure of TC and TiO2 NPs resulted in increased embryonic malformation rates, abnormal nervous system development, and altered locomotor behavior in zebrafish embryos. Pathway enrichment analyses revealed significant effects on lipid metabolism and PPAR signaling pathway. Furthermore, the gene expression related to neural development was altered and the expression levels of neurotransmitters like 5-hydroxytryptamine, dopamine, acetylcholinesterase, and γ-aminobutyric acid were up-regulated. These findings demonstrated the potential neurotoxicity of TC and TiO2 NPs in zebrafish embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yen-Ling Lee, Yung-Sheng Shih, Zi-Yu Chen, Fong-Yu Cheng, Jing-Yu Lu, Yuan-Hua Wu, Ying-Jan Wang
Summary: This study investigated the effects of silver nanoparticles and zinc oxide nanoparticles on zebrafish embryos in aquatic environments. The research found that spiking these nanoparticles into natural water samples had a toxic effect on the embryos, with the level of toxicity influenced by complex components in the water. Additionally, zinc oxide nanoparticles caused a delay in embryo hatching. Measurement of reactive oxidative stress levels, apoptosis, and autophagy revealed the interaction and toxicity mechanisms of the nanoparticles with the embryos.
Article
Food Science & Technology
Rong Fan, Jin Chen, Xiaocheng Gao, Qinli Zhang
Summary: The neurodevelopmental toxicity of alumina nanoparticles on zebrafish larvae mainly depends on the size of the nanoparticles, and dissolved aluminum ions also contribute to the toxic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Engineering, Environmental
Francisco Carlos da Silva Junior, Thais Agues-Barbosa, Ana Carolina Luchiari, Silvia Regina Batistuzzo de Medeiros
Summary: The study demonstrates the genotoxic and neurotoxic effects of Retene on zebrafish, indicating the potential to induce DNA micronuclei formation and behavioral changes. The results suggest that alterations in oxidative stress and mRNA expression of neurotransmitter systems may contribute to these effects.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
Guiqing Zhou, Jianhui Liu, Xiangyang Li, Yujian Sang, Yue Zhang, Leqiang Gao, Ji Wang, Yang Yu, Wei Ge, Zhiwei Sun, Xianqing Zhou
Summary: The study found that SiNPs can induce reproductive toxicity by inhibiting the expression of miR-450 b-3p, which activates the mitochondrial apoptosis signaling pathways.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla
Summary: This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish larvae, finding that approximately half of the chemicals showed no gross developmental toxicity at the highest concentration tested. Some chemicals were toxic only at higher concentrations, while 11 chemicals caused behavioral effects, with four altering behavior in the absence of developmental toxicity.
Article
Agriculture, Multidisciplinary
Xiang Li, Gaopan Dong, Guangxi Han, Lupei Du, Minyong Li
Summary: Despite clinical and epidemiological data linking chronic overconsumption of artificial sweeteners (ASs) to adverse health effects, controversies remain over their potential adverse neural toxic effects. This study used adult zebrafish as an animal model to show that within the acceptable daily intake (ADI) range, aspartame (APM) altered the behavioral profiles of zebrafish and disrupted neurotransmitter homeostasis in the brain. The standardized experimental paradigms established here provide a predictive reference for further exploration of the molecular mechanisms of phenotypic changes induced by ASs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shanshan Zhang, Yan Gao, Qiuxia He, Yun Zhang, Liwen Han, Meng Jin, Tong Liu, Kechun Liu, Chen Sun
Summary: Gentamicin is a commonly used drug for severe Gram-negative bacterial infections, but its use is limited due to its ototoxic effects. In this study, a novel active peptide from Neptunea arthritica cumingii was found to have otoprotective effects without significant embryotoxicity. The combined application of gentamicin and this novel active peptide helped sensory-hair cells protect themselves from lethal ROS accumulation, reducing the expression of genes associated with apoptosis in response to gentamicin-induced ROS accumulation.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Xiang Li, Jiao Dang, Yan Li, Lizhen Wang, Ning Li, Kechun Liu, Meng Jin
Summary: Larval zebrafish is an ideal model for FET testing and neurotoxicity research, with locomotion profiles monitored by behavioral tracking systems. Silica nanoparticles showed significant toxicity on larval zebrafish at environmentally relevant concentrations, inducing neurotoxic effects that can be further evaluated through behavioral responses.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Xueliang Shang, Congying You, Xiang Li, Lu Yuan, Meng Jin, Xiujun Zhang
Summary: Aristolochic acid I (AAI) exposure in mice led to increased anxiety levels and behavioral despair, as well as higher error rates in cognitive tasks. Molecular docking studies indicated potential interaction with the 5-HT2 serotonin receptor. Mechanism investigation revealed AAI-triggered inflammation in the hippocampus, affecting cognition in C57BL/6 mice.
Article
Nanoscience & Nanotechnology
Xiang Li, Peng Zhang, Yunqiu Hua, Fucai Cui, Xue Sun, Lin Liu, Yanxiao Bi, Zhongjie Yue, Guodong Zhang, Xutang Tao
Summary: In this study, high-quality inch-size Cs3Bi2Br9 (CBB) single crystals were grown using the Bridgman method. The crystal quality was improved by eliminating inclusions and reducing trap-state density, leading to enhanced resistivity and mobility lifetime product. The Au/CBB/Au single crystal device exhibited high sensitivity and ultralow detection limit for hard X-ray detection. The CBB detector demonstrated high work stability and low dark current drift under a high electric field, making it a promising tool for X-ray medical imaging and diagnostics.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Xuezhen Li, Daili Gao, Yam Nath Paudel, Xia Li, Mingzhu Zheng, Guangpeng Liu, Yanrui Ma, Le Chu, Fatao He, Meng Jin
Summary: This study found that Sanghuangprous vaninii mycelium extracts (SvMEs) have anti-Parkinson's disease effects, reversing the loss of dopaminergic neurons and neurovascular reduction, and relieving locomotor impairments in zebrafish. Furthermore, SvMEs exhibited significant antioxidant activity. The results indicate that SvMEs may alleviate PD-like symptoms by alleviating oxidant stress and accelerating alpha-synuclein degradation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Peng Zhang, Yunqiu Hua, Yadong Xu, Qihao Sun, Xiang Li, Fucai Cui, Lin Liu, Yanxiao Bi, Guodong Zhang, Xutang Tao
Summary: In this study, the electrical properties and X-ray detection performances of CsPbBr3-nIn single crystals were improved by doping iodine atoms. The resistivity of CsPbBr3-nIn single crystals increased, decreasing the detection limit and restraining the leak current. The CsPbBr3-nIn single crystals showed stable dark currents, achieving record sensitivity and low detection limit for X-ray detection.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Fucai Cui, Peng Zhang, Longzhen Zhang, Yunqiu Hua, Xue Sun, Xiang Li, Guodong Zhang, Xutang Tao
Summary: This study presents a liquid-phase epitaxial method to construct perovskite single-crystal heterojunctions, effectively suppressing ion migration in three-dimensional halide perovskites and enabling the creation of high-performance X-ray detectors. The constructed MAPbBr3/CsPbBr3 heterojunction exhibits a record-high sensitivity and a low detection limit, while suppressing dark current drift even in a high reverse electric field.
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Medicinal
Xiang Li, Minyong Li
Summary: Developing effective drug screening methods is crucial for antitumor drug research. Patient-derived xenograft (PDX) tumor animal models and zebrafish as a screening model organism enable accurate and rapid discovery of lead compounds in the preclinical stage, while elucidating tumor pathogenesis.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Genetics & Heredity
Xiang Li, Zihan Dai, Jincheng Liu, Zhenqian Sun, Na Li, Guangjun Jiao, Hongxin Cao
Summary: This study comprehensively analyzed the differential expression and genetic alterations of FDX1 in tumors and explored its role in regulating cell activity, biological processes, and drug sensitivity. Experimental results confirmed the antitumor effects of FDX1 through copper-induced cell death. The study deepened our understanding of FDX1 effects and confirmed its role as a biomarker for copper cell death.
FRONTIERS IN GENETICS
(2022)
Review
Food Science & Technology
Ruidie Shi, Daili Gao, Rostyslav Stoika, Kechun Liu, Attila Sik, Meng Jin
Summary: This review aims to overview the potential neuroprotective roles of polyphenols in most common neurodegenerative disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Nazar Manko, Marina Starykovych, Nataliya Mitina, Kateryna Volianiuk, Lizhen Wang, Meng Jin, Kechun Liu, Rostyslav Panchuk, Olga Klyuchivska, Alexander Zaichenko, Yuriy Kit, Rostyslav Stoika
Summary: A previously unknown Ser-Pro-Cys (SPC) tripeptide was detected in the blood serum of multiple sclerosis patients. The SPC was immobilized on a biocompatible PEGylated comb-like polymer, which unexpectedly exhibited anticancer activity towards human tumor cells in vitro. The conjugate showed pro-apoptotic action without cytotoxic effects on normal lymphocytes. The macromolecular complex can potentially serve as a nanoplatform for drug delivery in anticancer chemotherapy.
Article
Neurosciences
Meng Jin, Ruidie Shi, Daili Gao, Baokun Wang, Ning Li, Xia Li, Attila Sik, Kechun Liu, Xiujun Zhang
Summary: This study aims to identify a promising biomarker for Parkinson's disease (PD) using reverse phase protein array (RPPA) technology and in vivo verification. The biomarker discovered can facilitate early intervention in PD, leading to improved treatment effectiveness and reduced disease morbidity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Xin Gao, Baoyue Zhang, Yuanteng Zheng, Xuchang Liu, Panchuk Rostyslav, Nataliya Finiuk, Attila Sik, Rostyslav Stoika, Kechun Liu, Meng Jin
Summary: Parkinson's disease (PD) is a disease characterized by motor and non-motor symptoms. Current therapies are not effective, so there is a need for further research on preventative or disease-modifying treatment agents. Chlorogenic acid (CGA), a compound extracted from natural sources, has shown potential as an antioxidant and neuroprotector. This study found that CGA can relieve PD symptoms and promote autophagy in neuronal cells, making it a potential candidate for treating PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feng-hua Xu, Yue-zi Qiu, Yun Zhang, Fang-hao Yang, Min-min Ji, Ke-chun Liu, Meng Jin, Shan-shan Zhang, Bing Li
Summary: Previous studies have shown that peptides isolated from C-phycocyanin (C-PC) possess various functions including antioxidant and anticancer activities. However, there is little research on C-PC peptides applied for the neuroprotective effect against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) model. In this study, twelve novel peptides from C-PC were isolated, purified and identified, and the anti-PD effect of the synthesized peptides was evaluated in a zebrafish PD model. Three of these peptides (MAAAHR, MPQPPAK, and MTAAAR) significantly reversed the loss of dopamine neurons and cerebral vessels, and reduced the locomotor impairment in PD zebrafish. Furthermore, these peptides also exhibited antioxidant and anti-apoptotic effects in the zebrafish model. The potential molecular mechanism of peptides' anti-PD effects were further elucidated, showing their ability to modulate genes associated with oxidative stress, autophagy, and apoptosis signaling pathways.
Article
Chemistry, Multidisciplinary
Miaohui Yu, Tingting Fu, Wenzhai Li, Yan Zhang, Huayan Wen, Min Zheng, Moran Shi, Caiyun Liu, Meng Jin, Kechun Liu, Lei Cai, Baocun Zhu, Wenlong Sheng
Summary: In this study, a novel Hg2+ fluorescent probe TD-Hg was constructed, which can respond to Hg2+ in a very short time and has a high sensitivity for detecting Hg2+ in environmental water samples. Moreover, the probe has good biocompatibility and the ability to monitor Hg2+ in biological systems.
NEW JOURNAL OF CHEMISTRY
(2023)
