Article
Polymer Science
Marcin Mackiewicz, Serife Dagdelen, Kamil Marcisz, Ewelina Waleka-Bargiel, Zbigniew Stojek, Marcin Karbarz
Summary: This paper presents the synthesis of a pH-sensitive and degradable microgel as a high-capacity doxorubicin-drug carrier, which can release the drug under specific conditions and show higher cytotoxicity against cancer cells.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Multidisciplinary Sciences
Kamonchanok Thananukul, Chariya Kaewsaneha, Pakorn Opaprakasit, Nadia Zine, Abdelhamid Elaissari
Summary: This study focuses on the design and development of porous biodegradable micro/nanoparticles embedded with thermoresponsive gatekeepers for controlled drug delivery. The gatekeepers, made of crosslinked PNIPAM, demonstrate high loading efficiency and precise release of the active compound. The materials show a promising potential for controlled drug delivery systems with an accurate and easy triggering mechanism.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Clea Chesneau, Alpha Oumar Sow, Fadila Hamachi, Laurent Michely, Sena Hamadi, Remy Pires, Andre Pawlak, Sabrina Belbekhouche
Summary: Tailor-made micro- and nanocarriers, combining cyclodextrin and calcium carbonate, were developed for loading hydrophobic drugs. The particle size of the resulting cyclodextrin-CaCO3 particles can be controlled by adjusting the concentration of PVSA or gly and the mixing time. These particles show high stability and biocompatibility, and exhibit selective release in acidic media.
Article
Chemistry, Applied
Qiong Xiao, Zizhou Chen, Xiangji Xie, Yonghui Zhang, Jun Chen, Huifen Weng, Fuquan Chen, Anfeng Xiao
Summary: A novel agar-based Pickering emulsion stabilizer was developed through hydrophobic modification and microgelation of agar. The modified agar microgels formed a dense network structure, providing an effective barrier for preventing droplet coalescence and Ostwald ripening.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan
Summary: The Am-PNCage is a novel protein nanocarrier with dual-targeting properties, allowing for effective drug loading and promoting drug penetration and accumulation in tumors in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Saweta Garg, Marloes Peeters, Rakesh Kumar Mahajan, Pankaj Singla
Summary: In this study, mixed micelles of normal pluronic and reverse pluronic were found to have higher solubilization capacity for the hydrophobic drug silymarin (SLY) compared to pure pluronic micelles. Among the mixed micelles, the P84:10R5 (4:1% w/v) formulation showed maximum solubility and drug loading efficiency. The mixed micellar formulation exhibited sustained release drug behavior and enhanced anti-oxidative activity compared to SLY alone.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Sebastian Stock, Franziska Jakob, Susanne Roehl, Kevin Graeff, Matthias Kuehnhammer, Nicole Hondow, Stuart Micklethwaite, Matthias Kraume, Regine von Klitzing
Summary: The simultaneous stabilization of water droplets in a highly non-polar oil phase using temperature responsive, soft and hydrophilic PNIPAM microgel particles and solid and hydrophobic silica nanospheres allows for the formation of stable water-in-oil emulsions with a larger internal interface. This synergistic effect enables the particles to protect the droplets from coalescence and accelerate the emulsions sedimentation speed, while still maintaining the ability to redisperse the droplets by gentle shaking. The study provides a model to explain the phenomena observed in terms of droplet size measurements and cryo-SEM studies.
Article
Nanoscience & Nanotechnology
Teresa Alejo, Laura Uson, Guillermo Landa, Martin Prieto, Cristina Yus Argon, Sara Garcia-Salinas, Ricardo de Miguel, Ana Rodriguez-Largo, Silvia Irusta, Victor Sebastian, Gracia Mendoza, Manuel Arruebo
Summary: This study reports the development of thermoresponsive nanogels loaded with bupivacaine nanocrystals for prolonged peripheral nerve pain relief. The nanogels showed high drug loadings and fast drug dissolution kinetics, allowing for an extended duration of sciatic nerve block in in vivo tests. The encapsulation of bupivacaine nanocrystals provided a prolonged regional anesthesia with reduced toxicity, showing potential for the management of chronic pain.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Quanying Bao, Suraj Fanse, Xiaoyu (James) Lu, Diane J. Burgess
Summary: This study investigates the impact of drug loading on the release of Levonorgestrel intrauterine systems (LNG-IUSs) by preparing drug reservoirs with different drug loading and conducting release testing under accelerated conditions. The results show that the release rate of LNG-IUSs is inversely proportional to the drug loading. Low drug loading leads to incomplete drug release or even no drug release at all. Accelerated release testing methods are found to be representative of real-time release profiles, providing confidence in extending the duration of usage for these products as long as the device remains intact and the release rate is within the therapeutic window.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Shuai Zhang, Chao Liu, Yilin Song, Jiuheng Ruan, Peng Quan, Liang Fang
Summary: This study developed a new pressure sensitive adhesive modified with hydroxyphenyl (HP-PSA), which showed a reversible and strong interaction with certain model drugs. This interaction significantly increased drug-loading and controlled drug release rate without altering release properties. Patches based on HP-PSA achieved sustained plasma drug concentration, indicating its potential for long-acting drug delivery. The construction of doubly ionic H-bond in HP-PSA provides inspiration for drug delivery in non-polar environments.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Zhimin Li, Xianjing Feng, Shixing Luo, Yanfeng Ding, Zhi Zhang, Yifeng Shang, Doudou Lei, Jinhong Cai, Jinmin Zhao, Li Zheng, Ming Gao
Summary: A study on modified cross-linked dextran (Sephadex, S0) found that the introduction of a longer hydrophobic chain, especially an aromatic chain, significantly improved the hydrophobicity of S0, increased the loading efficiency of ibuprofen, and further led to significantly improved therapeutic effects for osteoarthritis.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ghazal Rastegar, Mohammad Musa Salman, Shashank R. Sirsi
Summary: The use of drug-loaded microbubbles for targeted drug delivery, particularly in cancer treatment, has been extensively studied. However, the loading capacity of microbubbles has been limited. In this study, a novel approach was introduced to load doxorubicin in crystallized form in the core of polymeric microcapsules, creating remotely loaded microbubbles (RLMBs). These RLMBs exhibited a significantly higher drug payload compared to physically loaded microcapsules. Furthermore, the drug release of RLMBs was investigated under ultrasound field, showing a remarkable capability for on-demand drug release.
Article
Chemistry, Physical
Wei Wu, Jianxi Liu, Xiao Lin, Zhengze He, Hui Zhang, Le Ji, Peiwei Gong, Feng Zhou, Weimin Liu
Summary: This paper demonstrates the hybridization of copolymer microgel with drug-loaded metal-organic frameworks nanoparticles for synergistic treatment of osteoarthritis. The hybrid microgel shows excellent aqueous lubricating performance and anti-inflammatory effect. The study also presents the thermo-responsive behavior and drug release properties of the hybrid microgel, which has potential for advanced colloids modulation and biomedical application.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biophysics
Yutong Wang, Huaning Li, Lingchong Wang, Jiawei Han, Yujie Yang, Tingming Fu, Hongzhi Qiao, Zengwu Wang, Junsong Li
Summary: The study utilized nanocrystals technology to fabricate silybin nanocrystals, which were then loaded into mucoadhesive microspheres to enhance retention time in the gastrointestinal tract and improve drug bioavailability. The developed delivery system showed high encapsulation efficiency and drug loading capacity, with mucoadhesive microspheres demonstrating excellent retention properties in ex vivo tests. Additionally, the drug release percentage and oral bioavailability were significantly improved compared to unprocessed silybin, highlighting the potential of nanocrystals technology in enhancing drug delivery systems.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Suji Ryu, Seungyeop Park, Ha Yeon Lee, Hyungjun Lee, Cheong-Weon Cho, Jong-Suep Baek
Summary: This study developed microcapsules loaded with alginate-coated chitosan to increase the encapsulation efficiency of hydrophilic drugs while reducing initial burst release, providing controlled and sustained release. The encapsulation of nanoparticles in PLGA microcapsules demonstrated enhanced encapsulation efficiency of hydrophilic drugs, showing promising potential for sustained release with reduced initial burst release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Dana Al Sulaiman, Sarah J. Shapiro, Jose Gomez-Marquez, Patrick S. Doyle
Summary: This research demonstrates the ability to synergistically combine hydrogels and fibrous substrates into a portable biosensing platform using projection lithography, offering a versatile and multiplex detection method for multiple biomarkers, particularly suitable for early cancer detection.
Article
Chemistry, Multidisciplinary
Liang-Hsun Chen, Patrick S. Doyle
Summary: This study successfully developed a new thermogelling nanoemulsion and a thermal dripping method for efficient preparation of composite particles with a methylcellulose (MC) matrix embedded with precisely controlled API nanocrystals. By combining a fast-eroding MC matrix and fast-dissolving API nanocrystals, a fast and tunable release performance was achieved. The versatile thermal processing approach allows for the easy formulation of a wide variety of dosage forms, showing great promise for more efficient formulation of oral drug products with high quality and tunable fast release.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Beatrice W. Soh, Patrick S. Doyle
Summary: The research utilizes single-molecule experiments to show that the in-plane size of kinetoplasts increases with the degree of confinement. The kinetoplasts appear to unfold and take on more uniform circular shapes with an increase in extent of confinement.
Article
Polymer Science
Indresh Yadav, Dana Al Sulaiman, Beatrice W. Soh, Patrick S. Doyle
Summary: This study reports the polymer-and-salt-induced phase transition of 2D catenated DNA networks, called kinetoplasts, using single-molecule fluorescence microscopy. It is observed that kinetoplasts can undergo a reversible transition from the flat phase to the collapsed phase in the presence of NaCl as a function of the crowding agent poly(ethylene glycol). The nature of this phase transition is tunable through varying ionic strengths.
Article
Engineering, Biomedical
Dana Al Sulaiman, Nidhi Juthani, Patrick S. Doyle
Summary: This study demonstrates the development and application of a method for quantitative and multiplex detection of EV-miRNA, which avoids the bias and losses associated with standard RNA extraction techniques. The method offers a large dynamic range, ease of multiplexing, and shows utility in clinical applications based on liquid biopsy tests.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Meghali Bora, Myat Noe Hsu, Saif A. Khan, Patrick S. Doyle
Summary: In this study, a hydrogel-templated anti-solvent crystallization method is introduced for the fabrication of microparticles containing dispersed nanocrystals of poorly soluble API. The method allows for controllable drug loading and tailored dissolution profiles by altering the template particle size.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Devashish Gokhale, Ian Chen, Patrick S. Doyle
Summary: This study introduces a hydrogel-based polymeric absorbent with immobilized micelles for efficient removal of hydrophobic micropollutants from water. The absorbent, prepared by synthesizing surfactant micelles and incorporating them into hydrogels, showed faster adsorption rates compared to a commercially available activated carbon. Furthermore, a sustainable and facile method for regenerating the spent absorbent was demonstrated.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Physical
Liang-Hsun Chen, Patrick S. Doyle
Summary: The developed thermogelling nanoemulsions provide a new approach for the development of oral films, effectively improving the water solubility of drugs and increasing drug loading capacity. This new method can prevent irreversible nanoparticle aggregation, providing a more efficient and controllable solution for the preparation of oral films.
CHEMISTRY OF MATERIALS
(2022)
Article
Mechanics
Mary A. A. Joens, Patrick S. S. Doyle, Gareth H. H. McKinley, James W. W. Swan
Summary: This study investigates the motion of a small rotating spherical particle in a two-dimensional trajectory through a viscoelastic fluid using the Giesekus model. The study analyzes both steady-state and time-dependent flows, quantifying the relative unsteadiness and nonlinearity of the flows. The impact of changing dimensionless parameters on the flow characteristics is discussed.
Article
Chemistry, Medicinal
Purnima N. Manghnani, Luke Schenck, Saif A. Khan, Patrick S. Doyle
Summary: The commercialization of promising active pharmaceutical ingredients (APIs) is hindered by poor bioavailability and challenging physical properties. This study presents a method to improve API physical properties by performing reactive crystallization of an API salt in the presence of a hydrogel microparticle. The use of spherical template hydrogel microparticles leads to composites loaded with micronized crystals, enhancing API physical properties without affecting bioavailability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Lucas Attia, Liang-Hsun Chen, Patrick S. Doyle
Summary: A novel dual-responsive gelation process that combines thermo-responsive and ion-responsive gelations is introduced in this study. This process synthesizes core-shell hydrogel particles and encapsulates drug-laden nanoemulsions, allowing in situ crystallization of drug nanocrystals in the polymeric core and templating of a kinetically stable amorphous solid dispersion in the shell. The study demonstrates programmable drug release for various therapeutic applications and independent control over drug loading between the shell and the core. This flexible formulation approach offers biocompatible materials, facile synthesis, and precise drug release performance.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Physics, Multidisciplinary
Indresh Yadav, Dana Al Sulaiman, Patrick S. Doyle
Summary: The molecular topology of polymers has a significant impact on their physical properties. In this study, the effects of topology on the static and dynamic properties of a 2D network of DNA rings called a kinetoplast were investigated. By selectively cutting and removing rings from the network using restriction enzymes, the molecular topology was modified while maintaining the overall structural integrity. It was found that topology had minimal effects on the spatial extension of the network but significantly influenced its relaxation behavior.
PHYSICAL REVIEW RESEARCH
(2023)
Article
Chemistry, Physical
Sima Asadi, Arif Z. Nelson, Patrick S. Doyle
Summary: Non-spherical hydrogel particles with various shapes can be synthesized by leveraging the yield stress property of viscoplastic fluids. The shape-engineered alginate particles can be controlled by tuning the yield stress of the solution and the nozzle tip orientation.
Article
Chemistry, Physical
Devashish Gokhale, Ian Chen, Patrick S. Doyle
Summary: This study presents a novel coarse-grained molecular dynamics simulations framework for the rapid identification of surfactants for use in immobilized micelle systems. The results show that there are stronger interactions between micelles and small hydrophobic molecules in immobilized systems compared to unconstrained systems, which have important implications for the design of new micelle-based extraction and delivery processes.
Article
Biochemical Research Methods
Jae Jung Kim, Mehdi Jorfi, Rudolph E. Tanzi, Doo Yeon Kim, Patrick S. Doyle, Daniel Irimia
Summary: Brain spheroids are valuable in vitro models for accelerating research in various diseases, including Alzheimer's disease. However, challenges remain in studying the progression of AD and the propagation of pathogenic proteins in the brain spheroids model. To address this, researchers have designed a microfluidic system to connect different brain spheroids and promote the accumulation of pathogenic proteins within the spheroids.