期刊
CHEMICAL ENGINEERING JOURNAL
卷 378, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.122025
关键词
Gold bipyramids; Surface plasmon resonance; Photostability; CT imaging; Photothermal therapy
资金
- National Key R&D Program of China [2016YFE0129600]
- National Natural Science Foundation of China [21673150, 51802206]
- Natural Science Foundation of Jiangsu Province [BK20180846]
- Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC)
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Soochow University
- 111 Project
Monodisperse gold bipyramids (AuBPs) with controlled aspect ratio and tunable surface plasmon resonance (SPR) property have been synthesized using cetyltrimethylammonium bromide (CTAB) and sodium oleate (NaOL). The morphological yield of AuBPs is about 90% without any purification step. The presence of NaOL plays an important role in promoting the morphological yield of AuBPs by pre-reduce Au3+ to Au+. The obtained AuBPs exhibit strong absorbance in the near infrared region (NIR) that can be systematically tuned from 740 nm to 960 nm. After functionalized with polyethylene glycol (PEG), the as-prepared AuBPs have shown excellent photothermal stability and great biocompatibility, which could be used for high contrast computed tomography (CT) imaging and photothermal cancer therapy. This work provides not only a simple method for the synthesis of AuBPs with high morphological yield, but also a promising theranostic agent for cancer therapy.
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