Article
Biochemistry & Molecular Biology
Nagarajan Maharajan, Gwang-Won Cho
Summary: The study found that CQ may reduce senescence in hBM-MSCs and mouse heart tissues, and enhance AMPK/SIRT1 activation and autophagy in both models. CQ also lowered the gene expression of inflammation markers in D-Gal-induced aging mouse heart tissues.
Article
Immunology
Qi Liang, Rongjie Guo, Jia-Ruei Tsao, Yun He, Chenchen Wang, Jiaxuan Jiang, Di Zhang, Taige Chen, Tingting Yue, Kai Hu
Summary: This study investigated the therapeutic effects of salidroside, the main component of Rhodiola crenulata, in dry eye disease. The results showed that salidroside restored corneal epithelium damage, increased tear secretion, and reduced cornea inflammation. The activation of autophagy and antioxidant pathways played a crucial role in these therapeutic effects. Therefore, salidroside is a promising candidate for dry eye disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Kuan Liu, Zhiqi Liu, Zhuofan Liu, Zhuo Ma, Yu Deng, Wei Liu, Bin Xu
Summary: This study demonstrates that the nitrosation of PINK1 by manganese leads to dysregulation of mitophagy, resulting in nerve cell injury. These findings reveal the connection between nitrative stress and mitochondrial dysfunction in manganese-induced neurotoxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Cell Biology
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi
Summary: Ferroptosis, a newly discovered form of programmed cell death, is characterized by peroxidative damage to polyunsaturated-fatty-acid-containing phospholipids and is highly dependent on iron ions. It is closely associated with the pathogenesis of various diseases and is regulated by multiple signaling pathways, including the MAPK-AMPK pathway. This review summarizes the molecular mechanisms underlying the regulation of ferroptosis by the MAPK-AMPK pathway and discusses the potential therapeutic strategies targeting this pathway.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Xiao-Die Wang, Wei-Li Yu, Yun Sun
Summary: In this study, the role of the AMPK-SIRT1 pathway in acute pancreatitis (AP) was investigated. The results showed that AMPK and SIRT1 were down-regulated in AP, leading to impaired autophagy and increased inflammation. Activation of AMPK restored impaired autophagy and inhibited inflammation by up-regulating SIRT1.
Article
Cell Biology
Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Guo
Summary: The study revealed that up-regulation of SIRT1 induced by 17 beta-E2 promoted autophagy and inhibited apoptosis in osteoblasts through the AMPK-mTOR and FOXO3a pathways. This suggests that SIRT1 may be a valuable target for osteoporosis treatment, providing new insights into its role in protecting bone cells.
Article
Immunology
Xiao Liu, Bo Yang, Ya-Fang Tan, Jian-Guo Feng, Jing Jia, Cheng-Jie Yang, Ye Chen, Mao-Hua Wang, Jun Zhou
Summary: This study investigated the role of the AMPK-Sirt1-autophagy pathway in intestinal injury and found that propofol can reduce intestinal injury and improve the prognosis by activating this pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Review
Biochemistry & Molecular Biology
Begona Sanchez, Mario F. Munoz-Pinto, Mercedes Cano
Summary: Studying the process of ageing is crucial for ensuring optimal conditions in the final stages of life. Irisin, a myokine secreted during physical exercise, has gained interest for its potential role in the ageing process and its association with key anti-ageing pathways.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango, Koichi Kato
Summary: This study reveals the potential application value of docosahexaenoic acid (DHA) in diabetic neuropathy. The experimental results suggest that DHA can inhibit oxidative stress-induced cell death, attenuate excessive autophagy, and has the potential to protect Schwann cells from oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jain Siddhi, Bhoomika Sherkhane, Anil Kumar Kalavala, Vijay Arruri, Ravichandiran Velayutham, Ashutosh Kumar
Summary: This study assessed the protective effect of melatonin against diabetic renal injury and found that melatonin can improve renal function and mediate renal protection by activating the AMPK/SIRT1 axis, enhancing autophagy, and promoting mitochondrial health.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Nan Gao, Yang Yang, Siqi Liu, Chunyang Fang, Xiujing Dou, Licong Zhang, Anshan Shan
Summary: Tryptophan modulates metabolic pathways to maintain gut immune defense, reduce inflammation, and protect intestinal mucosal barrier and gut microbiota composition. These effects are mainly mediated through the regulation of the AMPK-SIRT1-autophagy pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bai Yu, Yanhua Zhao, Shichao Teng, Yongcheng Ni, Shunjuan Xu, Xiang Wu, Jing Zhang, Xiru Xu, Yuan Fang, Jun Shi, Biao Zhang
Summary: Atractylodin may be used as an anti-cachexia drug, with the underlying mechanism potentially involving the promotion of NPY expression through Sirt1/AMPK-regulated autophagy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tianwen Ma, Liangyu Lv, Yue Yu, Lina Jia, Xiaopeng Song, XinYu Xu, Ting Li, Xuanbo Sheng, Haoran Wang, Jiantao Zhang, Li Gao
Summary: Bilobalide can induce chondrocyte autophagy through activating the AMPK/SIRT1/mTOR signaling pathway, and it has been shown to have anti-inflammatory and anti-ECM degradation effects in both in vivo and in vitro experiments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pranjal Biswas, Puranjoy Kar, Sanjay Ghosh
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Article
Genetics & Heredity
Pranjal Biswas, Sanjay Ghosh
Article
Biochemistry & Molecular Biology
Sourav Kumar Patra, Prasanta Kumar Bag, Sanjay Ghosh
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Sampurna Datta, Subhamoy Chakraborty, Chiranjit Panja, Sanjay Ghosh
FREE RADICAL RESEARCH
(2018)
Article
Microbiology
Puranjoy Kar, Pranjal Biswas, Sourav Kumar Patra, Sanjay Ghosh
MICROBIOLOGICAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Chiranjit Panja, Sanjay Ghosh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Tuhin Subhra Sarkar, Pranjal Biswas, Subrata Kumar Ghosh, Sanjay Ghosh
Article
Biotechnology & Applied Microbiology
Achintya Mohan Goswami, Tuhin Subhra Sarkar, Sanjay Ghosh
Article
Biochemistry & Molecular Biology
Sourav Kumar Patra, Sourabh Samaddar, Nilanjan Sinha, Sanjay Ghosh
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Microbiology
Nilanjan Sinha, Sourav Kumar Patra, Tuhin Subhra Sarkar, Sanjay Ghosh
Summary: Macrophomina phaseolina, a necrotrophic fungal pathogen, can cause charcoal rot disease in various food crops. It can overcome reactive oxygen species-induced cellular damage by producing superoxide dismutase and catalase, which show stability under different environmental conditions.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sourav Kumar Patra, Nilanjan Sinha, Firoz Molla, Ayantika Sengupta, Subhamoy Chakraborty, Souvik Roy, Sanjay Ghosh
Summary: The study revealed that protein tyrosine nitration in Vibrio cholerae decreases under anaerobic and nutrient deprived conditions, with a higher nitrate content compared to nitrite. Nitration may help in cell survival, but V. cholerae lacks nitrite reductase for further nitrite reduction.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Chemistry, Analytical
Abhishek Bhattacharya, Pranjal Biswas, Puranjoy Kar, Piya Roychoudhury, Sankar Basu, Souradipta Ganguly, Sanjay Ghosh, Koustubh Panda, Ruma Pal, Anjan Kr. Dasgupta
ANALYTICA CHIMICA ACTA
(2017)
Article
Biochemistry & Molecular Biology
Puranjoy Kar, Pranjal Biswas, Sanjay Ghosh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Pranjal Biswas, Uddalak Majumdar, Sanjay Ghosh
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)