Article
Plant Sciences
Savita Verma, Ajaswrata Dutta, Akshu Dahiya, Namita Kalra
Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.
Review
Biochemistry & Molecular Biology
Beatriz Castejon-Vega, Mario D. D. Cordero, Alberto Sanz
Summary: In the past, mtROS were seen as byproducts of cellular metabolism and drivers of ageing and age-related diseases. Now, we know that mtROS serve as important cellular messengers, playing a role in maintaining cellular homeostasis and influencing cellular differentiation, proliferation, and survival. However, dysregulated mtROS signaling can contribute to degenerative diseases. This review focuses on the signaling pathways involving mtROS and their role in ageing.
Review
Biochemistry & Molecular Biology
Volodymyr Lushchak, Michael Duszenko, Dmytro Gospodaryov, Olga Garaschuk
Summary: Neural tissue in mammals is a major consumer of oxygen, generating reactive oxygen (ROS) and nitrogen (RNS) species in the brain. These substances play important signaling roles but can also cause damage, particularly during midlife. Understanding the pathways, defense systems, and changes in energy/ROS balance in midlife is crucial for managing neuroinflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Ana Vujic, Amy N. M. Koo, Hiran A. Prag, Thomas Krieg
Summary: Mitochondria play a crucial role in cellular processes and heart function, with communication between mitochondria and the nucleus maintaining cardiomyocyte homeostasis. Excessive generation of ROS can lead to irreversible cell damage, contributing to various pathologies. Additionally, myocardial impairments are associated with specific metabolic changes and dysregulated inflammatory responses.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Qingcai Zhen, Qijian Liang, Hongchun Wang, Yan Zheng, Zhongting Lu, Chunyong Bian, Xiulan Zhao, Xin Guo
Summary: Nonalcoholic steatohepatitis (NASH) is a clinical syndrome characterized by liver inflammation and hepatocyte injury, which is closely related to metabolic disorders. This study investigated the effects of theabrownin, a pigment substance in fermented tea, on NASH. The results showed that theabrownin could improve liver injury, reduce liver inflammatory response, alleviate liver oxidative stress and fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Bermudez-Munoz, Adelaida M. Celaya, Angela Garcia-Mato, Daniel Munoz-Espin, Lourdes Rodriguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Summary: DUSP1 plays a critical role in controlling the cross-talk between oxidative stress and inflammation in sensorineural hearing loss. Knockout of Dusp1 gene in mice accelerates SNHL progression and triggers inflammation, redox imbalance, and hair cell death. N-acetylcysteine treatment delays the onset of SNHL, mitigates cochlear damage, and improves redox balance.
Article
Environmental Sciences
Quan-Kuo He, Chang-Long Xu, Yan-Ping Li, Zhi-Ran Xu, Yu-Shen Luo, Si-Cheng Zhao, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: The study reported that exposure to Captan affected mouse ovarian homeostasis and disrupted female hormone receptor expression, leading to impaired follicular development. Captan exposure also disrupted oocyte development, changing the expression of multiple genes related to autophagy and apoptosis. Additionally, Captan induced oxidative stress, mitochondrial dysfunction, DNA damage, autophagy, and early apoptosis in the ovaries.
Article
Physiology
Tsukasa Okamoto, Evgenia Dobrinskikh, Corinne E. Hennessy, Naoko Liu, Marvin I. Schwarz, Christopher M. Evans, Andrew P. Fontenot, Ivana V. Yang, David A. Schwartz
Summary: This study investigates the role of Muc5b in hypersensitivity pneumonitis (HP) using a mouse model. The researchers found that overexpression of Muc5b increases lung inflammation and fibrosis, while Muc5b deficiency reduces inflammation and fibrosis in the HP model. These findings have implications for understanding the development of HP in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xixi Lai, Masoud Najafi
Summary: Lung toxicity is a major limitation for cancer therapy, with radiotherapy and chemotherapy causing lung injury through the production of reactive oxygen species and nitric oxide. This review explores the cellular and molecular mechanisms of redox-induced lung injury and suggests potential targets and perspectives to mitigate lung toxicity.
CURRENT DRUG TARGETS
(2022)
Article
Cell Biology
Chaeeun Seong, Hyeon Ji Kim, Jin-Seok Byun, Yoonjung Kim, Do-Yeon Kim
Summary: This study investigates the molecular function of FoxO1 in microglia, revealing its role in regulating the redox status, metabolism, and polarization of microglia. These findings provide important insights into the physiology and maintenance of brain homeostasis by microglial cells.
Article
Pharmacology & Pharmacy
Mohamed Elbadawy, Kiwamu Tanabe, Haru Yamamoto, Yusuke Ishihara, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki
Summary: NASH is associated with abnormal mitochondrial function, and this study found that NASH liver organoids showed enhanced metabolism and abnormal mitochondrial morphology. Treatment with the DPR1 inhibitor Mdivi-1 improved morphology and reduced fibrosis-related markers in NASH organoids. Mdivi-1 treatment in NASH model mice also reduced fatty liver and prevented fibrosis and ROS production in the liver.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Filippo Scialo, Alberto Sanz
Summary: Mitochondria are essential for producing energy in cells, but they also generate Reactive Oxygen Species (ROS) which play a critical role in determining cell fate and maintaining cellular homeostasis. Accumulation of defective mitochondria during aging leads to high levels of ROS production, causing oxidative stress and disrupting redox signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Sudarsanan Drishya, Suresh Sulekha Dhanisha, Paramu Raghukumar, Chandrasekharan Guruvayoorappan
Summary: This study investigates the protective effect of dry fruits of the culinary and folkloric spice Amomum subulatum against experimental thoracic radiation-induced esophagitis. The results show that the methanolic extract of A. subulatum dry fruits boosts antioxidant status and reduces radiation-induced oxidative stress, inflammation, and fibrosis in the esophagus.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Environmental Sciences
Si-Cheng Zhao, Zhi-Ran Xu, Chang-Long Xu, Quan-Kuo He, Guang-Ming Yang, Yan-Ping Li, Yu-Shen Luo, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: Exposure to nickel sulfate negatively affects ovarian homeostasis and oocyte quality, triggering ovarian fibrosis and inflammation, and causing structural and functional disorders of mitochondria.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Ekaterina M. Fock, Rimma G. Parnova
Summary: Lipopolysaccharide (LPS) challenge leads to oxidative stress and mitochondrial dysfunction, causing cell and tissue damage. Mitochondrial reactive oxygen species (mtROS) play a key role in inflammation, with excessive levels impairing mitochondrial function and causing oxidative damage. Mitochondria-targeted antioxidants (mito-AOX) have shown promise in protecting against LPS-induced damage and developing new treatment strategies for Gram-negative infections.
Review
Biochemistry & Molecular Biology
Masoud Najafi, Shima Tavakol, Ali Zarrabi, Milad Ashrafizadeh
Summary: Chemotherapy is an important treatment for cancer, but the resistance of cancer cells reduces its effectiveness. Quercetin, a flavonoid compound with high anti-tumour activity, can be used with cisplatin to enhance the efficacy of chemotherapy and reduce its side effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Hossein Moutabian, Ruhollah Ghahramani-Asl, Tohid Mortezazadeh, Reza Laripour, Asghar Narmani, Hamed Zamani, Gholamreza Ataei, Hamed Bagheri, Bagher Farhood, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Nano-curcumin can alleviate doxorubicin-induced cardiotoxicity and improve treatment efficacy.
Review
Oncology
Shahram Taeb, Milad Ashrafizadeh, Ali Zarrabi, Saeed Rezapoor, Ahmed Eleojo Musa, Bagher Farhood, Masoud Najafi
Summary: Cancer is a complex chronic disorder, and the interaction between the tumor microenvironment and immune cells plays a crucial role in tumor treatment and development. Factors such as cancer-associated fibroblasts, extracellular matrix, and hypoxia-inducible factor can enhance the proliferation capacity of cancer stem cells, leading to resistance to treatments such as radiotherapy. Additionally, radiotherapy can affect the release of cytokines and growth factors in the tumor microenvironment, altering local immune responses.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Chemistry, Physical
Akbar Aliasgharzadeh, Vahid Anaraki, Daryoush Khoramian, Mahdi Ghorbani, Bagher Farhood
Summary: This study evaluates the dosimetric characteristics of PASSAG gel dosimeter for different amounts of components in its formulation. It was found that the optimized PASSAG gel dosimeter showed increased sensitivity and excellent linear dose response, with dose resolution values varying in the 0-10 Gy range. Temporal stability in R-2 values was observed during 15-30 days post-irradiation, with R-2 dose sensitivity varying over the 30-day period.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Review
Immunology
Run Yang, Changming Tan, Masoud Najafi
Summary: Cardiovascular disorders are a major concern among individuals undergoing cancer therapy, with heart diseases being a common cause of mortality in these patients. Inflammatory changes and fibrosis are key mechanisms of cardiac diseases following chemotherapy and radiotherapy. Chronic oxidative stress, cell death, and overproduction of pro-inflammatory and pro-fibrosis cytokines are the underlying mechanisms of cardiovascular diseases following cancer therapy.
INFLAMMOPHARMACOLOGY
(2022)
Review
Cell Biology
Zihong Wu, Caidie Zhang, Masoud Najafi
Summary: This article discusses the interaction between anti-tumor immune cells and immunosuppressive cells in the tumor microenvironment, as well as the modulating effects of metformin on various cells and secretions in TME.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Hossein Moutabian, Mehrsa Majdaeen, Ruhollah Ghahramani-Asl, Masoumeh Yadollahi, Esmaeil Gharepapagh, Gholamreza Ataei, Zahra Falahatpour, Hamed Bagheri, Bagher Farhood
Summary: This study aimed to review the potential therapeutic effects of resveratrol in combination with 5-fluorouracil (5-FU) against colorectal cancer. The results demonstrated that co-administration of resveratrol could sensitize the colorectal cancer cells to 5-FU treatment via various mechanisms.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Peyman Amini, Saeedeh Jafari Nodooshan, Milad Ashrafizadeh, Akbar Aliasgharzadeh, Zarichehr Vakili, Saeed Tavakoli, Tayebeh Aryafar, Ahmed Eleojo Musa, Masoud Najafi, Shahram Taeb, Bagher Farhood
Summary: In this study, imperatorin (IMP) was found to enhance the effectiveness of external radiotherapy (ERT) and hyperthermia (HT) in breast cancer cells by increasing the expression of pro-apoptotic genes and reducing the levels of the anti-apoptotic protein Bcl-2, leading to a decrease in cell viability.
CURRENT RADIOPHARMACEUTICALS
(2022)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Article
Immunology
Masoud Moslehi, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Sepideh Rezaei, Nima Rastegar-Pouyani, Emad Jafarzadeh, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi
Summary: The immune system plays a crucial role in the response of cancer cells to anti-cancer agents, as well as the side effects on normal tissues. Modulating immune responses can enhance the effectiveness of anti-tumor therapy and reduce normal tissue toxicity. Melatonin has shown promise in modulating tumor response and alleviating normal tissue toxicity. This review focuses on the immunomodulatory effects of melatonin in both tumor and normal tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Masoud Moslehi, Sepideh Rezaei, Pourya Talebzadeh, Mohammad Javed Ansari, Mohammed Abed Jawad, Abduladheem Turki Jalil, Nima Rastegar-Pouyani, Emad Jafarzadeh, Shahram Taeb, Masoud Najafi
Summary: The incidence of cancer is increasing globally. The long-term adverse effects of cancer therapy and tumor resistance to anticancer agents are major concerns. Apigenin, a plant-derived molecule, has potential as an adjuvant for chemoprevention and overcoming malignancy resistance to cancer therapy. It has promising anti-tumor effects and may reduce genomic instability and risks of second malignancies in normal tissues, as well as improve the efficacy of anticancer modalities.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ehsan Khodamoradi, Shima Afrashi, Karim Khoshgard, Farshid Fathi, Soodeh Shahasavari, Rasool Azmoonfar, Masoud Najafi
Summary: This study aimed to evaluate the effects of simultaneous exposure to Wi-Fi waves and gamma-ray on DNA in peripheral blood lymphocytes. The results showed that simultaneous exposure to Wi-Fi waves and gamma-ray can increase the number of double-strand breaks in DNA in peripheral blood lymphocytes within 72 hours after technetium injection.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daryoush Khoramian, Soroush Sistani, Bagher Farhood
Summary: The study measured systematic and random set-up errors in prostate cancer radiotherapy using EPID and proposed the optimum CTV-to-PTV margin. Results showed population systematic and random errors in different directions, leading to calculated margins based on different formulas, with overall margins averaging at 2.73, 4.98 and 5.86 mm.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2022)
Correction
Engineering, Biomedical
Pooyan Makvandi, Milad Ashrafizadeh, Matineh Ghomi, Masoud Najafi, Hamid Heydari Sheikh Hossein, Ali Zarrabi, Virgilio Mattoli, Rajender S. Varma
PROGRESS IN BIOMATERIALS
(2022)