期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 77, 期 12, 页码 2275-2288出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03402-z
关键词
IKK complex; Stress response; Cytokines; Heat-shock proteins
资金
- Associazione Italiana per la Ricerca sul Cancro [One year fellowship CONAD id.22628] Funding Source: Medline
- Compagnia di San Paolo [Progetti di ricerca di Ateneo 2016] Funding Source: Medline
- Ministero dell'Istruzione, dell'Università e della Ricerca [Progetto di Ricerca PRIN 2015] Funding Source: Medline
The NF-kappa B pathway represents a crucial signaling mechanism in sensing and integrating a multitude of environmental and intracellular stimuli and directing a coordinated response that from the cellular level may impact on the entire organism. A plethora of chaperone proteins work at multiple steps of the pathway, from membrane receptor activation to transcription factor binding to DNA. Indeed, chaperones are required to assist protein conformational changes, to assemble supramolecular complexes and to regulate protein ubiquitination, required for pathway activation. Some chaperones acquired a role as integral components of the signaling complexes, needed for signal progression. Here we describe the chaperones involved in the NF-kappa B pathway and their specific roles in the different contexts.
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