How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo

(2016) Suchitra Matsukura et al.   Cardiovascular Toxicology

Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs

(2016) Xin Cao et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2014) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds-synthesis andin vitrometabolism of deuterated derivatives of dronedadrone

(2013) Joseph Schofield et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting

(2012) David P. Kao et al.   PHARMACOTHERAPY

Celivarone for Maintenance of Sinus Rhythm and Conversion of Atrial Fibrillation/Flutter

(2011) AVINASH R. KHITRI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Effect of dronedarone on Na+, Ca2+ and HCN channels

(2011) Roman Bogdan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dronedarone in High-Risk Permanent Atrial Fibrillation

(2011) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology

(2009) A. Arya et al.   EUROPACE

Effect of Dronedarone on Cardiovascular Events in Atrial Fibrillation

(2009) Stefan H. Hohnloser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensitive and reliable proarrhythmiain vivoanimal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

(2008) A Sugiyama   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs

(2008) Tomomichi Ishizaka et al.   CIRCULATION JOURNAL

Increased Mortality after Dronedarone Therapy for Severe Heart Failure

(2008) Lars Køber et al.   NEW ENGLAND JOURNAL OF MEDICINE