Article
Endocrinology & Metabolism
Feifei Zhou, Nannan Du, Lulin Zhou, Chenxi Wang, He Ren, Qiang Sun
Summary: This meta-analysis demonstrates that sotagliflozin has an acceptable safety profile in patients with diabetes, with adverse events including genital mycotic infection, related-to-acidosis events, diarrhea, volume depletion, and severe nocturnal hypoglycemia events. The subgroup analysis of sotagliflozin dosage is of great clinical significance for guiding the use of sotagliflozin in patients with diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Liu, Yue Gao, Ying-Kun Guo, Chun-Chao Xia, Rui Shi, Li Jiang, Meng-Ting Shen, Lin-Jun Xie, Wan-Lin Peng, Wen-Lei Qian, Ming-Yan Deng, Li-Ling Deng, Yan Ren, Zhi-Gang Yang
Summary: The objective of this study was to evaluate myocardial fibrosis using cardiac magnetic resonance (CMR) T1 mapping in type 2 diabetes mellitus (T2DM) patients and investigate the association between left ventricular (LV) subclinical myocardial dysfunction and myocardial fibrosis. The results showed that T1 mapping could detect abnormal myocardial fibrosis early in patients with T2DM, which can cause a decline in the LV diastolic function. The study also found an independent association between diabetes duration and extracellular volumes (ECVs).
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Carolyn S. P. Lam, Chinthanie Ramasundarahettige, Kelley R. H. Branch, Naveed Sattar, Julio Rosenstock, Richard Pratley, Stefano Del Prato, Renato D. Lopes, Elisabeth Niemoeller, Nardev S. Khurmi, Seungjae Baek, Hertzel C. Gerstein
Summary: The analysis of the AMPLITUDE-O trial suggests that the efficacy and safety of Efpeglenatide are not impacted by concurrent use of SGLT2 inhibitors. These data support the combined use of SGLT2 inhibitors and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes.
Article
Medicine, General & Internal
Seul-Gee Lee, Darae Kim, Jung-Jae Lee, Hyun-Ju Lee, Ro-Kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-Ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong, Jung-Sun Kim
Summary: In a diabetic animal model, dapagliflozin attenuated left ventricular diastolic dysfunction and cardiac fibrosis through regulation of SGK1 signaling. It also exhibited anti-inflammatory effects and ameliorated mitochondrial disruption.
Article
Cardiac & Cardiovascular Systems
Rahul Aggarwal, Deepak L. Bhatt, Michael Szarek, Christopher P. Cannon, Darren K. Mcguire, Silvio E. Inzucchi, Renato D. Lopes, Michael J. Davies, Phillip Banks, Bertram Pitt, Philippe Gabriel Steg
Summary: This study assessed the efficacy of Sotagliflozin on heart failure clinical outcomes in individuals with different baseline glycosylated hemoglobin levels. The results showed that Sotagliflozin reduced heart failure outcomes, regardless of baseline HbA1c.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Saki Todo, Hidekazu Tanaka, Yuki Yamauchi, Shun Yokota, Yasuhide Mochizuki, Hiroaki Shiraki, Kentaro Yamashita, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Yusuke Tanaka, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata
Summary: Subclinical right ventricular systolic dysfunction was observed in patients with type 2 diabetes mellitus and preserved left ventricular ejection fraction, and it was associated with left ventricular longitudinal myocardial dysfunction.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Edouard L. Fu, Elisabetta Patorno, Brendan M. Everett, Muthiah Vaduganathan, Scott D. Solomon, Raisa Levin, Sebastian Schneeweiss, Rishi J. Desai
Summary: This study aimed to evaluate the comparative effectiveness of SGLT2i vs. sitagliptin in older adults with HF and type 2 diabetes and found that initiating SGLT2i was associated with a lower risk of the primary composite outcome compared to sitagliptin.
EUROPEAN HEART JOURNAL
(2023)
Review
Endocrinology & Metabolism
Sha Zhang, Zhan Qi, Yidong Wang, Danfei Song, Deqiu Zhu
Summary: SGLT2 inhibitors have positive effects on weight loss and fat reduction in patients with type 2 diabetes, but they may also cause muscle mass loss and increase the risk of sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuki Yamauchi, Hidekazu Tanaka, Shun Yokota, Yasuhide Mochizuki, Yuko Yoshigai, Hiroaki Shiraki, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata
Summary: High heart rate is independently associated with LV longitudinal myocardial dysfunction in asymptomatic patients with type 2 diabetes mellitus and preserved LV ejection fraction. The combination of heart rate with other clinical variables improves the assessment of LV function in these patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Weronika Frak, Joanna Hajdys, Ewa Radzioch, Magdalena Szlagor, Ewelina Mlynarska, Jacek Rysz, Beata Franczyk
Summary: Cardiovascular diseases (CVD) are a major global health concern, and sodium/glucose cotransporter 2 (SGLT2) inhibitors have emerged as a promising class of medications for managing CVD. In this paper, we discuss the role of various SGLT-2 inhibitors as potential therapeutic targets for cardiovascular diseases, highlighting their significant cardiovascular benefits and renal protection. These novel therapeutic approaches aim to improve patient outcomes and reduce the burden of these conditions, but further studies are needed to explore the scientific advancements and mechanisms.
Article
Geriatrics & Gerontology
Hiroshi Akasaka, Ken Sugimoto, Ayumi Shintani, Satsuki Taniuchi, Koichi Yamamoto, Katsuomi Iwakura, Atsunori Okamura, Shin Takiuchi, Masahiro Fukuda, Kei Kamide, Yasushi Fujio, Satoshi Nakatani, Toshio Ogihara, Hiromi Rakugi
Summary: In this randomized controlled study focusing on patients with type 2 diabetes and heart failure with preserved ejection fraction, 24-week treatment with ipragliflozin did not improve left ventricular diastolic function compared to conventional treatment. In subgroup analysis, ipragliflozin treatment led to a decrease in left ventricular mass index in participants aged 70 and above.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Linong Ji, Xiaozhen Jiang, Qingshun Hao, Zhifeng Cheng, Kun Wang, Shuguang Pang, Meiying Liu, Yushan Guo, Xiaowen Chen, Xiuhai Su, Tao Ning, Jie Liu, Fang Bian, Yulan Li, Zhinong Zhang, Weihong Song, Jingfang Sun
Summary: This study evaluated the efficacy and safety of janagliflozin as monotherapy for Chinese patients with type 2 diabetes mellitus. The results showed that janagliflozin effectively improved glycemic control, reduced body weight and blood pressure, and was well tolerated.
DIABETES OBESITY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Bo Xu, Shaoqian Li, Bo Kang, Jiecan Zhou
Summary: This article examines the clinical benefit, safety, and tolerability of the four SGLT2 inhibitors approved by the US FDA for the treatment of type 2 diabetes mellitus. SGLT2 inhibitors reduce hyperglycemia by increasing urinary glucose excretion and improving beta-cell function. Early clinical trials have shown their beneficial effects with acceptable safety and excellent tolerability.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Health Care Sciences & Services
Yan-Rong Li, Chi-Hung Liu, Wei-Chiao Sun, Pei-Yi Fan, Feng-Hsuan Liu, Tien-Hsing Chen, Victor Chien-Chia Wu, Chihung Lin, Ching-Chung Hsiao
Summary: This study found that the combination therapy of SGLT-2 inhibitors and Pio in T2DM patients did not increase the risk of bladder cancer and was associated with lower all-cause mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Yi-Wen Yu, Xue-Mei Zhao, Yun-Hong Wang, Qiong Zhou, Yan Huang, Mei Zhai, Jian Zhang
Summary: The study found that SGLT2 inhibitors had no significant impact on cardiac structural parameters in type 2 diabetes patients, but improved left ventricular ejection fraction in heart failure patients. It also had a positive effect on cardiac diastolic function, plasma NT-proBNP level, and KCCQ score.
CARDIOVASCULAR DIABETOLOGY
(2021)