期刊
CARBON
卷 164, 期 -, 页码 451-458出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2020.02.028
关键词
Coenzyme Q(10); Carbon aerogel; Drug loading; Lipophilic; Graphene; Graphene oxide
资金
- University of Washington Materials Science and Engineering
- ACS Petroleum Research Fund [52582-DNI10]
- U.S. Department of Energy
- Fundamental & Computational Sciences Division of the Pacific Northwest National Laboratory (PNNL)
- Battelle [DE-AC05-76RL01830]
- Materials Synthesis and Simulation across Scales (MS3) Initiative
- Laboratory Directed Research and Development (LDRD) in PNNL
- National Science Foundation (CAREER Award) [1555007]
- National Science Foundation [ECC-1542101]
- University ofWashington
- Molecular Engineering & Sciences Institute
- Clean Energy Institute
- National Institutes of Health
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1555007] Funding Source: National Science Foundation
Low-density aerogel materials are a promising platform for delivering lipophilic drugs with poor water solubility, but to date, the loading of aerogels with pharmaceuticals in crystalline form has not been reported other than by expensive supercritical loading techniques. Here, we demonstrate a simple and low-cost liquid-phase impregnation method to load the model drug coenzyme Q(10) (CoQ(10)) within carbon aerogels. By controlling the chemical microstructure of the aerogel to exhibit pi-conjugated (sp(2)) bonding via addition of graphene oxide, the rate of adsorption and total loading of CoQ(10) is significantly enhanced. Furthermore, the adsorbed CoQ(10) adopts an as-yet unreported crystalline phase that differs from the bulk material, not only offering the potential advantages of crystalline materials for drug delivery, but also a means to control the microstructure of this important lipophilic pharmaceutical. (C) 2020 Elsevier Ltd. All rights reserved.
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