Article
Chemistry, Applied
Tomasz Machalowski, Joanna Idaszek, Adrian Chlanda, Marcin Heljak, Adam Piasecki, Wojciech Swieszkowski, Teofil Jesionowski
Summary: The study developed chitin-based biocomposites through biomimetic ex vivo deposition of calcium carbonate particles in the hemolymph from the cultivated mollusk Cornu aspersum and chitinous matrix from the marine demosponge Aplysina fistularis. The results showed that the biofunctionalized scaffold had about 4 times higher mechanical resistance and exhibited significant topographical changes, indicating its potential for modifying cell delivery systems in future biomedical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Esam Bashir Yahya, A. A. Amirul, Abdul H. P. S. Khalil, Niyi Gideon Olaiya, Muhammad Omer Iqbal, Fauziah Jummaat, Atty A. K. Sofea, A. S. Adnan
Summary: The global transplant market is growing steadily, with researchers seeking alternative approaches for tissue transplantation. Biopolymer aerogel scaffolds play a significant role in tissue engineering and regenerative medicine, aiding in the regeneration of skin, cartilage, bone, and other tissues.
Article
Engineering, Biomedical
Silke Keller, Tomke Bakker, Benjamin Kimmel, Lisa Rebers, Tobias Goetz, Guenter E. M. Tovar, Petra J. Kluger, Alexander Southan
Summary: By functionalizing gelatin with azides, it can be covalently immobilized in hydrogels, improving the efficiency of using biological materials. Experimentally validated, this new gelatin derivative is not only noncytotoxic to cells, but also significantly enhances cell adhesion on the material surface.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Engineering, Chemical
Mariana Chelu, Adina Magdalena Musuc
Summary: Biomaterials are natural and synthetic materials compatible with the human body. They are widely used in the medical field for various purposes. This review provides an overview of the classification, applications, and challenges in the field of biomaterials.
Article
Chemistry, Medicinal
Olimpia Ortiz-Arrabal, Ainhoa Irastorza-Lorenzo, Fernando Campos, Miguel Angel Martin-Piedra, Victor Carriel, Ingrid Garzon, Paula Avila-Fernandez, Maria Jose de Frutos, Emilio Esteban, Javier Fernandez, Agustin Janer, Antonio Campos, Jesus Chato-Astrain, Miguel Alaminos
Summary: Marine-origin polysaccharides, especially agarose, have been extensively studied as scaffolds for tissue engineering. We have developed new fibrin-agarose (FA) biomaterials using different types and concentrations of agaroses, which showed high biocompatibility and varied biomechanical properties. In vivo experiments demonstrated the biocompatibility of FA tissues and histological analysis indicated a pro-regenerative process with M2-type CD206-positive macrophages. These findings confirm the clinical potential of FA biomaterials for tissue engineering applications, allowing for the selection of specific agarose types and concentrations to meet desired biomechanical properties and in vivo reabsorption times.
Article
Polymer Science
Irina Tyshkunova, Iosif Gofman, Dmitry G. Chukhchin, Alexey Malkov, Alexander Mishanin, Alexey S. Golovkin, Ekaterina N. Pavlova, Daria N. Poshina, Yury A. Skorik
Summary: The study found that cellulose cryogels with chitin nanowhiskers showed a threefold increase in strength and better biocompatibility compared to normal cellulose cryogels.
Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Chemistry, Multidisciplinary
Oystein Arlov, Dominic Rutsche, Maryam Asadi Korayem, Ece Ozturk, Marcy Zenobi-Wong
Summary: Sulfated polysaccharides play central roles in biological functions, and engineered sulfated polysaccharides exhibit novel and augmented biological properties through facilitating interactions with other macromolecules.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Adriana Gilarska, Alicja Hinz, Monika Bzowska, Grzegorz Dyduch, Kamil Kaminski, Maria Nowakowska, Joanna Lewandowska-Lancucka
Summary: Novel multifunctional biomimetic injectable hybrid systems have been synthesized, showing promise for bone tissue regeneration. These systems can be injected precisely into diseased tissue, serving as scaffolds for locally controlled bone tissue regeneration and remodeling while maintaining optimal bone cell levels. They are especially useful for repairing small osteoporotic bone defects and lack systemic toxicity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Engineering, Biomedical
Leila Daneshmandi, Mohammed Barajaa, Armin Tahmasbi Rad, Stefanie A. Sydlik, Cato T. Laurencin
Summary: Graphene and its derivatives have attracted global attention for their unique characteristics, especially in the field of biomedical applications. This review article comprehensively explores the usage of graphene-based materials in bone regenerative engineering, discussing their applications as fillers in composites, coatings for scaffolds and implants, and delivery vehicles for therapeutic agents. The safety, biocompatibility, and future prospects of graphene materials in regenerative engineering are also evaluated.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Isadora C. Carvalho, Herman S. Mansur, Alice G. Leonel, Alexandra A. P. Mansur, Zelia I. P. Lobato
Summary: This review discusses the current progress in designing and developing polysaccharide-based biomaterials for brain tissue repair and regeneration. Polysaccharides have the potential to enhance advanced technologies in this field by interacting with a variety of biomolecules, including glycosaminoglycans and signaling moieties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Goran M. Stojanovic, Mohd Faizal Bin Abdullah, Alireza Dolatshahi-Pirouz, Hany E. Marei, Nureddin Ashammakhi, Anwarul Hasan
Summary: Tissue engineering is an advanced biomedical approach that utilizes smart hydrogels to repair and regenerate damaged tissues, treating patients with lost or failed organs or tissues. These hydrogels offer controllable properties, such as tunable mechanical characteristics and biocompatibility, making them ideal for tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Polymer Science
Sabrina Kopf, Dan Akesson, Mikael Skrifvars
Summary: Polyhydroxyalkanoates (PHAs) have great potential in biomedical applications, especially tissue engineering, due to their superior biocompatibility and biodegradability. Textile fiber-based tissue engineering scaffolds can mimic the properties of native tissues, and combining them with PHAs can improve performance. However, the complex crystallization behavior of PHAs and the resulting spinning procedures are still challenging. Additionally, the biomedical application of PHAs is hindered by insufficient polymer purity.
Review
Chemistry, Multidisciplinary
Federico Fontana, Fabrizio Gelain
Summary: The advent of supramolecular biopolymers has brought promising opportunities for tissue engineering, due to their tailorability, absence of toxic byproducts, and better mimicry of extracellular matrix nanotopography and mechanical properties. However, there is still a lack of understanding of their properties at meso- and macroscales. In this review, molecular modeling approaches are discussed, highlighting their advantages and limitations in representing and transferring the properties of supramolecular biopolymers.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Polymer Science
Kiran M. Ali, Yihan Huang, Alaowei Y. Amanah, Nasif Mahmood, Taylor C. Suh, Jessica M. Gluck
Summary: This study evaluates the potential use of traditional textile methods in the tissue engineering industry and proves the safety and efficacy of the material and fabrication method by creating collagen yarns using the traditional ring spinning method. The process is not only simple and efficient but also results in standardized products.
Review
Engineering, Environmental
Muhammad Bilal, Ehsan Ullah Rashid, Jakub Zdarta, Teofil Jesionowski
Summary: Graphene and graphene-based nanostructured materials have attracted great interest in diverse fields due to their extensive surface area and unique physicochemical attributes. They have been utilized in energy storage, catalysis, environmental sensing, and remediation. Functionalization of graphene nanostructures enables the immobilization of biological molecules and enzymes, leading to enhanced performance. Graphene-based nanomaterials also show promise as support matrices for multifunctional nanobiocatalytic systems in various biotechnological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Anil Kumar Singh, Muhammad Bilal, Teofil Jesionowski, Hafiz M. N. Iqbal
Summary: Lignin-modifying enzymes (LMEs) are important biocatalysts in environmental remediation. This study used predictive toxicological and computational frameworks to assess the hazards of pollutants and predict their degradation using LMEs.
Article
Environmental Sciences
Ahmad Farhan, Javeria Arshad, Ehsan Ullah Rashid, Haroon Ahmad, Shahid Nawaz, Junaid Munawar, Jakub Zdarta, Teofil Jesionowski, Muhammad Bilal
Summary: Photocatalytic degradation is a promising technology for removing synthetic and organic pollutants. Fe2O3 has emerged as a fascinating material for this purpose due to its bandgap, light-harvesting efficiency, renewability, and stability. This study reviews the efficiency and applications of Fe2O3-based nanocomposites for water remediation, as well as their electrocatalytic properties. The ongoing issues and future prospects of Fe2O3-based catalysts are also discussed.
Article
Oncology
Gerald Steiner, Roberta Galli, Grit Preusse, Susanne Michen, Matthias Meinhardt, Achim Temme, Stephan B. Sobottka, Tareq A. Juratli, Edmund Koch, Gabriele Schackert, Matthias Kirsch, Ortrud Uckermann
Summary: In this study, infrared spectroscopy was used to identify brain tumors. The classification model developed based on IR spectra successfully classified 82% of tumor and non-tumor samples, with high accuracy for different types of brain tumors. This approach could accelerate the clinical translation of infrared spectroscopy and enable the detection of multiple brain tumor types using a single instrument in future clinical settings.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Sara Mellid, Eduardo Gil, Rocio Leton, Eduardo Caleiras, Emiliano Honrado, Susan Richter, Nuria Palacios, Marcos Lahera, Juan C. Galofre, Adria Lopez-Fernandez, Maria Calatayud, Aura D. Herrera-Martinez, Maria A. Galvez, Xavier Matias-Guiu, Milagros Balbin, Esther Korpershoek, Eugenie S. Lim, Francesca Maletta, Sofia Lider, Stephanie M. J. Fliedner, Nicole Bechmann, Graeme Eisenhofer, Letizia Canu, Elena Rapizzi, Irina Bancos, Mercedes Robledo, Alberto Cascon
Summary: In recent years, it has been found that a significant percentage of PPGL patients carry known germline mutations in susceptibility genes. Furthermore, some patients with mutations in the NF1 gene also have co-occurring mutations in other PPGL related genes, which may play a role in tumor development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Engineering, Environmental
Agnieszka Slosarczyk, Izabela Klapiszewska, Dagmara Skowronska, Marcin Janczarek, Teofil Jesionowski, Lukasz Klapiszewski
Summary: The biological deterioration of construction materials and the need for antimicrobial properties in buildings are important issues. Metal and metal oxide nanoparticles can improve the resistance of building materials to biological factors by providing antimicrobial functions. The combination of these nanoparticles with the cement matrix may also impact the durability of construction materials. This article focuses on the antimicrobial efficacy of metal nanoparticles and metal oxides in public buildings, such as hospitals, and analyzes the incidence of microorganisms in different regions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Endocrinology & Metabolism
Nicole Bechmann, Frank Westermann, Graeme Eisenhofer
Summary: Pediatric neural crest-derived adrenal neoplasms, such as neuroblastoma and pheochromocytoma, exhibit clinical heterogeneity with varying outcomes. Increased HIF2α expression and MYCN amplification contribute to aggressiveness and poor prognosis. Understanding HIF and MYC signaling pathways can provide insights into tumorigenesis and potential therapeutic targets for these pediatric adrenal neoplasms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Zohaib Saddique, Muhammad Imran, Ayesha Javaid, Shoomaila Latif, Tak H. Kim, Marcin Janczarek, Muhammad Bilal, Teofil Jesionowski
Summary: Although rapid industrialization has brought convenience to human life, it has also caused various environmental issues, with wastewater being regarded as one of the key problems of the 21st century. The use of bismuth-based nanomaterials synthesized through biosynthesis methods, such as using plants, bacteria, and fungi, has shown promise in wastewater treatment for its eco-friendliness and cost-effectiveness. This review focuses on elaborating the biosynthesis of bismuth-based nanomaterials and their application in wastewater treatment as anti-pathogens and photocatalysts for pollutant degradation, as well as presenting future research perspectives and concluding remarks.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agricultural Engineering
Przemyslaw Bartczak, Marcin Wysokowski, Kacper Szylinczuk, Majka Odalanowska, Teofil Jesionowski, Slawomir Borysiak
Summary: This study focuses on the utilization of sustainable chitin-lignin filler for polyurethanes in order to produce sustainable, cost-effective, and efficient foam materials. The addition of chitin-lignin filler improved the mechanical properties of the polyurethane foams, particularly in seat foam production.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Anil Kumar Singh, Hafiz M. N. Iqbal, Nunzio Cardullo, Vera Muccilli, Jesus Fernandez-Lucas, Jens Ejbye Schmidt, Teofil Jesionowski, Muhammad Bilal
Summary: Lignin modifying enzymes (LMEs) have been widely recognized for their ability to depolymerize lignin polymers through oxidative cleavage. LMEs include enzymes such as lignin peroxidase, manganese peroxidase, versatile peroxidase, laccase, and dye-decolorizing peroxidase, and they have been extensively studied for their applications in lignin valorization and oxidative cleavage of xenobiotics and phenolics. Although LMEs have garnered significant attention in biotechnology and industry, their potential future applications are still underexplored. Further research is needed to fully understand the underlying mechanism of LMEs and their potential for sustainable pollution mitigation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Anke Witt, Ivona Mateska, Alessandra Palladini, Anupam Sinha, Michele Woelk, Akiko Harauma, Nicole Bechmann, Christina Pamporaki, Andreas Dahl, Michael Rothe, Irakli Kopaliani, Christian Adolf, Anna Riester, Ben Wielockx, Stefan R. Bornstein, Matthias Kroiss, Mirko Peitzsch, Toru Moriguchi, Maria Fedorova, Michal Grzybek, Triantafyllos Chavakis, Peter Mirtschink, Vasileia Ismini Alexaki
Summary: Corticosteroids play a crucial role in regulating various physiological processes, and their production is influenced by the polyunsaturated fatty acid (PUFA) content in mitochondrial phospholipids in adrenocortical cells. Inhibition of the enzyme FADS2, which is involved in PUFA synthesis, disrupts mitochondrial lipid composition and reduces steroidogenesis. FADS2 expression is elevated in obese mice, leading to increased corticosterone levels, but this can be countered by using FADS2 inhibitors or PUFA supplementation. Furthermore, FADS2 expression is elevated in aldosterone-producing adenomas in humans, indicating its role in adrenal steroidogenesis in health and disease.
Article
Oncology
Alessa Fischer, Umberto Maccio, Katharina Wang, Juliane Friemel, Martina A. Broglie Daeppen, Diana Vetter, Kuno Lehmann, Astrid Reul, Mercedes Robledo, Constanze Hantel, Nicole Bechmann, Karel Pacak, Kathrin Zitzmann, Christoph J. Auernhammer, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: In pheochromocytomas and paragangliomas, hypoxia upregulates the expression of PD-L1 and HIF-2 alpha, promoting tumor progression and immune microenvironment alterations. Head and neck paragangliomas undergoing embolization show significantly higher expression levels of PD-L1 and HIF-2 alpha, suggesting that targeted treatment using HIF-2 alpha and checkpoint inhibitors may be beneficial.
Article
Chemistry, Analytical
Maria Kuznowicz, Tomasz Rebis, Artur Jedrzak, Grzegorz Nowaczyk, Teofil Jesionowski
Summary: A novel catechol-based PCA@MWCNT-Ni(OH)(2) hybrid material was developed and used for non-enzymatic glucose biosensing. The hybrid material showed enhanced redox properties and electrocatalytic activity for glucose detection. The nonenzymatic glucose biosensor exhibited a low detection limit, high selectivity, wide linear range, good stability, and reproducibility.
Article
Chemistry, Multidisciplinary
Marcin Wysokowski, Tomasz Machalowski, Joanna Idaszek, Adrian Chlanda, Jakub Jaroszewicz, Marcin Heljak, Michal Niemczak, Adam Piasecki, Marta Gajewska, Hermann Ehrlich, Wojciech Swieszkowski, Teofil Jesionowski
Summary: Tissue engineering is a growing field that aims to repair damaged tissues by combining cells with scaffold biomaterials. Carbon materials have emerged as superior materials in this context. This study proposes a method to produce a 3D carbon-based scaffold that mimics the structural features of spongin. The scaffold exhibits excellent structural characteristics and biocompatibility, making it a promising candidate for stem cell-based tissue engineering.
Article
Microbiology
Omkar Pokharkar, Harshavardhan Anumolu, Grigory V. Zyryanov, Mikhail V. Tsurkan
Summary: The aim of this research was to identify natural products (NPs) with potential anti-SARS-CoV-2 activity. Using molecular docking and simulations, nine shortlisted NPs were found to exhibit strong interactions with key residues in the AS1 and AS2 regions of RdRp. Among them, bromophycoic acid C showed promising dual inhibition by interacting favorably with nsp15 protein and the N-terminal of RdRp.
MICROBIOLOGY RESEARCH
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
