Article
Chemistry, Multidisciplinary
Yuan Yuan Liu, Xin Zhang, Kai Li, Qiu Chen Peng, Yu Jing Qin, Hong Wei Hou, Shuang Quan Zang, Ben Zhong Tang
Summary: The study reports butterfly-like molecules of OAP with typical AIE characteristics achieved through the RIV mechanism. OAP AIEgens can be synthesized easily using commercially available materials, making them ideal ligands for constructing MOFs. The OAP-based MOFs have potential applications in gas response, information storage, and white light-emitting devices.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Lifeng Xu, Qingye Meng, Zhenqian Zhang, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: In this study, an aggregation-induced emission (AIE) material based on the Schiff base compound of chitosan and salicylaldehyde was designed and synthesized. The material demonstrated potential applications in the biomedical field, including biosensing and antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Feilin Lin, Haifang Liu, Qichang Zhou, Siqi Zhang, Yang Zhou, Yuhong Feng, Jiacheng Li
Summary: In this study, amphiphilic alginate conjugated with aggregation-induced emission (AIE) moiety fluorescent polymer was successfully synthesized, showing excellent biocompatibility and bioimaging properties. The fluorescent particles exhibited multicolor fluorescence emission in both solid and solution states, and demonstrated potential applications in direct visualization of leaf stomata and drug delivery of hydrophobic curcumin. These results suggest promising opportunities for further utilization of alginate in understanding various biological systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Zhao Li, Xiaofan Ji, Huilin Xie, Ben Zhong Tang
Summary: Chromophores with aggregation-induced emission (AIEgens) display intense fluorescence in their aggregated states but minimal emission in solution as discrete molecules due to changes in intramolecular motions. Gels, as solvent-swollen quasi-solids, manipulate intramolecular motions and have attracted significant interest for their unique properties and promising applications. The comprehensive overview covers fabrication strategies, applications, functions, structure-property relationships of AIE-active gels, diverse areas of applications, ongoing challenges, potential means to address them, and future perspectives to inspire research on novel materials and ideas.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Applied
Lifeng Xu, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Soy protein isolate (SPI) as an unconventional luminescent material, has excellent properties and potential broad application prospects, including AIE and CTE mechanisms, room temperature phosphorescence, which can be used in biosensors and multi-channel imaging.
Review
Engineering, Biomedical
Yuqing Wang, Bozhang Xia, Qianqian Huang, Ting Luo, Yuanyuan Zhang, Peter Timashev, Weisheng Guo, Fangzhou Li, Xing-Jie Liang
Summary: Considerable efforts have been made in developing nano-therapeutic systems containing aggregation-induced emission fluorogens (AIEgens) due to their excellent properties. Recent literature reviews highlight the increasing research activities on AIEgens-containing systems in various biomedical applications, emphasizing their advantages and reasons for selection.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Zipeng Shen, Wei Zhu, Yajia Huang, Jiangjiang Zhang, Yifan Wu, Yinzhen Pan, Guang Yang, Dong Wang, Ying Li, Ben Zhong Tang
Summary: To address the issue of multidrug-resistant (MDR) bacteria-related wound infections, researchers have developed a new antibacterial wound dressing that can prevent MDR bacteria infection and promote wound healing. The composite of aggregation-induced emission (AIE) molecule BITT and bacterial cellulose (BC) shows good transparency and allows for monitoring the wound healing process. The BC-BITT composites exhibit photodynamic and photothermal synergistic antibacterial effects under 660 nm laser irradiation and demonstrate excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, with negligible toxicity. This work provides a new approach for treating clinically troublesome wound infections.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yunhui Liao, Ruolan Wang, Shaozhen Wang, Yifan Xie, Huanhao Chen, Runjia Huang, Longquan Shao, Qiuhua Zhu, Yanshan Liu
Summary: The new AIE-active Schiff base TBTDC NPs exhibit good biocompatibility, impressive two-photon bioimaging capability, high O-1(2) generation quantum yield, specific targeting, and photostability in PDT. They also show remarkable cytotoxicity for tumor cells and potential for suppressing tumor growth in nude mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Xin Hu, Shengxian Yu, Guang Yang, Wei Long, Teng Guo, Jianwen Tian, Meiying Liu, Xiancai Li, Xiaoyong Zhang, Yen Wei
Summary: This study designed and synthesized a novel chitosan-based fluorescent copolymer, which showed good biocompatibility and low toxicity, exhibited intense AIE feature, and had potential applications in biological imaging and intracellular drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Qing Yu, Luyao Tian, Wenya Su, Xia Li, Juan Wang, Lanping Guo, Luqi Huang, Wenyuan Gao
Summary: Photodynamic therapy (PDT) is a promising adjuvant therapy for cancer. However, the aggregation of organic photosensitizers in biological systems limits its efficacy. A newly developed self-assembled nanoplatform has addressed this issue and successfully delivered rapamycin. This multifunctional platform combines photodynamic therapy with tumor microenvironment remodeling, making it a forward-looking PDT design strategy.
ACS MATERIALS LETTERS
(2023)
Review
Engineering, Biomedical
Jiaqiang Wang, Liyao Zhang, Zhen Li
Summary: This review first summarizes the organic compounds with AIE features for biomedical applications and design strategies for photoresponsive AIE luminogens (AIEgens) briefly. Then it discusses in depth the applications of photoresponsive and AIE-active molecules in photoactivation imaging, super-resolution imaging, light-induced drug delivery, photodynamic therapy with photochromic behavior, and bacterial targeting and killing. Finally, it considers the future outlook for AIEgens to stimulate innovative work for further development in this field.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jian-Gang Yu, Li-Ying Sun, Chong Wang, Yang Li, Ying-Feng Han
Summary: The coordination-driven self-assembly with TPE units has attracted much attention for applications in chemical sensors, cell imaging agents, light-harvesting systems, etc., thanks to the potential of aggregation-induced emission (AIE) phenomena. Recent advances have been made in the design and application of TPE-based metallacycles, metallacages, metal-organic frameworks (MOFs) and coordination polymers (CPs), leading to improved stabilities and enhanced chemical responses exhibited by the products.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Polymer Science
Yunfei Zuo, Ryan T. K. Kwok, Jianwei Sun, Jacky W. Y. Lam, Ben Zhong Tang
Summary: Recent advancements in aggregation-induced emission (AIE) macromolecular materials have received attention as potential antibacterial solutions, providing new approaches for treating multidrug-resistant infections and biofilms, as well as real-time monitoring and specific targeting of bacteria. This review discusses the three main categories of AIE macromolecular materials with antibacterial properties and their mechanisms and applications in antibacterial treatment, wound care, and protective equipment. It also highlights the potential for future developments and application directions of AIE-based antimicrobial materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Qiaojun Qu, Zeyu Zhang, Xiaoyong Guo, Junying Yang, Caiguang Cao, Changjian Li, Hui Zhang, Pengfei Xu, Zhenhua Hu, Jie Tian
Summary: This study developed a powerful phototheranostic agent that can accurately detect and eliminate microscopic residual tumors intraoperatively, proposing a novel integrated strategy for complete tumor eradication.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ming Hui Chua, Kang Le Osmund Chin, Xian Jun Loh, Qiang Zhu, Jianwei Xu
Summary: The discovery of aggregation-induced emission (ALE) phenomenon in 2001 has led to significant advancements in materials development across various research fields. ALE-active materials have found wide applications in optoelectronics, sensing, biomedical, and stimuli-responsive systems through integration with nanoscience and nanotechnology. This review article summarizes the latest research efforts in ALE-based nanomaterials, highlighting their synthesis and nonbiomedical applications, and provides an outlook on the future of ALE-based nanostructured materials in diverse fields beyond biomedicine.
Article
Chemistry, Physical
Chengyang Xiong, Yan Li, Jian Zhang, Yu Wang, Wentao Qu, Yuancao Ji, Lishan Cui, Xiaobing Ren
Summary: A unique metastable beta-Ti shape memory alloy with classic superelasticity over a wide temperature range is presented in this study. The superelasticity is experimentally verified to originate from two concurrent nano-scale transitions, providing potential for advanced applications and designs of beta-Ti based SMAs.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Physical
Yujie Zhao, Qiquan Li, Yan Li
Summary: Highly oriented and self-ordered titanium-niobium-iron mixed oxide nanotubes were synthesized through an electrochemical route, with their nanostructure morphologies closely related to the nature of the alloy substrates. Under solar irradiation, the methylene blue degradation rate of Ti-Nb-Fe-O nanotubes increased by 33% compared to TiO2 nanotubes and TiO2 nanoparticle films. The gully-like morphology and rich defects introduced by Nb and Fe co-doping in Ti-Nb-Fe-O mixed nanotube oxides contribute to enhanced photocatalytic degradation performance.
Article
Environmental Sciences
Yujie Zhao, Yan Li, Lidong Sun
Summary: Photoinduced reduction and oxidation play important roles in photocatalytic water splitting and organic degradation, attracting increasing interest in recent years. Focus is placed on enhanced light absorption, efficient charge separation, and interfacial reaction through bandgap and interfacial engineering. Key strategies for hydrogen evolution and degradation of emerging pollutants are discussed in this review.
Article
Materials Science, Multidisciplinary
Jingru Gao, Yanze Bi, Xianda Xue, Hongyan Yu, Yang Zheng, Yan Li
Summary: The corrosion resistance of high-purity Mg was significantly enhanced by surface modification with laser scanning and PCL spin coating. The combined treatment reduced weight loss after 28-day immersion, showing great potential for practical applications.
Article
Chemistry, Multidisciplinary
Zhenzhen Dong, Jinbo Fei, Tonghui Wang, Xia Xu, Weiguang Dong, Junbai Li
Summary: In this study, a natural-artificial hybrid structure was constructed to enhance photosynthesis in chloroplast using black phosphorus nanosheets. The oxygen produced during photosynthesis promoted the photoreaction of black phosphorus nanosheets, leading to an improved efficiency of photosynthesis.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Metallurgy & Metallurgical Engineering
Jianliang Zhao, Hanrui Cui, Zeyu Gao, Yanze Bi, Zhenzhen Dong, Yan Li, Caiqi Wang
Summary: This study proposes an integrated strategy based on pH and Mg2+ changes triggered by magnesium degradation to overcome the rapid degradation and infection issues of biomedical magnesium. The system provides simultaneous anticorrosion and antibacterial activity, with controllable antimicrobial properties. By coating magnesium with polydopamine, an intelligent platform is constructed to reduce the swelling degree of the coating, exhibiting superior corrosion resistance. The material shows effective antibacterial ability and high biocompatibility, offering broader prospects for the use of magnesium in biomedical applications.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Article
Chemistry, Physical
Qiquan Li, Xiaolong Ma, Chengyang Xiong, Wentao Qu, Yan Li
Summary: The effects of annealing temperature on the microstructures, mechanical properties and shape memory effect of Ti-19Zr-11Nb-2Ta alloy sheets have been investigated. The results show that the annealing temperature significantly affects the thickness of martensite variants, elongation, and plasticity of the alloy.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Qiquan Li, Xiaolong Ma, Xiaoyun Song, Chengyang Xiong, Wentao Qu, Yan Li
Summary: The superelastic behavior of Ti-19Zr-11Nb-4Ta shape memory alloy is influenced by aging treatments, where increasing aging temperature suppresses the formation of martensite.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Chemistry, Multidisciplinary
Tonghui Wang, Jinbo Fei, Zhenzhen Dong, Xia Xu, Weiguang Dong, Junbai Li
Summary: In this study, a synthetic electrozyme was coupled with a supramolecule-assembled nanoarchitecture to mimic mitochondrial oxidative phosphorylation and achieve enhanced bioenergy transformation. The metal-free electrozyme, a semiconducting polymer deposited on an electrode, exhibited a well-matched electrocatalytic property that allowed the oxidation of reduced nicotinamide adenine dinucleotide (NADH) to release protons at a much lower electric potential. As a result, a proton gradient was generated and drove the rotary catalysis of adenosine 5'-triphosphate (ATP) synthase in a lipid membrane, resulting in the production of ATP. Significantly, the electrochemical bioenergy conversion of NADH to ATP in this bio-like system was much more efficient compared to natural mitochondria. This work integrates synthetic and natural catalytic chemistry, facilitating enhanced bioenergy transformation and greatly improving prospects in ATP-fueled bioapplications.
Article
Materials Science, Multidisciplinary
Donglei He, Hao Gong, Ziyue Zhang, Yang Zheng, Hu Zhang, Yan Li
Summary: The in-vitro corrosion behaviors of extruded Mg-xGa (x = 1, 3, 5) alloys in alpha minimum essential medium (alpha-MEM) were investigated. The bilayer corrosion film was composed of an outer layer dominated by amorphous phosphates-carbonates and an inner layer dominated by MgO-Mg(OH)(2). Pure Mg and Mg-1Ga exhibited low corrosion rates and homogeneous corrosion behaviors owing to the protection from the compact corrosion films. By contrast, Mg-3Ga and Mg-5Ga exhibited high corrosion rates and inhomogeneous corrosion behaviors owing to the bulky micro-galvanic corrosion caused by Mg5Ga2. Based on these results, possible corrosion models were developed.
Article
Nanoscience & Nanotechnology
Ziyue Zhang, Donglei He, Yang Zheng, Yan Wu, Qiquan Li, Hao Gong, Xiaolong Ma, Yan Li
Summary: This study investigated the effects of Ga content on the microstructure and mechanical properties of hot-extruded Mg-2Zn-xGa alloys. The results showed that increasing Ga content refined the grains and increased the amount of Mg5Ga2 precipitates, leading to enhanced strength properties. However, excessive Mg5Ga2 precipitates resulted in reduced elongation.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Donglei He, Hao Gong, Ziyue Zhang, Yang Zheng, Hu Zhang, Yan Li
Summary: This study examined the microstructures and mechanical properties of a hot-extruded Mg-5Ga alloy after ageing treatment. The results showed that particle-shaped and rod-shaped Mg5Ga2 precipitates were formed in the alloy after peak ageing treatment, leading to significant improvements in yield strength and ultimate tensile strength. These improvements were mainly attributed to the enhanced precipitation strengthening by newly formed fine Mg5Ga2 precipitates. However, high-temperature ageing treatment resulted in coarsening of Mg5Ga2 particles, leading to a decrease in ductility of the alloy.
PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Zhenzhen Dong, Jinbo Fei, Tonghui Wang, Junbai Li
Summary: A strategy of matched spectral and temporal light management is developed to improve photosynthetic efficiency by co-assembling natural thylakoid membrane (TM) with artificial long afterglow particle (LAP). LAP with excellent stability and biocompatibility is optically-matched with the absorption of TM, serving as an additional light source for photosynthesis. Enhanced photosynthesis is achieved after co-assembly, with boosted electron transfer, oxygen yield, and ATP production due to down-conversion fluorescence emission from LAP. This proof-of-concept work opens a new route to augment the photosynthetic efficiency of green plants by utilizing precise light-managed materials.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Gao Jingru, He Donglei, Guo Jiale, Xue Xianda, Bi Yanze, Li Yan, Zheng Yang, Yu Hongyan
Summary: This study investigates the microstructures, mechanical properties, biodegradation behavior, and cytocompatibility of as-cast Mg-2Ga and Mg-5Ga alloys. The addition of Ga refines the grain size and enhances the mechanical properties of the alloys. It also improves the corrosion behavior of the alloys. Both Mg-2Ga and Mg-5Ga alloys show favorable cytocompatibility with no cytotoxicity for L929 cells.
RARE METAL MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Yan Wu, Zichao Deng, Xueying Wang, Aihua Chen, Yan Li
Summary: In this study, a bowl-shaped nanostructure coating with photocatalytic and photothermal synergistic antibacterial properties was prepared using self-assembled microspheres as templates. The coating can reduce implant-related infections and promote osteoblast growth and adhesion.
REGENERATIVE BIOMATERIALS
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)