Article
Chemistry, Applied
Ying Wan, Jian Li, Jitong Ma, Yanan Li, Ren Wang, Zhengxing Chen, Tao Wang
Summary: In this study, co-assembled protein-polysaccharide complexes (ZCs) were prepared by fixing zein nanoparticles at the fibrillar carboxymethyl cellulose (CMC) by pH-driven anti-solvent precipitation. The complexation boosted the dispersity of zein from 17.3% to 88.6%. Scanning electron microscopy and atomic force microscopy confirmed the formation of network structures where the fibrous polysaccharides inserted into the interval of granular proteins. Circular dichroism spectrum, fluorescence spectrum, and X-ray diffraction verified the electrostatic interaction pattern between zein and CMC. Besides, the ZCs presented favorable amphiphilic properties, and the electrostatic interaction between zein and CMC can be fine-tuned by the substitution degree (DS) of carboxymethyl in CMC. Therefore, the Pickering emulsions stabilized by ZCs had controllable size and long-term stability using DS as a stimulus. Our study offers a novel strategy developing bio-based materials as novel stabilizers of Pickering emulsions.
Article
Biochemistry & Molecular Biology
Congnan Cen, Feifei Wang, Yifan Wang, Huan Li, Linglin Fu, Yan Li, Jian Chen, Yanbo Wang
Summary: A novel composite film for food packaging was prepared using hydroxyethyl cellulose (HEC), carboxymethyl chitosan (CMCS), and zinc oxide nanoparticles by solution casting method. Spectroscopy, crystallography, and morphology observation confirmed the successful incorporation of nanoparticles. The addition of CMCS and ZnO improved the solvent resistance (reduced water solubility by 94.3%) and UV shielding ability (increased UV shielding capacity by 45.73%) of the film, enhancing its potential applications in water-rich foods. The composite film demonstrated efficient inhibition (>99.99% inhibition rate) of pathogenic bacteria Listeria monocytogenes and Pseudomonas aeruginosa, with the synergistic effect of CMCS and ZnO. Furthermore, CMCS and ZnO significantly enhanced the elasticity (494.34% improvement) and maximum load capacity (142.24% improvement) of the composite film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Zhongyu Yang, David Julian McClements, Xinwen Peng, Zhenlin Xu, Man Meng, Long Chen, Zhengyu Jin
Summary: Composite nanoparticles composed of zein and carboxymethyl cellulose were prepared for the co-delivery of resveratrol and quercetin. These nanoparticles exhibited good thermal stability and improved antioxidant activities when encapsulating both bioactive compounds.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Applied
Qin Liu, Yaochang Li, You Zhou, Lei Jiang, Qingyun Lyu, Gang Liu, Xuedong Wang, Xi Chen, Lei Chen
Summary: This study successfully prepared apigenin-loaded zein composite nanoparticles using a pH-driven self-assembly method. The composite nanoparticles, stabilized by whey protein isolate and carboxymethyl cellulose, exhibited high potential, small size, and uniform particle size distribution. The nanoparticles showed conformational changes during the neutralization process, driven by hydrophobic interaction and hydrogen bonding.
Article
Engineering, Environmental
Chenyuan Zhang, Xianpeng Yang, Shuang Yang, Zhongqi Liu, Lei Wang
Summary: Improving pesticide utilization efficiency and reducing environmental pollution caused by rain washing can be achieved by modifying natural lignocellulosic nanofibres and using them as additives. The surface-modified nanofibres enhance droplet deposition and retention, leading to a more sustainable agricultural system.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Ceramics
Ramasubba Reddy Palem, Sivalingam Ramesh, Chinna Bathula, Vijay Kakani, Ganesh D. Saratale, Hemraj M. Yadav, Joo-Hyung Kim, Heung Soo Kim, Soo-Hong Lee
Summary: In this study, a composite material of CMC and CuO@MnO2 was synthesized using a thermal reduction method, showing unique morphology and excellent electrochemical properties with high specific capacitance and cycling stability.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Shumin Wang, Yingxuan Xie, Huanhuan Su, Yanran Luo, Mengting Wang, Teng Li, Yuying Fu
Summary: Curcumin solid dispersions (Cur SDs) were prepared using hydroxypropyl methyl cellulose (HPMC) and sodium carboxymethyl cellulose (CMC) at different dosages. The addition of CMC enhanced the characteristic peak shift of curcumin, reduced contact angle, increased surface free energy, and improved the solubility of Cur SDs. The morphology of Cur SDs changed from needle-like to sheet-like with the addition of CMC. The addition of CMC significantly improved the anti-proliferation effect of Cur SDs, enhancing the bioavailability of curcumin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Paper & Wood
Yanan Wang, Hanyu Zhao, Lijie Huang, Guangxue Chen, Zhehao Wei, Qi Mo, Yishan Li, Xiyue Wang, Chongxing Huang, Qifeng Chen
Summary: In this study, a sustained-release gel for chlorine dioxide (ClO2) gas was developed using degradable materials such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and beta-cyclodextrin (beta CD) through a simple and benign crosslinking strategy. The gel showed sustained-release property within a wide temperature range and released ClO2 gas effectively for more than 30 days. A new diffusion model based on the Korsmeyer-Peppas model was proposed and achieved an excellent fit. This sustained-release gel provides guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained-release model of skeleton-soluble hydrogels.
Article
Engineering, Environmental
Meisam Sadeghi, Zahra Moghimifar, Hamedreza Javadian, Mohsen Jahanshahi, Majid Farsadrooh
Summary: In this study, spherical CMC-C-Ni composite beads were synthesized as an adsorbent for the treatment of oily wastewater from rapeseed industry. The beads exhibited a porous structure and stable physical characteristics. Results showed that increasing fluid viscosity led to a reduction in terminal settling velocity.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Yue Wang, Kei Kanie, Toshiaki Takezawa, Miki Horikawa, Kyoshiro Kaneko, Ayako Sugimoto, Aika Yamawaki-Ogata, Yuji Narita, Ryuji Kato
Summary: During wound regeneration, a membrane with dual surfaces, combining the properties of carboxymethyl cellulose (CMC) and collagen, was developed using vitrification. This membrane provides strong cell adhesion-inhibition and cell adhesion simultaneously.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Kyeong-Jung Kim, Min-Jin Hwang, Wang-Geun Shim, Young -Nam Youn, Soon Do Yoon
Summary: The study synthesized CTP-incorporated biomaterials for antihypertensive therapy and found that these materials have excellent drug release capacity and significant inhibition effect on cardiovascular disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Food Science & Technology
Liping Zhou, Yi Wang
Summary: This study developed zein-MC composite films with improved mechanical properties, elongation, and antimicrobial activity, while reducing water vapor permeability and solubility of the films. Incorporating thymol into the composite films effectively inhibited the growth of E. coli and S. aureus at specific concentrations.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Qunhao Wang, Mei Li, Zhuo Zheng, Yan Niu, Xiaolin Xue, Chenghong Ao, Wei Zhang, Canhui Lu
Summary: In this study, a novel wound dressing with high drug loading capacity and sustained drug release properties was successfully fabricated by electropinning of cellulose followed by polyethylenimine (PEI)-functionalization. The grafted PEI chains on the surface of electrospun cellulose nanofibers provided numerous active amino groups, leading to enhanced adsorption performance against the anionic drug of sodium salicylate (NaSA). The NaSA-loaded cellulose-PEI could continuously release the drug for 12 hours in simulated body fluid (SBF), demonstrating the versatility of cellulose-PEI as an advanced wound dressing with drug carrier functionalities.
Article
Nanoscience & Nanotechnology
Jeong Man An, S. M. Shatil Shahriar, Mohammad Nazmul Hasan, Sungpil Cho, Yong-Kyu Lee
Summary: This study developed biocompatible and biodegradable antiadhesion agents with excellent physical characteristics and stability, showing high effectiveness in preventing postlaparotomy adhesion; in SD rat experiments, they were more effective than the traditional Medicurtain, demonstrating great potential in reducing complications during clinical surgeries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Hossein Alizadeh, Malihe Pooresmaeil, Hassan Namazi
Summary: In recent years, the fabrication of new drug delivery systems (DDSs) based on functionalization by multi-component reactions (MCRs) has received special attention. The CMC@MWCNTs@FCA carrier was designed and prepared from the functionalization of the CMC@MWCNTs as a biocompatible raw material with carboxamide group by the Ugi reaction. The obtained findings indicate that the fabricated system can be proposed as a biocompatible carrier for specific colon cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)