Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis

Why is Pancreatic Cancer so Deadly? The Pathologist's View

(2019) Ralph H. Hruban et al.   JOURNAL OF PATHOLOGY

Characterization of spatial distribution of tumor-infiltrating CD8+ T cells refines their prognostic utility for pancreatic cancer survival

(2019) Yohei Masugi et al.   MODERN PATHOLOGY

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

(2018) Tatsuo Hata et al.   AMERICAN JOURNAL OF PATHOLOGY

KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study

(2018) Yutaka Nakano et al.   BRITISH JOURNAL OF CANCER

Risk of multiple pancreatic cancers in CDKN2A-p16-Leiden mutation carriers

(2018) Isaura Ibrahim et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

(2018) Andrew J Aguirre et al.   Cancer Discovery

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma

(2018) Zhi Rong Qian et al.   JAMA Oncology

Precancerous neoplastic cells can move through the pancreatic ductal system

(2018) Alvin P. Makohon-Moore et al.   NATURE

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma

(2018) Takafumi Nakagaki et al.   TUMOR BIOLOGY

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer

(2018) Daisuke Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY

Pancreatic cancer arising in the remnant pancreas is not always a relapse of the preceding primary

(2018) Claudio Luchini et al.   MODERN PATHOLOGY

A genetic roadmap of pancreatic cancer: still evolving

(2017) Faiyaz Notta et al.   GUT

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

(2017) Waki Hosoda et al.   JOURNAL OF PATHOLOGY

The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia

(2017) Yoko Matsuda et al.   PANCREAS

Soils and Seeds That Initiate Pancreatic Cancer Metastasis

(2017) Christopher R. Vakoc et al.   Cancer Discovery

Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing

(2017) Takafumi Nakagaki et al.   Oncotarget

KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer

(2017) Jonas Cicenas et al.   Cancers

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

(2016) Yusuke Fujita et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Serrated neoplasia—role in colorectal carcinogenesis and clinical implications

(2015) Joep E. G. IJspeert et al.   Nature Reviews Gastroenterology & Hepatology

Upregulated SMAD3 promotes epithelial–mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma

(2014) Ken Yamazaki et al.   LABORATORY INVESTIGATION

Pancreatic Intraglandular Metastasis Predicts Poorer Outcome in Postoperative Patients With Pancreatic Ductal Carcinoma

(2013) Seiji Oguro et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PanIN-Specific Regulation of Wnt Signaling by HIF2  during Early Pancreatic Tumorigenesis

(2013) A. Criscimanna et al.   CANCER RESEARCH

Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics

(2012) Y Kanda   BONE MARROW TRANSPLANTATION

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

(2011) Toru Furukawa et al.   Scientific Reports

Molecular Diagnosis of Multistage Hepatocarcinogenesis

(2010) M. Sakamoto et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE