Article
Immunology
Fu-xue Huang, Jun-wan Wu, Xia-qin Cheng, Jiu-hong Wang, Xi-zhi Wen, Jing-jing Li, Qiong Zhang, Hang Jiang, Qiu-yue Ding, Xiao-feng Zhu, Xiao-shi Zhang, Ya Ding, Dan-dan Li
Summary: This study showed that high expression of HHLA2 is associated with better prognosis and improved response to immune checkpoint blockades in melanoma patients. The expression of HHLA2 is also positively correlated with the density of CD8(+) tumor infiltrating lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nian Liu, Mingjie Yan, Qian Tao, Jie Wu, Jing Chen, Xiang Chen, Cong Peng
Summary: The study identified significant metabolic alterations in glycolysis and the TCA cycle in melanoma patients and demonstrated the negative correlation between PDHA1, OGDH, and the efficacy of anti-PD-1 immunotherapy. Inhibiting PDHA1 and OGDH improved melanoma progression and therapeutic efficacy of anti-PD-1 treatment. Suppression of the TCA cycle led to increased PD-L1 expression and glycolysis flux, providing a potential novel strategy for melanoma treatment with anti-PD-1 immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Cathrine Lund Lorentzen, Julie Westerlin Kjeldsen, Eva Ehrnrooth, Mads Hald Andersen, Inge Marie Svane
Summary: Summary: This study presented the long-term follow-up results of the IDO/PD-L1 vaccine and nivolumab combination therapy in cohort A, showing promising efficacy with high overall response rates and durable responses. However, cohort B did not show significant clinical effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Huiyu Yan, Aimin Jiang, Yinong Huang, Jun Zhang, Wenguang Yang, Wei Zhang, Tianya Liu
Summary: Exercise can function as a hypoxia modulator to improve the tumor immune microenvironment, thereby promoting anti-tumor efficacy and facilitating biologically safe sensitization of PD-1/PD-L1 immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Myong Hak Ri, Juan Ma, Xuejun Jin
Summary: This study reviews the pharmacological effects of natural products, raw extracts, and traditional medicines associated with the PD-1/PD-L1 axis in cancer immunotherapy, particularly focusing on PD-L1. It was found that several natural products and traditional medicines have diverse and multi-functional effects that can improve strategies for anti-PD-1/PD-L1 therapy, but further research and exploration are needed.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Hikmat H. Assi, Chihunt Wong, Kimberly A. Tipton, Li Mei, Ken Wong, Jennifer Razo, Chanty Chan, Bruce Howng, Jason Sagert, Michael Krimm, Linnea Diep, Andrew Jang, Margaret T. Nguyen, Nicole Lapuyade, Victoria Singson, Ruth Villanueva, Madan Paidhungat, Shouchun Liu, Vangipuram Rangan, Olga Vasiljeva, James W. West, Jennifer H. Richardson, Bryan Irving, Dylan Daniel, Marcia Belvin, W. Michael Kavanaugh
Summary: Using protease-activatable antibody prodrugs (Pb-Tx) to locally inhibit PD-1/PD-L1 can reduce systemic immune toxicity while eliciting potent anti-tumor immune responses.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Daniel J. Olson, Zeynep Eroglu, Bruce Brockstein, Andrew S. Poklepovic, Madhuri Bajaj, Sunil Babu, Sigrun Hallmeyer, Mario Velasco, Jose Lutzky, Emily Higgs, Riyue Bao, Timothy C. Carll, Brian Labadie, Thomas Krausz, Yuanyuan Zha, Theodore Karrison, Vernon K. Sondak, Thomas F. Gajewski, Nikhil Khushalani, Jason J. Luke
Summary: This study is the first prospective study in melanoma of pembrolizumab plus low-dose ipilimumab after anti-PD-1/L1 immunotherapy failure, demonstrating significant antitumor activity and tolerability.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Immunology
Jie Mei, Yun Cai, Huiyu Wang, Rui Xu, Jiaofeng Zhou, Jiahui Lu, Xuejing Yang, Jiadong Pan, Chaoying Liu, Junying Xu, Yichao Zhu
Summary: This study aims to explore the expressions, prognostic values, and immunological correlations of Formins in cancer. DIAPH1 functioned as an oncogene in breast cancer and mediated epithelial-mesenchymal transformation (EMT) and PD-L1 expression. Moreover, DIAPH1 was overexpressed in most cancers and functioned as a novel pan-cancer immuno-marker, which could predict the response to anti-PD-1/PD-L1 immunotherapy.
CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Mengke Niu, Ming Yi, Ning Li, Suxia Luo, Kongming Wu
Summary: Immunotherapy, particularly anti-PD-1/PD-L1 treatment, has shown significant improvements in the survival of NSCLC patients, although the overall response rate remains suboptimal. Various factors influence treatment outcomes, indicating the importance of exploring biomarkers to better select patients and predict treatment efficacy accurately.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Immunology
Andrea Botticelli, Alessio Cirillo, Lidia Strigari, Filippo Valentini, Bruna Cerbelli, Simone Scagnoli, Edoardo Cerbelli, Ilaria Grazia Zizzari, Carlo Della Rocca, Giulia D'Amati, Antonella Polimeni, Marianna Nuti, Marco Carlo Merlano, Silvia Mezi, Paolo Marchetti
Summary: This study compared the efficacy of anti-PD-1 and anti-PD-L1-based therapy in R/M HNSCC patients through a systematic review and network meta-analysis. It found no significant differences in overall survival between different subgroups, except for metastatic patients where anti-PD-1-based therapy was associated with significantly less risk of death.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Junjie Liu, Haisu Tao, Tong Yuan, Jiang Li, Jian Li, Huifang Liang, Zhiyong Huang, Erlei Zhang
Summary: Anti-PD-1/PD-L1 therapy is an effective strategy for cancer treatment, but drug resistance is a challenge. Combining this therapy with regorafenib can enhance its efficacy. Regorafenib modifies the tumor microenvironment through various mechanisms and has immunomodulatory effects on immune cells and tumor cells. Studies on the synergistic mechanism of combination therapy can improve cancer treatment and patient selection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Zhenyu Zhao, Kongming Wu
Summary: TGF-beta signaling has predictive value in cancer immunotherapy, and targeted therapies against TGF-beta are important strategies to overcome treatment resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Yu-Xiang Ge, Tai-Wei Zhang, Lei Zhou, Wang Ding, Hai-Feng Liang, Zhi-Chao Hu, Qin Chen, Jian Dong, Feng-Feng Xue, Xiao-Fan Yin, Li-Bo Jiang
Summary: pH-sensitive nano carrier CBZP enhances the immunotherapeutic response and antitumor T cell immunity by activating autophagic cell death and inhibiting PD-1/PD-L1 interaction in osteosarcoma, suggesting its potential clinical significance.
Article
Multidisciplinary Sciences
Changsheng Huang, Shengxiang Ren, Yaqi Chen, Anyi Liu, Qi Wu, Tao Jiang, Panjing Lv, Da Song, Fuqing Hu, Jingqing Lan, Li Sun, Xue Zheng, Xuelai Luo, Qian Chu, Keyi Jia, Yan Li, Jun Wang, Caicun Zou, Junbo Hu, Guihua Wang
Summary: This research discovered that PD-L1 K162 was methylated by SETD7 and demethylated by LSD2. Additionally, PD-L1 K162 methylation controlled the PD1/PD-L1 interaction and significantly enhanced the suppression of T cell activity in controlling cancer immune surveillance. The study demonstrated that PD-L1 hypermethylation was the key mechanism for anti-PD-L1 therapy resistance, identified PD-L1 K162 methylation as a negative predictive marker for anti-PD-1 treatment in patients with non-small cell lung cancer, and showed that the PD-L1 K162 methylation:PD-L1 ratio was a more accurate biomarker for predicting anti-PD-(L)1 therapy sensitivity.
Article
Pharmacology & Pharmacy
Yihang Qi, Lin Zhang, Zhongzhao Wang, Xiangyi Kong, Jie Zhai, Yi Fang, Jing Wang
Summary: Anti-PD-1/PD-L1 monotherapy showed manageable safety profile and promising and durable anti-tumor efficacy in metastatic breast cancer patients. Higher PD-L1 expression may be closely correlated to better clinical efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Wei Wang, Fengju Song, Xiangling Feng, Xinlei Chu, Hongji Dai, Jing Tian, Xuan Fang, Fangfang Song, Ben Liu, Lian Li, Xiangchun Li, Yanrui Zhao, Hong Zheng, Kexin Chen
Summary: This study identified 162 target genes enriched in cancer-related pathways through combinatorial analysis of high-resolution contact maps and fine-mapped credible variants from EOC GWAS, with 132 HiChIP targets being identified for EOC causal variants for the first time. More than half of the credible variants were found to be involved in interactions over 185 kb in distance, indicating the importance of long-range transcriptional regulation in the function of GWAS variants in EOC. Additionally, many HiChIP gene targets showed significant differential expressions between normal ovarian and EOC tumor samples, with one target validated through CRISPR-Cas9 deletion experiments.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Xin Hu, Liuxing Wu, Ben Liu, Kexin Chen
Summary: This study investigated the immune infiltration status and prognostic value of immune-related lncRNAs in AEG. They identified two immune infiltration subtypes, selected six prognosis-related lncRNAs, and constructed an immune risk signature. The results showed that the immune-related risk signature could be an independent prognostic factor in AEG patients and predict the response to immunotherapy and chemotherapy effectively.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Lian-Jing Cao, Xiao-Lin Peng, Wen-Qiong Xue, Rong Zhang, Jiang-Bo Zhang, Ting Zhou, Zi-Yi Wu, Gai-Rui Li, Tong-Min Wang, Yong-Qiao He, Da-Wei Yang, Ying Liao, Xia-Ting Tong, Fang Wang, Ke-Xin Chen, Shi-Hong Zhang, Li-Qing Zhu, Pei-Rong Ding, Wei-Hua Jia
Summary: This study identified biomarkers for CRC and AA detection, and developed a prediction score for distinguishing AA and CRC from healthy subjects with high sensitivity and specificity. The noninvasive approach showed promising results in both validation and screening cohorts, indicating its potential for wide application in diagnostic and screening tests.
Article
Biochemical Research Methods
Hongru Shen, Xilin Shen, Mengyao Feng, Dan Wu, Chao Zhang, Yichen Yang, Meng Yang, Jiani Hu, Jilei Liu, Wei Wang, Yang Li, Qiang Zhang, Jilong Yang, Kexin Chen, Xiangchun Li
Summary: The study introduces a universal approach called iSEEEK for integrating super large-scale single-cell expression data, demonstrating good clustering performance and the ability to transfer knowledge to new datasets, enabling the identification of gene-gene interaction networks characteristic of specific cell types.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanju Li, Yihui Du, Yubei Huang, Yingru Zhao, Grigory Sidorenkov, Marleen Vonder, Xiaonan Cui, Shuxuan Fan, Monique D. Dorrius, Rozemarijn Vliegenthart, Harry J. M. Groen, Shiyuan Liu, Fengju Song, Kexin Chen, Geertruida H. de Bock, Zhaoxiang Ye
Summary: The efficiency of LDCT screening for lung cancer in China was evaluated through a community-based screening study and meta-analysis. The study results suggest a potential effectiveness of LDCT screening in China, with a stage shift observed in lung cancer cases. Additionally, nearly 70% of screen-detected lung cancers in low-risk populations are found in women.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dandan Huang, Yao Zhou, Xianfu Yi, Xutong Fan, Jianhua Wang, Hongcheng Yao, Pak Chung Sham, Jihui Hao, Kexin Chen, Mulin Jun Li
Summary: VannoPortal is a comprehensive variant annotation database that integrates extensive genomic/epigenomic data and commonly used annotation databases, with rich features and visualization tools to provide comprehensive and context-specific variant annotations for biologists and clinicians.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Genetics & Heredity
Dan Wu, Mengyao Feng, Hongru Shen, Xilin Shen, Jiani Hu, Jilei Liu, Yichen Yang, Yang Li, Meng Yang, Wei Wang, Qiang Zhang, Fangfang Song, Ben Liu, Kexin Chen, Xiangchun Li
Summary: This study investigates the immune infiltration signatures of gastric cancer and their relationship with prognosis. Two distinct subtypes of gastric cancer (C1/C2) are identified, with C2 having a better prognosis than C1. The association of C1/C2 with prognosis remains significant after controlling for age, gender, and stage. The prognostic prediction of C1/C2 is validated in four independent cohorts. The study provides valuable insights into the association between immune infiltration and the prognosis of gastric cancer.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Zhen Zeng, Chunxiang Ma, Kexin Chen, Mingshan Jiang, Reshma Vasu, Rui Liu, Yinglan Zhao, Hu Zhang
Summary: Gastrointestinal cancers are common and devastating worldwide, with high mortality rates despite significant treatment advances. GPCRs play crucial roles in the development of GI cancers, driving further research into new therapeutic targets.
Article
Cell Biology
Hongji Dai, Xinlei Chu, Qian Liang, Mengyun Wang, Lian Li, Yao Zhou, Zhanye Zheng, Wei Wang, Zhao Wang, Haixin Li, Jianhua Wang, Hong Zheng, Yanrui Zhao, Luyang Liu, Hongcheng Yao, Menghan Luo, Qiong Wang, Shan Kang, Yan Li, Ke Wang, Fengju Song, Ruoxin Zhang, Xiaohua Wu, Xi Cheng, Wei Zhang, Qingyi Wei, Mulin Jun Li, Kexin Chen
Summary: Survival rates for ovarian cancer patients can vary significantly, with a study in 2130 Chinese patients identifying a new genetic locus associated with overall survival. Through further analysis, researchers pinpointed a potentially causal SNP and a lncRNA that may regulate tumor growth.
Article
Oncology
Xilin Shen, Xiaoli Wang, Hongru Shen, Mengyao Feng, Dan Wu, Yichen Yang, Yang Li, Meng Yang, Wei Ji, Wei Wang, Qiang Zhang, Fangfang Song, Ben Liu, Kexin Chen, Xiangchun Li
Summary: This study utilized a deep learning model to stratify brain tumors and identified two distinctive subtypes (C1/2) with different immune infiltration signatures. The C1 subtype showed protective immune infiltration characteristics and better prognosis compared to the C2 subtype, which had more immune suppressive and angiogenic signatures. These findings suggest that immune infiltration signatures could serve as an independent prognostic factor for brain tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Liuxing Wu, Xin Hu, Hongji Dai, Kexin Chen, Ben Liu
Summary: In this study, a risk signature related to m6A in melanoma was developed, consisting of 12 genes. The low-risk group showed a favorable prognosis, higher expression of immune checkpoints, and immune cell infiltration, making them potential beneficiaries of immune checkpoint blockade therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Qiang Zhang, Sheng Zhang, Yi Pan, Lin Sun, Jianxin Li, Yu Qiao, Jing Zhao, Xiaoqing Wang, Yixing Feng, Yanhui Zhao, Zhiming Zheng, Xiangming Yang, Lixia Liu, Chunxin Qin, Ke Zhao, Xiaonan Liu, Caixia Li, Liuyang Zhang, Chunrui Yang, Na Zhuo, Hong Zhang, Jie Liu, Jinglei Gao, Xiaoling Di, Fanbo Meng, Linlei Zhang, Yuxuan Wang, Yuansheng Duan, Hongru Shen, Yang Li, Meng Yang, Yichen Yang, Xiaojie Xin, Xi Wei, Xuan Zhou, Rui Jin, Lun Zhang, Xudong Wang, Fengju Song, Xiangqian Zheng, Ming Gao, Kexin Chen, Xiangchun Li
Summary: The authors develop a deep learning model for the diagnosis of Hashimoto's thyroiditis and test its performance on a large dataset. The model exceeds the performance of radiologists in terms of accuracy and sensitivity and shows improved performance when integrating serologic markers with imaging data.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Xi Zhang, Ben Liu, Henry S. Lynn, Kexin Chen, Hongji Dai
Summary: This study examines the association between poor oral health and the risk of developing or dying of cancer, and finds that poor oral health is associated with an increased risk of total cancer incidence, particularly digestive system cancers. The association is stronger among rural residents.
Letter
Biochemistry & Molecular Biology
Yao Zhou, Xinyi Qian, Zipeng Liu, Hongxi Yang, Tong Liu, Kexin Chen, Yaogang Wang, Pak Chung Sham, Ying Yu, Mulin Jun Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Liwen Zhang, Lu Han, Yubei Huang, Ziwei Feng, Xin Wang, Haixin Li, Fangfang Song, Luyang Liu, Junxian Li, Hong Zheng, Peishan Wang, Fengju Song, Kexin Chen
Summary: The study revealed an association between SNPs within microRNA binding sites and breast cancer prognosis, with the LRRK2 rs10878441 CC genotype being specifically linked to poor prognosis. This genotype may serve as a potential prognostic biomarker for breast cancer. Stratified analyses demonstrated the relevance of rs10878441 in grade II patients and lymph node-negative patients in terms of breast cancer prognosis.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.