Article
Medicine, Research & Experimental
Hongtao He, Muliang Ding, Tao Li, Wenzhi Zhao, Lu Zhang, Peng Yin, Wei Zhang
Summary: This study discovers that NORAD, a non-coding RNA highly expressed in osteosarcoma cells, can be delivered to osteosarcoma cells through extracellular vesicles (EVs) released by bone mesenchymal stem cells (BMSCs), thereby promoting proliferation and invasion of osteosarcoma. NORAD is found to interact with miR-30c-5p and KLF10, and regulates the miR-30c-5p/KLF10 axis to influence the development and metastasis of osteosarcoma.
LABORATORY INVESTIGATION
(2022)
Article
Cell Biology
Wenjie Luo, Jun Wang, Wenhao Xu, Chunguang Ma, Fangning Wan, Yongqiang Huang, Mengfei Yao, Hailiang Zhang, Yuanyuan Qu, Dingwei Ye, Yiping Zhu
Summary: The lncRNA RP11-89 promotes cell proliferation, migration, tumorigenesis and inhibits cell cycle arrest through the miR-129-5p/PROM2 axis in bladder cancer. RP11-89 acts as a sponge for miR-129-5p, upregulating PROM2 and activating iron export, leading to attenuation of ferroptosis. RP11-89 is a novel tumorigenic regulator that may serve as a potential biomarker for targeted therapy in bladder cancer.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Shuhong Dai, Ning Li, Ming Zhou, Yue Yuan, Ding Yue, Tao Li, Xiaowei Zhang
Summary: The study investigated the role of EBLN3P in osteosarcoma progression by modulating the miR-224-5p/Rab10 pathway, leading to enhanced cell proliferation, migration, and invasion. This finding suggests a potential new approach to diagnosing and treating osteosarcoma.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Li Zhang, Xiufen Chen, Mingxiu Chang, Boning Jiao
Summary: The study revealed that miR-30c-5p plays a role in Parkinson's disease by modulating apoptosis and autophagy. AntagomiR of miR-30c-5p partially reversed the abnormalities associated with PD in mice, suggesting a potential therapeutic effect.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Oncology
Huangkai Zhu, Xiang Xu, Enkuo Zheng, Junjun Ni, Xu Jiang, Minglei Yang, Guofang Zhao
Summary: This study aimed to elucidate the molecular mechanism of lncRNA RP11-805J14.5 in LUAD development. The study found that RP11-805J14.5 was highly expressed in LUAD tissues and cells and was associated with poor prognosis in LUAD patients. Knockdown of RP11-805J14.5 suppressed LUAD cell growth, invasion, migration, and tumor growth, indicating that RP11-805J14.5 is an important regulator in LUAD.
Article
Cell Biology
Chang-Jun Tong, Qing-Chun Deng, Di-Jun Ou, Xia Long, He Liu, Kang Huang
Summary: The upregulation of lncRNA RUSC1-AS1 in osteosarcoma promotes cell proliferation, invasion, and inhibits apoptosis, as well as enhances the epithelial-mesenchymal transition (EMT) process. Inhibition of RUSC1-AS1 also showed suppressive effects on tumor growth in vivo, indicating its potential as a therapeutic target for osteosarcoma.
Article
Oncology
Zhen Wang, Yanting Wei, Hao Zhu, Lingfeng Yu, Jie Zhu, Qixiu Han, Ziying Liu, Jianhao Huang, Yan Zhu, Gentao Fan, Qikai Tang, Ji Qian, Xi Chen, Guangxin Zhou
Summary: The study confirms that lncRNA NDRG1 is up-regulated in osteosarcoma and promotes its proliferation and metastasis by sequestering miR-96-5p. These findings suggest that lncRNA NDRG1 may serve as a prognostic marker and therapeutic target for osteosarcoma.
Article
Environmental Sciences
Guanghui Wang, Xiyuan Wei, Shan Gao, Wenheng Chen, Yang Geng, Jia Liu, Hongya Guan
Summary: Circ_LRP6 plays a role in the occurrence and development of osteosarcoma by affecting the proliferation, migration, and invasion of osteosarcoma cells. It interacts with miR-122-5p and miR-204-5p and modulates their target gene HMGB1. The downregulation of miR-122-5p and miR-204-5p and the overexpression of HMGB1 partially restore and weaken the inhibitory effect of circ_LRP6 on osteosarcoma progression.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Ye Wang, Bin Zhou, Liping Yan, Jianhui Wu, Zhijie Xing, Shaochun Zhang, Fusheng Xiang
Summary: The study indicated that the NORAD/miR-155-5p axis plays a crucial role in regulating the proliferation, migration, and invasion of osteosarcoma cells. There is a negative correlation between NORAD and miR-155-5p expression levels in osteosarcoma samples, suggesting their potential as novel therapeutic targets for osteosarcoma management.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pathology
Hongqing Li, Qing Zhao, Zhonghao Tang
Summary: The RP11-116G8.5 lncRNA is highly expressed in LUSC cell lines and promotes malignant behaviors by sponging miR-3150b-3p and miR-6870-5p to upregulate PHF12/FOXP4 expression.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Youting Dang, Yunping Zhou, Xuehai Ou, Qiang Wang, Dengke Wei, Fei Xie
Summary: In this study, lncRNA AC007207.2 was found to be over-expressed in osteosarcoma (OS) tissues and cell lines, leading to a worse prognosis. It was also discovered that AC007207.2 promotes proliferation and metastasis of OS cells through the miR-1306-5p/SIRT7 axis, while miR-1306-5p can inhibit the malignant behavior of OS cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Medicine, Research & Experimental
Zheng He, Meng Tian, Xuan Fu
Summary: miR-30c-5p downregulation in hepatocellular carcinoma is significantly associated with patient survival and tumor size, affecting cell proliferation and migration, with RAB32 identified as a crucial target. These findings highlight the important role of miR-30c-5p in HCC growth and invasion through the miR-30c-5p-RAB32 axis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Thi An Vu, Ingrid Lema, Imene Hani, Lydie Cheval, Laura Atger-Lallier, Vilayvane Souvannarath, Julie Perrot, Melanie Souvanheuane, Yannick Marie, Sylvie Fabrega, Anne Blanchard, Jerome Bouligand, Peter Kamenicky, Gilles Crambert, Laetitia Martinerie, Marc Lombes, Say Viengchareun
Summary: Under hypertonicity, miR-324-5p and miR-30c-2-3p are recruited to regulate MR expression and signaling, affecting renal function and sodium retention.
Article
Biochemistry & Molecular Biology
Xia Bian, Yun-Ming Sun, Li-Min Wang, Ying-Lie Shang
Summary: The study identified that high expression of LINC02381 in osteosarcoma was associated with advanced clinical progress and poor clinical outcome. LINC02381 could down-regulate CDCA4 by sponging miR-503-5p, participating in regulating the proliferation, migration, and invasion of osteosarcoma cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Rui Hu, Rui Bi, Lianyong Jiang, Haibo Xiao, Xiao Xie, Hongtao Liu, Fengqing Hu
Summary: The study discovered that the overexpression of lncRNA RP11-465B22.8 in EC is associated with poor survival in patients, by sponging miR-765 to increase the expression of KLK4, promoting proliferation, migration, and invasion of EC cells, and being transferred from EC cells to macrophages via exosomes to induce cell migration and invasion.
CELL DEATH DISCOVERY
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.