Article
Immunology
Siyuan Xiong, Xuyang Su, Yingjie Kang, Junqiang Si, Lu Wang, Xinzhi Li, Ketao Ma
Summary: The study found that chlorogenic acid has anti-inflammatory effects and immunomodulatory activity. It has the potential to treat neuroinflammation. By modulating key targets in the TNF signaling pathway, chlorogenic acid can inhibit microglial polarization towards the M1 phenotype and improve neuroinflammation-induced cognitive dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Tianqi Li, Huan Wang, Siyu Dong, Meng Liang, Jun Ma, XiaoWen Jiang, Wenhui Yu
Summary: In this study, the researchers investigated the effects of maslinic acid (MA) on nonalcoholic fatty liver disease (NAFLD). The results showed that MA significantly reduced liver weight, body weight and serum lipid levels, and protected against liver steatosis and injury induced by a high-fat diet. It also demonstrated that MA increased the expression of certain proteins related to autophagy and decreased the expression of proteins related to inflammation and apoptosis. This study highlights the potential of MA as a dietary supplement for the treatment and prevention of NAFLD.
Article
Pharmacology & Pharmacy
Jianan Wang, Shoufeng Zhu, Wenping Lu, Ao Li, Yuqi Zhou, Yihuan Chen, Ming Chen, Cheng Qian, Xianwen Hu, Ye Zhang, Chunxia Huang
Summary: This study found that laparotomy in aged mice caused persistent cognitive impairment and anxiety. This impairment may be associated with mitochondrial dysfunction, oxidative stress, and dysregulated autophagy. The study also found that chronic varenicline administration improved cognitive impairment in these mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Duo Yun, Yajie Wang, Yuyu Zhang, Mengzhen Jia, Tianzhi Xie, Yihang Zhao, Cong Yang, Weixuan Chen, Rui Guo, Xuebo Liu, Xiaoshuang Dai, Zhigang Liu, Tian Yuan
Summary: The findings of the study suggest that sesamol attenuates scopolamine-induced cognitive dysfunction by balancing the cholinergic system, reducing neuroinflammation, and oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Kefei Li, Xin Ran, Yiruo Zeng, Shubo Li, Guiqiu Hu, Xiaoxuan Wang, Ying Li, Zhanqing Yang, Juxiong Liu, Shoupeng Fu
Summary: Maslinic acid has protective functions against mastitis by reducing pathological lesions, regulating intestinal flora constitution, and inhibiting inflammatory response pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Hu Luo, Xiaofang Li, Runyue Fan, Yuer Ruan, Liyin Qian, Yao Shen, Zizhen Si, Longhui Li, Yu Liu
Summary: This study investigated the effect of H3 receptor blockade on METH-induced cognitive impairment and the underlying mechanism. The results showed that METH exposure led to cognitive impairment and hippocampal apoptosis in mice, as well as increased H3 receptor protein levels in HT22 cells. However, treatment with the H3 receptor antagonist THIO improved METH-induced cognitive impairment and toxicity in both mice and HT22 cells. These findings suggest that THIO has a neuroprotective effect against METH-induced cognitive impairment and cell toxicity via the raf-MEK-ERK signaling pathway.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Shunhong Mao, Jian Yu, Lei Wang, Chunhua Zhu
Summary: The study demonstrates that pleiotrophin potentiates sevoflurane anesthesia-induced cognitive dysfunction and learning deficits in mice, while small molecule inhibitors targeting RPTP beta/zeta can ameliorate this neuroinflammation.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jiangnan Wu, Yanjing Guo, Wei Li, Zihao Zhang, Xinlei Li, Qidi Zhang, Qihang Du, Xinhuan Niu, Xijiang Liu, Gongming Wang
Summary: This study found that exploratory laparotomy induced cognitive function decline in aged mice but not in young mice, accompanied by inflammatory activation of microglia in the hippocampus. Depletion of microglia using a CSF1R inhibitor protected aged mice from POCD. The downregulation of the immune checkpoint Mef2C in aged microglia contributed to microglial priming and neuroinflammation, leading to increased vulnerability to POCD in aged individuals.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Food Science & Technology
Xiaohu Liang, Xiaoqun Luo, Danping Li, Lingqiong Kong
Summary: Ruscogenin exhibits anti-inflammatory effects in various human diseases and can ameliorate cognitive dysfunction and reduce neuronal damage and neuroinflammation induced by isoflurane in aged mice. Its neuroprotective effects may be mediated through blocking of the NLRP3 pathway.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2021)
Article
Environmental Sciences
Chen Chu, Yaling Zhang, Qingping Liu, Yaxian Pan, Yujie Niu, Rong Zhang
Summary: This study aimed to investigate the neurotoxicity of polystyrene nanoplastics (PS NPs) in mice and its underlying mechanisms. The results demonstrated that exposure to PS NPs induced cognitive decline and increased levels of reactive oxygen species (ROS) and DNA damage in mice. Gene expression analysis revealed significant alterations in synaptic function-related genes upon PS NPs exposure. A competing endogenous RNA (ceRNA) network was constructed, providing insights into the molecular events associated with nanoplastic toxicity and cognitive dysfunction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Neurosciences
Zhuonan Sun, Ning Yang, Xixi Jia, Yanan Song, Dengyang Han, Xiaoxiao Wang, Jie Sun, Zhengqian Li, Zhiyi Zuo, Xiangyang Guo
Summary: Postoperative cognitive dysfunction (POCD) is a common and significant issue that affects the prognosis of patients after surgery. Neuroinflammation plays a crucial role in the pathogenesis of POCD. Despite the lack of practical pharmacological strategies for the treatment and prevention of POCD, this study found that the natural polymethoxylated flavone Nobiletin (NOB) may be a candidate for these purposes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Chen
Summary: Recent studies have demonstrated that EPO exerts neuroprotective and neurotrophic effects on neurological disorders. However, the potential benefits of EPO on diabetic cognitive impairments have not been well studied. In this research, the authors investigated the effects of EPO on diabetic mice and HT22 cells. They found that EPO treatment improved cognitive impairments, lowered blood glucose levels, and alleviated damage in both the pancreas and hippocampus. EPO also regulated the expression of various factors related to cell survival and apoptosis in HT22 cells. The findings suggest that EPO plays a protective role in diabetic cognitive impairments by modulating BDNF and PSD-95 expression via NMDA receptors.
CELLULAR SIGNALLING
(2023)
Article
Immunology
Qiang Liu, Yi-Man Sun, Hui Huang, Chen Chen, Jie Wan, Lin-Hui Ma, Yin-Ying Sun, Hui-Hui Miao, Yu-Qing Wu
Summary: This study found that SIRT3 can improve postoperative cognitive dysfunction in aged mice by suppressing hippocampal neuroinflammation, and may be a promising therapeutic and diagnostic target for POCD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Tzu-Yu Lin, Tai-Long Pan, Pei-Wen Wang, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang
Summary: Asiatic acid alleviates seizures and improves cognitive impairment in KA-treated rats by inhibiting calpain activation, increasing AKT activation, and enhancing synaptic and mitochondrial function.
Article
Neurosciences
Qun Jiang, Mingyan Guo, Zhiyi Zuo
Summary: The aim of this study was to investigate whether living with familiar observers attenuates learning and memory dysfunction in mice with surgery. The results showed that living with familiar observers reduced anxiety and dysfunction of learning and memory in young adult male mice with surgery. It also attenuated learning and memory dysfunction and neuroinflammation in old male mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Plant Sciences
Ho Jung Bae, Jihyun Kim, Se Jin Jeon, Jaehoon Kim, Nayeon Goo, Yongwoo Jeong, Kyungnam Cho, Mudan Cai, Seo Yun Jung, Kyung Ja Kwon, Jong Hoon Ryu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jaehoon Kim, Jong Min An, Yuna Jung, Na Hee Kim, Youngwoong Kim, Dokyoung Kim
Summary: A new red-emitting hybrid material based on a single-benzene-based fluorophore (SBBF) and silica was reported for the first time. This material demonstrates bright emissions at a red wavelength, high stability, bio-imaging applicability, and antibacterial effects. These hybrid materials could potentially advance the development and applications of dye-hybrid materials in various fields.
Article
Materials Science, Biomaterials
Rae Hyung Kang, Jinju Park, Jieun Kim, Tamrin Chowdhury, Ji Hyeon Oh, Jaehoon Kim, Jaeha Shin, Minji Kim, Chul-Kee Park, Sungjun Lee, Ji Yeoun Lee, Dokyoung Kim
Summary: GBM is an aggressive malignant tumor that is difficult to regulate with conventional chemotherapy due to anatomical structure specificity, low drug targeting ability, and limited penetration depth. A study prepared four types of nanoparticles based on porous silicon nanoparticles incorporating PEG, iRGD peptide, and SIWV tetra-peptide, and evaluated their deep-tumor penetration abilities in different models. The SIWV tetra-peptide significantly enhanced the penetration depth of the nanoparticles and showed higher anticancer efficacy in therapeutic formulations, promising for nanotherapeutics and peptide-conjugated drugs for GBM.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Jaehoon Kim, Dokyoung Kim
Summary: In this study, we found that HEPES is capable of disaggregating amyloid plaques associated with Alzheimer's disease. Additionally, we demonstrated its sustained-release system for up to 2 weeks through hybridization with a biocompatible polymer, Eudragit S100.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Youngwoong Kim, Jong Min An, Jaehoon Kim, Tamrin Chowdhury, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Chul-Kee Park, Joonyoung F. Joung, Sungnam Park, Dokyoung Kim
Summary: This study developed a new fluorescent diagnostic probe with high selectivity and sensitivity for monitoring homocysteine. The probe showed rapid response and could predict the formation of glioblastoma at an early stage through sensing homocysteine in blood plasma.
ANALYTICA CHIMICA ACTA
(2022)
Article
Behavioral Sciences
Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ryu
Summary: Current antipsychotics have limited effects on the cognitive deficits of schizophrenia patients. In this study, a Toll-like receptor knockout mouse was used as a schizophrenia mouse model to evaluate the effects of repetitive training as a cognitive remediation therapy. The results showed that repetitive training improved memory retrieval and reversal learning ability in the Toll-like receptor knockout mice, and activated neuronal cells in specific brain regions. This study suggests that the Toll-like receptor knockout mouse is a useful tool for studying the neurobiological mechanisms of cognitive remediation in schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Analytical
Jong Min An, Jungyo Suh, Jaehoon Kim, Youngwoong Kim, Joo Yeon Chung, Hee Seung Kim, Sung Yong Cho, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong, Dokyoung Kim
Summary: In this study, the world's first in vitro cervical cancer diagnosis technology based on a urine test was developed and its effectiveness was verified. The fluorescence-based diagnostic method showed a high true-positive ratio (74%) for cervical cancer. It has advantages of simple equipment, small sample requirement, and short diagnosis time.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Rae Hyung Kang, Youngwoong Kim, Hye Ji Um, Jaehoon Kim, Eun-Kyoung Bang, Seung Geun Yeo, Dokyoung Kim
Summary: This study developed a novel nanoformulation to enhance the efficacy of photodynamic therapy for glioblastoma, with significant targeting ability and excellent biocompatibility.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Applied
Jaehoon Kim, Jong Min An, Youngwoong Kim, Ji Hye Jin, Sung Soo Kim, Rae Hyung Kang, Dokyoung Kim
Summary: A new synovium-homing tri-peptide, DRL, was developed through peptide screening and functionalized to visualize the synovium. The TAMRA-conjugated DRL, named DRL-TAM, demonstrated remarkable visualization ability on synovial-derived cells and synovial-related organs in cell screening and in vivo fluorescence imaging studies. This study opens up new possibilities for the diagnosis and treatment of synovium-related diseases.
Article
Chemistry, Multidisciplinary
Youngwoong Kim, Jaehoon Kim, Jong Min An, Chul-Kee Park, Dokyoung Kim
Summary: Fluorescence-guided surgery (FSG) is a surgical method that uses fluorescent materials to selectively visualize tumor sites. However, commercially available fluorescent materials have shown serious adverse effects. A new nontoxic fluorescent probe called NPO-o-Pyr has been developed for real-time human glioblastoma visualization. It has high specificity and sensitivity, fast response time, and high biocompatibility. NPO-o-Pyr can overcome the limitations of current fluorescent probes and become a new substitute in FSG.
Article
Engineering, Biomedical
Jaehoon Kim, Hyeji Um, Na Hee Kim, Dokyoung Kim
Summary: Recent research has shown that using porous silicon nanoparticles as a therapeutic platform can overcome Alzheimer's disease and deliver drugs to the brain. The study found that 6-amino-2-naphthalenesulfonic acid (ANA) is an effective compound that can disaggregate amyloid plaques. By loading ANA into porous silicon nanoparticles and targeting delivery, memory impairment in an Alzheimer's disease mouse model can be improved.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Organic
Yuna Jung, Ji Hye Jin, Youngseo Kim, Ji Hyeon Oh, Heechang Moon, Huisu Jeong, Jaehoon Kim, Yoon Kyung Park, Yohan Oh, Sungnam Park, Dokyoung Kim
Summary: In this study, a new fluorescent nanoprobe BMeS-Ali is developed for the visualization of lipid droplets (LDs). BMeS-Ali shows selective staining ability, excellent biocompatibility, and can be applied to the visualization of human fingerprints.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ji Hyeon Oh, Rae Hyung Kang, Jaehoon Kim, Eun-Kyoung Bang, Dokyoung Kim
Summary: This study presents an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles, which can release an anticancer drug for up to 2 weeks in various biological environments.
Article
Materials Science, Biomaterials
Jong Min An, Youngwon Ju, Jeong Hee Kim, Hyein Lee, Yuna Jung, Jaehoon Kim, Yong Jun Kim, Joohoon Kim, Dokyoung Kim
Summary: This study reveals the tumor alleviation properties of a nanozyme consisting of amine-terminated sixth-generation polyamidoamine dendrimers encapsulated with tiny platinum nanoparticles, showing potential for application in GBM-related basic research and clinical settings. By suppressing GBM cell migration, invasion, and adhesion, the nanozyme demonstrates its ability for tumor alleviation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Organic
Jaehoon Kim, Ji Hyeon Oh, Dokyoung Kim
Summary: Fluorescence-based materials and techniques have been widely studied and applied in various fields, especially in biology and materials science. The development of organic molecule-based fluorophores has contributed to the advancement of research in this area. Recent studies have focused on single-benzene-based fluorophores (SBBFs), exploring their physicochemical properties and applications for the development of new derivatives in the field of fluorophore-related materials science.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)