Evidence for a 'window of opportunity' in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicentre cohort study

Background The anti-tumour necrosis factor (TNF)-alpha adalimumab is the only licenced biologic for moderate-to-severe hidradenitis suppurativa (HS). No predictors of response have been identified so far. Objectives To identify clinical parameters predicting response to adalimumab and confirm its efficacy/safety. Methods The data of 389 patients with HS treated with adalimumab in 21 Italian centres were reviewed. Sex, age at onset/diagnosis/baseline, body mass index, smoking, phenotype, previous treatments, concomitant antibiotics and 'therapeutic delay', defined as the time from HS onset to adalimumab initiation, were assessed. Response to adalimumab and its impact on quality of life (QoL) were evaluated using the Hidradenitis Suppurativa Clinical Response (HiSCR) and the Dermatology Life Quality Index (DLQI) or the Visual Analogue Scale for pain (VAS pain), respectively. Logistic regression analysis was performed. Results The therapeutic delay correlated to lack of response to adalimumab at week 16 [odds ratio (OR) 1 center dot 92 for therapeutic delay > 10 years; 95% confidence interval (CI) 1 center dot 28-2 center dot 89; P = 0 center dot 0016). HiSCR was achieved in 43 center dot 7% and 53 center dot 9% patients at week 16 and 52, respectively. Significant reductions in both DLQI and VAS pain were found between week 16 vs. baseline (P < 0 center dot 0001 for both) and week 52 vs. baseline (P < 0 center dot 0001 for both). Previous immunosuppressants inversely correlated to HiSCR at week 52 (OR = 1 center dot 74, 95% CI 1 center dot 04-2 center dot 91, P = 0 center dot 0342). Conclusions Inverse correlation between therapeutic delay and clinical response was found, supporting early adalimumab use and providing evidence for a 'window of opportunity' in HS treatment. Adalimumab efficacy and safety were confirmed, along with patients' QoL improvement. Immunosuppressants could negatively influence the response to adalimumab inducing a switch to non-TNF-alpha-driven pathways. What is already known about this topic? Adalimumab is an effective and safe biologic licenced for the treatment of moderate-to-severe hidradenitis suppurativa (HS) after failure of conventional treatments. There are no reliable parameters that predict the clinical response to adalimumab in this disease. What does this study add? The therapeutic delay, defined as the time from HS onset to adalimumab initiation, significantly correlated to lack of clinical response to this drug, particularly at week 16 of treatment. This study suggests that using adalimumab in the early phases of HS should be highly encouraged.

Automated summary

This study highlights the importance of early use of adalimumab in the treatment of HS, with a significant correlation between therapeutic delay and lack of clinical response at week 16. The efficacy and safety of adalimumab were confirmed, along with improvements in patients' quality of life. Previous use of immunosuppressants could negatively impact response to adalimumab.