Review
Neurosciences
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schliesser, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Guenter U. Hoeglinger, Jochen Herms
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Previous studies have identified cellular and molecular changes that occur before the appearance of Lewy bodies (LBs) in these neurons. Understanding these early pathological events may help in the development of therapeutic and diagnostic strategies for PD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Clinical Neurology
Xiao-Tong Wang, Huan Yu, Feng-Tao Liu, Can Zhang, Ya-Hui Ma, Jian Wang, Qiang Dong, Lan Tan, Han Wang, Jin-Tai Yu
Summary: The study found that sleep disorders were associated with decreased levels of CSF alpha-syn, which may be important for monitoring disease progression and preventing the spread of alpha-syn pathology.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Liza Bergkvist, Michaela E. Johnson, Gabriela Mercado, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz, Zachary Madaj, Jiyan Ma, Katelyn Becker, Yazhou Li, Patrik Brundin
Summary: Repurposing of drugs intended for type 2 diabetes treatment to address Parkinson's disease has shown potential, especially with the use of GLP-1 analogues. However, the results of these treatments can vary significantly depending on the nature of neuronal damage and the specific neuronal population being targeted.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonas Folke, Emil Bergholt, Bente Pakkenberg, Susana Aznar, Tomasz Brudek
Summary: This study investigates the autoimmune aberrancies towards alpha-synuclein in prodromal phases of multiple-system trophy and Parkinson's Disease. The results indicate impaired reactivity towards alpha-synuclein occurs before disease onset, which may result in reduced clearance and aggregation of the protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Masashi Ikuno, Hodaka Yamakado, Ikuko Amano, Yusuke Hatanaka, Norihito Uemura, Shu-ichi Matsuzawa, Ryosuke Takahashi
Summary: Metabolomic analysis of plasma from a mouse model of prodromal Parkinson's disease (p-PD) revealed abnormalities in mitochondrial beta-oxidation and dysfunction, potentially serving as early biomarkers for PD.
NEUROSCIENCE LETTERS
(2021)
Review
Clinical Neurology
Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeida, Gabriel Ginani Ferreira, Andrezza Paula Brito Silva, Pedro Renato de Paula Brandao, Wolfgang H. Oertel, Carlos H. Schenck, Raimundo Nonato Delgado Rodrigues
Summary: The flow of gene expression is a tightly controlled cell process, with microRNAs playing a crucial role in maintaining healthy cell physiology. Aberrant expressions of microRNAs are associated with Parkinson's disease pathogenesis, while REM-sleep behavior disorder may serve as a valuable phenotype for disease prediction.
Article
Clinical Neurology
Luis Concha-Marambio, Sandrina Weber, Carly M. Farris, Mohammed Dakna, Elisabeth Lang, Tamara Wicke, Yihua Ma, Maritta Starke, Jens Ebentheuer, Friederike Sixel-Doering, Maria-Lucia Muntean, Sebastian Schade, Claudia Trenkwalder, Claudio Soto, Brit Mollenhauer
Summary: The study aimed to determine the accuracy of the alpha Syn-seed amplification assay (alpha S-SAA) in a cohort with a high proportion of PD and iRBD CSF samples. The results showed that alpha S-SAA had a 98% accuracy in detecting PD-CSF at the initial diagnosis and a 93% accuracy in detecting iRBD cases. In addition, alpha S-SAA showed higher concordance with the final diagnosis compared to DAT-SPECT. Rating: 8 out of 10.
MOVEMENT DISORDERS
(2023)
Editorial Material
Clinical Neurology
Sandrina Weber, Brit Mollenhauer
Summary: Predicting the conversion from isolated REM sleep behavior disorder to Parkinson disease is crucial, and a new study suggests that detecting misfolded alpha-synuclein in cerebrospinal fluid is a good marker of conversion risk. However, the inability to predict the timeline of progression may limit its utility.
NATURE REVIEWS NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Abbie T. Rodger, Maryam A. L. Nasser, Wayne G. Carter
Summary: Currently, there are no pharmacological treatments that can completely stop or reverse the progression of Parkinson's Disease (PD). Therefore, there is a need for neuroprotective therapies. This systematic review examines the effectiveness of anti-a-synuclein (a-syn) therapies in preventing PD progression in preclinical models and human clinical trials. The review found that novel preclinical anti-a-syn therapeutics reduced a-syn aggregations and protected against dopaminergic neuronal loss. Completed clinical trials showed significant tolerability and efficacy in reducing a-syn and minimal adverse effects. Overall, this review highlights the potential of anti-a-syn therapies in both preclinical and clinical settings to reduce a-syn accumulation and potentially slow down PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Pavan A. Vaswani, James F. Morley, Danna Jennings, Andrew Siderowf, Kenneth Marek, P. A. R. S. investigators PARS investigators
Summary: This study found that persistent hyposmia on serial olfactory testing significantly increases the risk of developing clinical PD and abnormal DAT imaging, compared to hyposmia on a single test. Repeat olfactory testing may be an efficient and cost-effective strategy to improve identification of at-risk patients for early diagnosis and disease modification studies.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Neurosciences
Miriam Hojholt Terkelsen, Ida H. Klaestrup, Victor Hvingelby, Johanne Lauritsen, Nicola Pavese, Marina Romero-Ramos
Summary: This paper reviews the evidence of neuroinflammation and peripheral immune changes in Parkinson's disease, discusses their pathological roles, and considers factors associated with the immune response.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Dareia S. Roos, Martin Klein, Dorly J. H. Deeg, Richard L. Doty, Henk W. Berendse
Summary: This study aimed to determine the prevalence of known non-motor symptoms associated with an increased risk of Parkinson's disease (PD) in a late middle-aged population, as well as their association with motor function. The results showed that approximately 11% of the late middle-aged population had two or more known PD risk factors, and these subjects had significantly worse motor function.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Chemistry, Medicinal
Yeojin Bang, Juhee Lim, Hyun Jin Choi
Summary: Parkinson's disease is a progressive neurodegenerative disease with non-motor symptoms such as olfactory dysfunction and depression, impacting the quality of life before motor symptoms appear. Studies suggest a correlation between olfactory dysfunction and an increased risk of developing PD, while depression is associated with abnormal neurotransmission and adult neurogenesis.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mario Meloni, Cristina Agliardi, Franca Rosa Guerini, Francesca Lea Saibene, Anna Vera Milner, Milena Zanzottera, Elisabetta Bolognesi, Monica Puligheddu, Michela Figorilli, Jorge Navarro, Mario Clerici
Summary: REM sleep behavior disorder (RBD) is more closely related to synucleinopathies in Parkinson's Disease (PD) compared to other neurodegenerative disorders. This study explores the potential biomarkers for RBD using neural-derived extracellular vesicles (NDEVs) in serum. The findings suggest that serum concentrations of NDEVs' oligomeric a-Syn and SNARE complex components could serve as reliable biomarkers for the RBD-specific PD endophenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
A. M. Hamilton, J. T. Lambert, L. K. Parajuli, O. Vivas, D. K. Park, I. S. Stein, J. N. Jahncke, M. E. Greenberg, S. S. Margolis, K. Zito
MOLECULAR AND CELLULAR NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Shuo Chen, Adam Z. Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J. Y. Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B. Loong Teh, Angelo H. All, Iku Tsutsui-Kimura, Kenji F. Tanaka, Xiaogang Liu, Thomas J. McHugh
Article
Neurosciences
Hannah I. Bishop, Melanie M. Cobb, Michael Kirmiz, Laxmi K. Parajuli, Danielle Mandikian, Ashleigh M. Philp, Mikhail Melnik, Juha Kuja-Panula, Heikki Rauvala, Ryuichi Shigemoto, Karl D. Murray, James S. Trimmer
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Masashi Ikuno, Hodaka Yamakado, Hisako Akiyama, Laxmi Kumar Parajuli, Katsutoshi Taguchi, Junko Hara, Norihito Uemura, Yusuke Hatanaka, Katsumi Higaki, Kousaku Ohno, Masaki Tanaka, Masato Koike, Yoshio Hirabayashi, Ryosuke Takahashi
HUMAN MOLECULAR GENETICS
(2019)
Review
Biochemistry & Molecular Biology
Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Masato Koike
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Anatomy & Morphology
Laxmi Kumar Parajuli, Masato Koike
Summary: EM is essential for visualizing synaptic morphology and quantifying synaptic transmission parameters. Automated EM tools have improved throughput for imaging and reconstructing dendritic segments effectively.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Physiology
Parashar Thapa, Robert Stewart, Rebecka J. Sepela, Oscar Vivas, Laxmi K. Parajuli, Mark Lillya, Sebastian Fletcher-Taylor, Bruce E. Cohen, Karen Zito, Jon T. Sack
Summary: Thapa et al. present a method to label Kv2 potassium channels in live tissue using a variant of the tarantula toxin Guangxitoxin-1E and to image them using two-photon microscopy. Their approach enables the inference of conformational changes in situ from changes in fluorescence intensity.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Proceedings Paper
Computer Science, Cybernetics
Daisuke Shimotoku, Tian Yuan, Laxmi Kumar Parajuli, Hill Hiroki Kobayashi
Summary: This paper discusses the importance of Human Computer Biosphere Interaction (HCBI) as an academic discipline and presents the use of bio-acoustic technologies in wildlife conservation research in Fukushima, Japan. Based on a site visit to Manang and informal interactions with locals and conservation specialists, the authors provide a preliminary perspective on the feasibility of incorporating HCBI research in Manang, Nepal. The study suggests the potential of employing ICT tools for wildlife monitoring to empower locals engaged in subsistence farming.
DISTRIBUTED, AMBIENT AND PERVASIVE INTERACTIONS: SMART LIVING, LEARNING, WELL-BEING AND HEALTH, ART AND CREATIVITY, PT II
(2022)
Article
Neurosciences
Laxmi Kumar Parajuli, Hidetoshi Urakubo, Ai Takahashi-Nakazato, Roberto Ogelman, Hirohide Iwasaki, Masato Koike, Hyung-Bae Kwon, Shin Ishii, Won Chan Oh, Yugo Fukazawa, Shigeo Okabe
Article
Neurosciences
Yu-Shin Sou, Soichiro Kakuta, Yuji Kamikubo, Kazue Niisato, Takashi Sakurai, Laxmi Kumar Parajuli, Isei Tanida, Hiromitsu Saito, Noboru Suzuki, Kenji Sakimura, Yusuke Maeda, Taroh Kinoshita, Yasuo Uchiyama, Masato Koike
Review
Neurosciences
Laxmi Kumar Parajuli, Shinji Tanaka, Shigeo Okabe
BRAIN RESEARCH BULLETIN
(2017)