期刊
BMC MICROBIOLOGY
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12866-019-1692-3
关键词
Rapid ResaPolymyxin Acinetobacter; Pseudomonas NP test; Colistin-resistant; Gram-negative bacteria; Rapid diagnosis
类别
资金
- National Natural Science Foundations of China [81971986]
- General Scientific Research Project of the Education Department of Zhejiang Province of China [Y201942210]
- Planned Science and Technology Project of Wenzhou [Y20170204]
Background Colistin resistance is considered a serious problem due to a lack of alternative antibiotics. The Rapid ResaPolymyxin Acinetobacter/Pseudomonas NP test is a resazurin reduction-based technique that relies on the visual detection of bacterial growth in the presence of a defined concentration of colistin. The aim of this study was to evaluate the performance of the Rapid ResaPolymyxin Acinetobacter/Pseudomonas NP test in the detection of colistin susceptibility in common clinical Gram-negative bacteria. Results A total of 253 clinical isolates from a teaching hospital, including Acinetobacter baumanii (n = 58, 8 colistin-resistant), Pseudomonas aeruginosa (n = 61, 11 colistin-resistant), Klebsiella pneumoniae (n = 70, 20 colistin-resistant) and Escherichia coli (n = 64, 14 colistin-resistant) were tested in this study. The sensitivity and specificity of the Rapid ResaPolymyxin Acinetobacter/Pseudomonas NP test compared to Broth microdilution method was 100 and 99%, respectively. Conclusions Our results suggest that Rapid ResaPolymyxin Acinetobacter/Pseudomonas NP test could be used as an accurate detection method for colistin resistance.
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