Article
Materials Science, Biomaterials
Xiufang Li, Renchuan You, Qiang Zhang, Shuqin Yan, Zuwei Luo, Jing Qu, Mingzhong Li
Summary: The research aims to improve cell transplantation efficacy by utilizing scaffolds with nanofibrous microstructure for cell colonization and vascularization. Experimental results demonstrate that multiscale hierarchical design significantly enhances the ability of transplanted cells to promote neovascularization and tissue reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Review
Nanoscience & Nanotechnology
Yu-Guo Yuan, Jia-Lin Wang, Ya-Xin Zhang, Ling Li, Abu Musa Md Talimur Reza, Sangiliyandi Gurunathan
Summary: This review discusses the potential function of mesenchymal stem cell-derived exosomes (MSCs-EXOs) in various diseases including neurological, cancer, autoimmune, and inflammatory diseases. It also highlights the potential use of MSCs-EXOs in treating COVID-19 inflammatory disease. Additionally, it provides an overview of exosome biogenesis, factors regulating it, strategies, and challenges of using MSCs-EXOs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Zhaoyang Chen, Bowen Zhang, Jun Shu, Haiyang Wang, Yudi Han, Quan Zeng, Youbai Chen, Jiafei Xi, Ran Tao, Xuetao Pei, Wen Yue, Yan Han
Summary: Biological scaffolds based stem cell delivery using a hydrogel made from human decellularized adipose matrix show promising results in accelerating chronic wound healing. The hydrogel supports survival and proliferation of stem cells, and enhances paracrine activity. In diabetic mouse model experiments, the composite treatment led to faster wound closure and increased neovascularization.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Anatomy & Morphology
Alparslan Okcu, Yusufhan Yazir, Turgay Simsek, Serap Mert, Gokhan Duruksu, Ahmet Ozturk, Kamil Can Kilic, Gurler Akpinar, Murat Kasap
Summary: The study aimed to develop a therapeutic approach for T1DM by encapsulating pancreatic islets with mesenchymal stem cells and decellularized pancreatic extracellular matrix. The decellularized matrix was proven to be free of cells and genetic material, and supported the growth and maintenance of the islet cells. The encapsulated cells demonstrated improved insulin expression compared to non-encapsulated islets, but the efficiency of insulin secretion did not meet expectations.
Article
Cell & Tissue Engineering
Beilei Ma, Tengkai Wang, Juan Li, Qian Wang
Summary: This study found that ECM derived from Wharton's Jelly-derived mesenchymal stem cells could improve the angiogenesis ability of HUVECs in vitro in a time-dependent manner. Mechanically, WJ-MSCs ECM activated the FAK/P38 signaling pathway via integrin alpha V beta 3 to promote c-Myc expression, subsequently increasing VEGF expression through P300-mediated histone acetylation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Hideaki Kojima, Hiroko Kushige, Hiroshi Yagi, Takayuki Nishijima, Nobuko Moritoki, Narihito Nagoshi, Yutaka Nakano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Minoru Kitago, Masaya Nakamura, Yuko Kitagawa
Summary: Cell transplantation using mesenchymal stem cells (MSCs) has shown promising results for repairing and regenerating injured organs. However, the survival and retention of MSCs remain a challenge. This study investigated the co-transplantation of MSCs with decellularized extracellular matrix (dECM) hydrogels and found that it improved the survival rate of engrafted cells and demonstrated therapeutic effects in a rat pancreatitis model.
CELL TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Lysann M. Kroschwald, Felix Allerdt, Anne Bernhardt, Sandra Rother, Kai Zheng, Iram Maqsood, Norbert Halfter, Christiane Heinemann, Stephanie Moeller, Matthias Schnabelrauch, Michael C. Hacker, Stefan Rammelt, Aldo R. Boccaccini, Vera Hintze
Summary: The study demonstrates that aECM containing BGN can promote osteogenic differentiation of hMSC while delaying cellular growth, with a stimulating effect on ALP activity and calcium deposition. Some donors show a synergistic effect between sGAG and BGN, contributing to bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Qian Zhang, Yixin Hu, Xuan Long, Lingling Hu, Yu Wu, Ji Wu, Xiaobing Shi, Runqi Xie, Yu Bi, Fangyuan Yu, Pinxue Li, Yu Yang
Summary: Cartilage regeneration relies on cellular-ECM interactions. Traditional tissue engineering methods have not been able to replicate the physiological structure of natural cartilage, but recent advances in ECM-based scaffolds show promise in improving cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Jiang, Xin-Rui Lai, Jin-Qiang Lu, Ling-Zhi Tang, Jin-Rong Zhang, Hong-Wei Liu
Summary: DAT interacts with various types of MSCs to achieve adipose regeneration. It provides an inductive microenvironment for adipogenesis and supports the expression of PPARg. The presence of multiple adipogenic proteins in DAT plays a vital role in adipose regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Min Gong, Min Wang, Jie Xu, Bin Yu, Yi-Gang Wang, Min Liu, Muhammad Ashraf, Meifeng Xu
Summary: The genetically modified MSCs with GATA-4 overexpression released EVs that had an increased capacity for promoting angiogenesis, likely due to the delivery of let-7 miRs targeting THBS1 in endothelial cells.
Article
Cell & Tissue Engineering
Li-Li Zhang, Yu-Yan Xiong, Yue-Jin Yang
Summary: Acute myocardial infarction (AMI) is a condition of ischemic myocardial necrosis caused by acute coronary artery occlusion, with treatment focusing on reperfusion therapy and promoting angiogenesis. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have shown potential in promoting angiogenesis to improve cardiac function post-AMI, providing a basis for developing improved MSC-based methods in clinical treatment. Identifying the mechanisms behind MSCs and their derived EVs in promoting angiogenesis can pave the way for novel approaches utilizing MSCs to enhance angiogenesis capability in treating AMI.
STEM CELLS AND DEVELOPMENT
(2021)
Review
Immunology
Min Jiang, Xupin Jiang, Hongmei Li, Can Zhang, Ze Zhang, Chao Wu, Junhui Zhang, Jiongyu Hu, Jiaping Zhang
Summary: Diabetic foot is a common complication of diabetes and often leads to amputation. Previous studies have shown that stem cell transplantation can promote the healing of chronic diabetic wounds, but safety concerns have limited its clinical application. Recently, it has been discovered that mesenchymal stem cell-derived extracellular vesicles (EVs) have similar therapeutic effects and offer advantages such as safety and reduced immune response. This paper summarizes the current understanding of mesenchymal stem cell-derived EVs in accelerating the healing of diabetic wounds and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Assaf Assis, Yechiel N. Gellman, Avivit Cahn, Amir Haze, Sandra Camargo, Eduardo Mitrani
Summary: Research shows that MSCs extracted from patients with diabetic foot ulcers, when seeded on decellularized micro-fragments, transcribe and secrete angiogenic factors in amounts comparable to MSCs from healthy individuals, which may contribute to wound healing.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Surgery
Guillaume Levenson, Arthur Berger, Jonathan Demma, Guillaume Perrod, Thomas Domet, Lousineh Arakelian, Patrick Bruneval, Chloe Broudin, Mohamed Jarraya, Niclas Setterblad, Gabriel Rahmi, Jerome Larghero, Pierre Cattan, Lionel Faivre, Tigran Poghosyan
Summary: This study evaluated the feasibility of esophageal replacement using decellularized esophagus in a porcine model. The results showed that circumferential esophageal replacement with decellularized esophagus was feasible and allowed tissue remodeling. However, the study did not demonstrate any benefit from omental maturation or recellularization with mesenchymal stromal cells.