期刊
BIOSENSORS & BIOELECTRONICS
卷 150, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111947
关键词
Anticancer drug; Antibiotic drug; Simultaneous determination; Carbon quantum dot; Co3O4
类别
资金
- UGC -BSR [25-1/2014 -2015(BSR)/7-88/2007(BSR)]
- RUSA-Phase 2.0 grant, Department of Education, Govt. of India [F. 24-51/2014-U]
The simultaneous determination of anticancer and antibiotic drugs in biological samples with fast and sensitive methods is an essential task for the effective monitoring of drug therapy. A novel electrochemical sensor for the simultaneous determination of anticancer drug Flutamide (FLU) and antibiotic drug Nitrofurantoin (NF) was developed based on the glassy carbon electrode (GCE) modified with N-CQD@Co3O4/MWCNTs hybrid nano-composite. The electro-kinetics of the developed sensor was studied using cyclic voltammetry (CV). The electrochemical performance of FLU and NF on the N-CQD@Co3O4/MWCNTs/GCE surface was examined using CV and differential pulse voltammetry (DPV) techniques. At an optimized condition, the developed sensor exhibits excellent performance in simultaneous determination of FLU and NF with a linear range of 0.05-590 mu M and 0.05-1220 mu M and detection limit of 0.0169 mu M and 0.044 mu M respectively. Furthermore, the developed sensor exhibits satisfactory results in the real sample analysis.
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