Article
Chemistry, Multidisciplinary
Huixi Yi, Gaoyang Yan, Jinzhen He, Jiani Zhuang, Chengzhi Jin, Dong-Yang Zhang
Summary: In this study, polyvinylpyrrolidone-functionalized tantalum nitride nanoparticles (TaN-PVP NPs) were developed for photoacoustic imaging (PAI)-guided photothermal therapy (PTT) of cancer in the second near-infrared (NIR-II) window. The TaN-PVP NPs exhibited good photothermal conversion performance and PAI/PTI capabilities, providing real-time monitoring and guidance for cancer treatment.
Article
Chemistry, Physical
Tao Chen, Lichao Su, Lisen Lin, Xiaoguang Ge, Feicheng Bai, Meng Niu, Chenlu Wang, Jibin Song, Shaolei Guo, Huanghao Yang
Summary: This study presents a novel theranostics nanoplatform for cancer therapy and diagnosis, incorporating tungsten trioxide, gold nanoparticles, and up-conversion nanoparticles. The nanoplatform improves photoacoustic imaging performance and acts as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Additionally, it accurately guides cancer radiotherapy and reduces side effects on normal tissues.
Article
Nanoscience & Nanotechnology
Wonjun Yim, Jiajing Zhou, Yash Mantri, Matthew N. Creyer, Colman A. Moore, Jesse Jokerst
Summary: This study presents monodisperse GNR-melanin nanohybrids with a tunable polydopamine (PDA) coating that significantly enhances the photoacoustic (PA) signal compared to pristine GNRs. The PA signal of GNR@PDAs only decreased by 29% during 5 minutes of laser illumination in the NIR-II window, while significant attenuation (77%) was observed for GNRs. The PDA-coating provides a rational design for robust PA imaging probes and offers opportunities for other photomediated biomedicines.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Xiang Rong, Xiang Xia, Ran Wang, Zehou Su, Ting Liu, Zongwei Zhang, Saran Long, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: The combination of near-infrared molecular dyes and polymeric nanoparticles can be used for tumor photothermal therapy with strong photothermal effect and high targeting capacity, effectively inhibiting tumor growth.
Article
Chemistry, Analytical
Jiayingzi Wu, Liyan You, Saadia T. Chaudhry, Jiazhi He, Ji-Xin Cheng, Jianguo Mei
Summary: This study presents a pH-activatable and aggregation-enhanced NIR-II PA probe, utilizing oxygen-doped polymer to achieve water-solubility at physiological pH and aggregation in acidic environment for enhanced PA signal. The probe shows promise for specific diagnosis of acidic tumor microenvironment in vivo and paves the way for new activatable NIR-II imaging probes.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhuo Jia, Rong Dai, Ziliang Zheng, Yufei Qin, Ailin Duan, Xiaoyang Peng, Xianmei Xie, Ruiping Zhang
Summary: The newly developed NIR-II bio-window, with higher spatiotemporal resolution and tissue penetration depth, has attracted attention for its therapeutic efficacy. A nanotheranostic platform was designed by loading ammonia borane into hollow carbon nanoparticles, achieving efficient tumor treatment.
Review
Pharmacology & Pharmacy
Houjuan Zhu, Bofan Li, Chui Yu Chan, Beverly Low Qian Ling, Jiaqian Tor, Xin Yi Oh, Wenbin Jiang, Enyi Ye, Zibiao Li, Xian Jun Loh
Summary: Phototheranostic based on photothermal therapy (PTT) and photoacoustic imaging (PAI) is gaining attention due to its noninvasive, deeply penetrative, and highly selective and effective therapy. Single-component inorganic nanostructures are novel and attractive PAI and PTT combined nanotheranostic agents. They have controllable structure, tunable physiochemical properties, size-dependent optical properties, simple composition, and easy synthesis process. They also have multiple therapeutic and imaging functions, reducing systemic side effects and improving the bioavailability.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Qing Xu, Danyang Li, Haijun Zhou, Biaoqi Chen, Junlei Wang, Shi-Bin Wang, Aizheng Chen, Nina Jiang
Summary: The synthesis of MnO2-coated porous Pt@CeO2 core-shell nanostructures (Pt@CeO2@MnO2) offers a new theranostic nano-platform with high photothermal conversion efficiency and multifunctional therapeutic properties. The combination of Pt core and porous CeO2 interlayer allows for photothermal therapy, photoacoustic imaging, and photodynamic therapy. DOX-loaded Pt@CeO2@MnO2 demonstrates remarkable therapeutic outcomes in vitro and in vivo, providing a potential avenue for designing high-performance nano-platforms.
Article
Engineering, Biomedical
Yichen He, Yi Pan, Xin Zhao, Weijiao Fan, Yu Cai, Xiaozhou Mou
Summary: In this study, a novel NIR-II optical absorptive conjugated polymer (PDTP-TBZ) was successfully constructed by combining an intense electron donor dithienopyrrole (DTP) with a strong electron acceptor thiadiazolobenzotriazole (TBZ). The c(RGDfK) cyclic peptide was then modified on the surface of PT NPs to obtain multifunctional nanodiagnostic reagents (cRGD@PT NPs) that can effectively target GBM neovascularization and tumor cells. Both in vitro and in vivo experiments demonstrated that cRGD@PT NPs possess high photothermal conversion efficiency and practical photoacoustic imaging capability under 1064 nm laser irradiation. The results of this study suggest that cRGD@PT NPs have great potential in efficient NIR-II PTT guided by accurate PAI, which provide a good perspective for the treatment and diagnosis of GBM.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Jinling Li, Hui-Ling Peng, Changchun Wen, Peijing Xu, Xing-Can Shen, Cunji Gao
Summary: In this study, a NIR-II light-induced nanotheranostic CeO2-x@HA was successfully constructed, which achieved efficient SDT-enhanced PDT/PTT for precise tumor elimination using its photoacoustic conversion and ultrasound irradiation properties.
Article
Engineering, Environmental
Jie Mao, Yang Li, Qipeng Cai, Zhenbin Tang, Yuxin Yang, Conghui Yuan, Yiting Xu, Birong Zeng, Weiang Luo, Shiaowei Kuo, Lizong Dai
Summary: The use of hollow metallosupramolecular polymer nanoparticles allows for easy in-situ cargo encapsulation, reversible surface charge evolution, and excellent photoacoustic properties, resulting in a powerful photothermal-chemo therapeutic effect. Additionally, the nanoparticles exhibit self-charge generation ability, prolonged circulation, and tumor recognition, while also accelerating drug release in acidic environments, ultimately showing synergistic antitumor efficiency for potential cancer theranostic application.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Tao Guo, Qiuyu Tang, Yating Guo, Honglong Qiu, Jing Dai, Chao Xing, Shihao Zhuang, Guoming Huang
Summary: Photothermal therapy is a promising new tumor treatment method, and the study found that the synthesized boron quantum dots have excellent biological safety and high photothermal conversion ability, making them suitable for tumor photothermal therapy applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Aihui Sun, Tingting Li, Tian Jin, Yaxi Li, Kai Li, Chaolong Song, Lei Xi
Summary: A novel acoustic standing wave aided multiparametric photoacoustic imaging flow cytometry system is proposed, which can accurately identify multiple types of cells and image and capture melanoma cells at a lowest concentration of 100 cells mL-1 in pure blood. The system shows great potential for precise and efficient cell detection, manipulation, and elimination in both fundamental and clinical studies.
ANALYTICAL CHEMISTRY
(2021)
Article
Acoustics
Soon-Woo Cho, Thi Tuong Vy Phan, Van Tu Nguyen, Sang Min Park, Hwidon Lee, Junghwan Oh, Chang-Seok Kim
Summary: In this paper, an efficient label-free in vivo photoacoustic (PA) imaging method for melanoma using a condensed near infrared-I (NIR-I) supercontinuum light source is proposed. The light source emitting from visible (532-600 nm) to NIR-I (600-1000 nm) is demonstrated by optimizing stimulated Raman scattering induced supercontinuum generation. The melanoma's structure is successfully differentiated from blood vessels at a high pulse energy of 2.5 mu J and a flexible pulse repetition rate (PRR) of 5-50 kHz.
Review
Engineering, Biomedical
Shanshan Jiang, Jing Lin, Peng Huang
Summary: This review summarizes the recent advances in nanomaterials for photoacoustic imaging (PAI) in the second near-infrared window (NIR-II) and discusses the advantages of NIR-II PAI and its applications in the biomedical field. The nanomaterials-based PA contrast agents are categorized into organic, inorganic, and organic/inorganic hybrid nanomaterials, which are mainly used for imaging and diagnosis of tumor tissues, brain vasculature, inflammation, and other tissues, as well as for monitoring catalytic reaction processes in vivo. The opportunities and challenges of NIR-II PAI are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chu Tang, Yang Du, Qian Liang, Zhen Cheng, Jie Tian
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Hua Zhu, Te-li Liu, Chang-hao Liu, Jing Wang, Hong Zhang, Bin Dong, Jing Shen, Chuan-ke Zhao, Zhen-fu Li, Zhen Cheng, Zhi Yang
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Nanoscience & Nanotechnology
Xunzhi Wu, Yongkuan Suo, Hui Shi, Ruiqi Liu, Fengxia Wu, Tingzhong Wang, Lina Ma, Hongguang Liu, Zhen Cheng
NANO-MICRO LETTERS
(2020)
Article
Materials Science, Multidisciplinary
Bulin Du, Chunrong Qu, Kun Qian, Ying Ren, Yesen Li, Xiaohong Cui, Shuqing He, Yifan Wu, Timothy Ko, Ruiqi Liu, Xuena Li, Yaming Li, Zhen Cheng
ADVANCED OPTICAL MATERIALS
(2020)
Review
Biochemistry & Molecular Biology
Zhenhua Hu, Wen-Hua Chen, Jie Tian, Zhen Cheng
TRENDS IN MOLECULAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Yonggang Liu, Taylor Hanley, Hao Chen, Steven R. Long, Sanjiv S. Gambhir, Zhen Cheng, Joseph C. Wu, Georges El Fakhri, Bahman Anvari, Raiyan T. Zaman
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Xinli Xie, Ning Tu, Qi Wang, Zhen Cheng, Xingmin Han, Lihong Bu
Article
Chemistry, Multidisciplinary
Ning Zhao, Bingbing Ding, Ying Zhang, Jessica L. Klockow, Ken Lau, Frederick T. Chin, Zhen Cheng, Hongguang Liu
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Nanoscience & Nanotechnology
Huijun Zhou, Qing Zhang, Yan Cheng, Lili Xiang, Guohua Shen, Xiaoai Wu, Huawei Cai, Daifeng Li, Hua Zhu, Ruiping Zhang, Lin Li, Zhen Cheng
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Deling Li, Qiang Liu, Qingrong Qi, Hui Shi, En-Chi Hsu, Weiyu Chen, Wenli Yuan, Yifan Wu, Sien Lin, Yitian Zeng, Zunyu Xiao, Lingyun Xu, Yanrong Zhang, Tanya Stoyanova, Wang Jia, Zhen Cheng
Article
Multidisciplinary Sciences
Jingjing Liang, Huifang Wang, Wenxiu Ding, Jianxiang Huang, Xuefei Zhou, Huiyang Wang, Xue Dong, Guangyao Li, Enguo Chen, Fei Zhou, Hongjie Fan, Jingya Xia, Bo Shen, Da Cai, Pengxun Lan, Hanliang Jiang, Jun Ling, Zhen Cheng, Xiangrui Liu, Jihong Sun
Article
Materials Science, Biomaterials
Lili Yang, Shanshan Liu, Jingjing Chu, Shuang Miao, Kai Wang, Qingwei Zhang, Yingyi Wang, Yadi Xiao, Lina Wu, Yang Liu, Longjian Yu, Caihong Yu, Xiang Liu, Mingxing Ke, Zhen Cheng, Xilin Sun
Summary: EGFR-targeted F-MPG and OH-MPG exhibit promising anti-tumor activity in NSCLC treatment with limited liver damage, making them promising drug candidates for further investigation in combating the deadly NSCLC.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yanjun Che, Sijia Feng, Jiangbo Guo, Junjun Hou, Xuesong Zhu, Liang Chen, Huilin Yang, Mo Chen, Yunxia Li, Shiyi Chen, Zhen Cheng, Zongping Luo, Jun Chen
Review
Immunology
Deling Li, Chirag B. Patel, Guofan Xu, Andrei Iagaru, Zhaohui Zhu, Liwei Zhang, Zhen Cheng
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
