Article
Cell Biology
Gang Ma, Guichen Li, Wufeng Fan, Yuanhong Xu, Shaowei Song, Kejian Guo, Zhe Liu
Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yali Yu, Guixiang Dong, Zijun Li, Yan Zheng, Zhisong Shi, Guanghui Wang
Summary: This study discovered that circ-LRP6 inhibits the proliferation, migration, and invasion of osteosarcoma cells by regulating the miR-141-3p/HDAC4/HMGB1 axis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haihong Hu, Yu Wang, Zhiyuan Qin, Wen Sun, Yanhong Chen, Jiaqi Wang, Yingying Wang, Jing Nie, Lu Chen, Sheng Cai, Lushan Yu, Su Zeng
Summary: In this study, miR-4524-5p was found to downregulate the expression of MRP4, and circHIPK3 was shown to regulate MRP4 expression by sponging miR-124-3p and miR-4524-5p for the first time. These results may offer new insights into preventing MRP4-related proliferation and multiple drug resistance in HCC.
Article
Biology
Ning Ding, Yu Zhang, Mengna Huang, Jianfeng Liu, Chonglong Wang, Chun Zhang, Jinkang Cao, Qin Zhang, Li Jiang
Summary: This study identified circ-CREBBP as a biomarker and therapeutic target for male reproductive diseases. It promotes sperm motility and inhibits apoptosis by sponging miR-10384 and miR-143-3p.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Qiang Tu, Xiaoxiang You, Jun He, Xuguang Hu, Changji Xie, Guohui Xu
Summary: The study revealed that circ-0003006 was upregulated in HCC tissues and promoted HCC progression by sponging miR-542-3p to release inhibition on HIF-1A, potentially acting as a sponge to regulate gene expression.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Surgery
Xiaojie Wang, Ying Zhang, Wei Li, Xiaolei Liu
Summary: The study demonstrates that circPVT1 can modulate chemoresistance and malignancy of gastric cancer by regulating HDGF expression via sponging miR-152-3p.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cell Biology
Guohai Xie, Xinyi Zheng, Zhong Zheng, Ruoyu Wu, Zhixian Yao, Wenjie Huang, Feng Sun, Xingyu Mu, Ke Wu, Junhua Zheng
Summary: The study investigates the role and mechanism of PVT1 in ccRCC, revealing its involvement in promoting cell proliferation through the PVT1-miR-328-3p-FAM193B loop. This finding suggests a potential biomarker and therapeutic target for ccRCC.
Article
Cell Biology
Xuan Guo, Ziying Wang, Xue Deng, Yantong Lu, Xuhui Huang, Juze Lin, Xiaohe Lan, Qiao Su, Changjun Wang
Summary: This article investigates the role and biological function of circular RNA (circRNA) in the occurrence of hepatocellular carcinoma (HCC). The study found that circITCH is downregulated in HCC cells and regulates proliferation, invasion, and apoptosis of HCC through interaction with miR-184. Additionally, circITCH may serve as a potential prognostic marker and therapeutic target for HCC.
Article
Biochemistry & Molecular Biology
Weiwei Liu, Lu Zheng, Rongguiyi Zhang, Ping Hou, Jiakun Wang, Linquan Wu, Jing Li
Summary: High expression of circ-ZEB1 and PIK3CA is associated with poor prognosis in HCC. Circ-ZEB1 promotes the expression of PIK3CA by silencing miR-199a-3p, affecting HCC proliferation and apoptosis.
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yongbin Chi, Wenlong Zheng, Guangyu Bao, Lifeng Wu, Xiaoxue He, Ruyi Gan, Yan Shen, Xudong Yin, Mingming Jin
Summary: A novel circular RNA, hsa_circ_103820, was identified in lung cancer, showing potential tumor suppressive function by inhibiting proliferation, migration, and invasion of cancer cells. The mechanism involves the direct targeting of miR-200b-3p by hsa_circ_103820 and the regulation of downstream target genes LATS2 and SOCS6.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jie Shang, Huizi Li, Biao Wu, Ning Jiang, Bin Wang, Dawei Wang, Junlong Zhong, Yufeng Chen, Xianghe Xu, Huading Lu
Summary: circHIPK3 regulates chondrocyte apoptosis through the mitochondrial pathway, and its interaction with miR-30a-3p and PON2 may serve as potential targets for osteoarthritis treatment.
CELL PROLIFERATION
(2022)
Article
Medicine, Research & Experimental
Yuanshan Yao, Yinjie Zhou, Qingwang Hua
Summary: Our research revealed that circ_0018414 functions as a tumor inhibitor in LUAD by inhibiting cell proliferation and stemness while promoting apoptosis. Furthermore, circ_0018414 upregulation led to inactivation of the Wnt/beta-catenin pathway by enhancing the expression of DKK1 through sponging miR-6807-3p. This study suggests a potential therapeutic target for LUAD treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Yang Li, Xiu Hong, Jingfang Zhai, Ying Liu, Rui Li, Xiuli Wang, Youwei Zhang, Qian Lv
Summary: In this study, it was found that circ-0002727 regulates the progression of lung adenocarcinoma by modulating the miR-144-3p/KIF14 pathway, providing a potential therapeutic target for LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Dermatology
Fandong Meng, Fengjie Shen, Hongwei Ling, Peisheng Jin, Dongmei Zhou, Qiang Li
Summary: This study reveals that high glucose treatment decreases the expression of circARHGAP12 in MSCs, while circARHGAP12 regulates high glucose-induced apoptosis in MSCs through mediating autophagy. Mechanistically, circARHGAP12 directly interacts with miR-301b-3p and modulates the expression of its downstream target genes, ATG16L1 and ULK2, and the signaling pathway. Furthermore, circARHGAP12 promotes the survival of MSCs in diabetic wounds and accelerates wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)