Article
Biochemistry & Molecular Biology
A-Mohsen M. E. Omar, Omaima M. AboulWafa, Mai E. Amr, Mai S. El-Shoukrofy
Summary: Novel benzoxazole derivatives were synthesized and evaluated for their anticancer activities, showing selectivity towards breast cancer cells and promising apoptosis-inducing properties. Compound 7a and 8e demonstrated potent inhibition of EGFR and ARO enzymes, highlighting their potential as anti-breast cancer agents.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Alex Zohmachhuana, Malsawmdawngliana, F. Lalnunmawia, Vabeiryureilai Mathipi, K. Lalrinzuali, N. Senthil Kumar
Summary: The aim of this study was to evaluate the phytochemical content, antioxidant and anti-cancer activities of different parts of Curcuma aeruginosa Roxb. The methanol extracts from C. aeruginosa showed cytotoxicity against lung adenocarcinoma and cervical cancer cells, induced DNA damage, and up-regulated caspase activity. Additionally, bioactive compounds identified from the plant have been found to possess anti-cancer properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Leila Emami, Sara Sadeghian, Ayyub Mojaddami, Soghra Khabnadideh, Amirhossein Sakhteman, Hossein Sadeghpour, Zeinab Faghih, Masood Fereidoonnezhad, Zahra Rezaei
Summary: In this study, we synthesized nineteen novel 1,2,4-triazole derivatives and confirmed their structures using spectroscopic techniques. The cytotoxic activities of the synthesized compounds were evaluated against human cancer cell lines, and several compounds showed promising cytotoxic activity against the Hela cell line. The safety of these compounds was also assessed, and they exhibited proper selectivity against normal and cancerous cell lines. Additionally, molecular docking studies were conducted to understand the binding modes and mechanisms of these derivatives in the binding pocket of the aromatase enzyme as a potential target.
Article
Materials Science, Multidisciplinary
A. A. Salim, H. Bakhtiar, Dawood Ali Salim Dawood, S. K. Ghoshal
Summary: Surface functionalized silver-cinnamon nanoshells (Ag-CNSs) were synthesized using PLAL method and characterized. The anticancer effectiveness and cytotoxicity of Ag-CNSs against liver hepatocellular carcinoma cancer (HepG2) and normal (WRL68) cell lines were evaluated. The Ag-CNSs exhibited strong anticancer activity and improved fluorescence and surface plasmon resonance (SPR) absorption.
Article
Biochemistry & Molecular Biology
Somayeh Zare, Leila Emami, Marzieh Behrouz, Reza Abbasi Khankahdani, Shirin Nickpour, Mina Emami, Zeinab Faghih, Soghra Khabnadideh
Summary: A series of 6-bromoquinazoline derivatives were synthesized and their cytotoxic effectiveness against two cancerous cell lines was evaluated. All compounds showed desirable activity in reducing cell viability, with IC50 values ranging from 0.53 to 46.6 μM. Compound 5b, with a fluoro substitution at meta position of the phenyl moiety, exhibited stronger activity than cisplatin. Further studies revealed that compound 5b induced apoptosis in a dose-dependent manner and interacted with EGFR through molecular docking.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Plant Sciences
Bilques Farooq, Bhupendra Koul, Deveshi Mahant, Dhananjay Yadav
Summary: In the study, the Jaffna variety of Moringa oleifera leaf extracts demonstrated the highest antioxidant activity, making it a promising candidate for combating malnutrition and cancer.
Article
Biochemistry & Molecular Biology
H. Yasemin Yenilmez, Nazli Farajzadeh, Nilgun Guler Kusculu, Dilek Bahar, Sadin Ozdemir, Gulsah Tollu, Mithat Gullu, Zehra Altuntas Bayir
Summary: Three new axially disubstituted silicon phthalocyanines (SiPc1-3) and their quaternized phthalocyanine derivatives (QSiPc1-3) were synthesized and characterized. The water-soluble silicon phthalocyanines exhibited high antioxidant, antimicrobial, antibiofilm, and microbial cell viability activities, especially against Gram (+) bacteria. They also demonstrated DNA cleavage and binding features, as well as inhibition of the human topoisomerase I enzyme. Furthermore, they displayed anticarcinogenic activity against the DLD-1 colon cancer cell line. These compounds have potential as effective biological agents and anticancer drugs.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Environmental Sciences
Muhammad Zubair, Muhammad Azeem, Rabia Mumtaz, Madiha Younas, Muhammad Adrees, Errum Zubair, Abdullah Khalid, Farhan Hafeez, Muhammad Rizwan, Shafaqat Ali
Summary: Both cancer and diabetes are serious health issues with a high mortality rate worldwide. This study investigates the use of plant-mediated nanoparticles for the treatment of these diseases. Silver nanoparticles (AgNPs) were synthesized from Acacia nilotica bark extract and characterized using standard techniques. The study found that the plant-mediated AgNPs showed potential as an anticancer, antidiabetic, and antioxidant agent. Further research is needed to understand the molecular mechanisms behind the therapeutic effects.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Physical
Cynthia E. Theodore, G. Sivaiah, S. B. Benaka Prasad, K. Yogesh Kumar, M. S. Raghu, Fahd Alharethy, M. K. Prashanth, Byong-Hun Jeon
Summary: In this study, a new series of 1H-benzo[d]imidazole derivatives (10a-j) were designed, synthesized, and evaluated for their anticancer efficacy. The synthesized compounds were tested on MCF-7 and HCT116 cancer cell lines, showing cytotoxic effects and higher potency compared to the reference medication erlotinib. Compounds 10g, 10i, and 10j demonstrated strong anticancer efficacy against the tested cancer cell lines with good safety and selectivity indices, particularly against EGFR wild type and mutant EGFR L858R/T790M. Compound 10i exhibited the most inhibitory effect and higher selectivity than erlotinib.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Muhammad Ashraf, Ambar Iqbal, Saima Muzaffar, Samina Ejaz, Aziz-Ur-Rehman, Hafiz Mohammad Kashif Mahmood, Keshab Bhattarai
Summary: The correlation between inflammation, innate immunity, and cancer has been extensively studied, and researchers are now focusing on synthesizing new molecules with safer profiles to overcome the reported side effects and resistance of anti-inflammatory drugs. This study investigated the synthesis of a new series of 1,3,4-oxadiazole derivatives and evaluated their inhibitory potential against the soybean 15-LOX enzyme. The results showed excellent inhibitory activity of some compounds, as well as their low cellular viability in blood mononuclear cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
M. Shaheer Malik, Reem I. Alsantali, Qazi Mohammad Sajid Jamal, Zaki S. Seddigi, Moataz Morad, Meshari A. Alsharif, Essam M. Hussein, Rabab S. Jassas, Munirah M. Al-Rooqi, Zainularifeen Abduljaleel, Ahmed O. Babalgith, Hatem M. Altass, Ziad Moussa, Saleh A. Ahmed
Summary: An efficient atom-economical protocol for the synthesis of new imidazole-based N-phenylbenzamide derivatives was described, providing a series of compounds with high yields in a short reaction time. Cytotoxic evaluation showed that derivatives 4e and 4f exhibited good anticancer activity, with computational studies revealing their higher affinity towards target receptor proteins and stable complex formations. The ADME and drug-likeness of the derivatives reinforced their potential for further development as anticancer agents.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yanli Yang, Hongmei Sun, Nasser S. Awwad, Hala A. Ibrahium, Fatimah A. Alhomaid, Attalla F. El-kott, Mohamed M. Abdel-Daim
Summary: This study demonstrates the preparation and characterization of kaolin supported Au nanoparticles using Mentha extract as a green reluctant and capping agent. The study also evaluates the cytotoxicity and anti-cervical carcinoma properties of the prepared nanocomposite on different cervical carcinoma cell lines. The results show that the Au nanoparticles are homogeneously dispersed on the modified kaolin surface, and the nanocomposite exhibits dose-dependent reduction in the viability of malignant cervical cell lines.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Plant Sciences
Eman Fikry, Raha Orfali, Samar S. Elbaramawi, Shagufta Perveen, Azza M. El-Shafae, Maher M. El-Domiaty, Nora Tawfeek
Summary: Cancer is a major cause of death globally, and the essential oil from Chamaecyparis lawsoniana leaves (CLLEO) shows potential anticancer properties, making it a possible alternative treatment option.
Article
Chemistry, Physical
B. N. Nippu, Abdul Rahman, R. Sandeep Kumar Jain, K. S. Manjunatha, H. M. Kumaraswamy, K. M. Mahadevan, N. D. Satyanarayan
Summary: Pancreatic cancer is a devastating disease with a low survival rate. In this study, new molecules with a pyridine moiety were designed and synthesized for anticancer research. Computational screening and molecular docking were performed to identify drugable ligands that comply with ADMET parameters. The synthesis was successfully carried out and the molecules showed potential anticancer activity in cell viability assays.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Oncology
Nishith Teraiya, Subhas S. Karki, Ashlesha Chauhan
Summary: This study synthesized new compounds and screened them for cytotoxicity. The active compound induced apoptosis by regulating the cell cycle, inhibiting the anti-apoptotic protein Mcl-1, and activating the pro-apoptotic proteins caspase-3 and caspase-9.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Adnan A. Bekhit, Ahmed M. Farghaly, Ragab M. Shafik, Mona M. A. Elsemary, Alaa El-Din A. Bekhit, Aida A. Guemei, Mai S. El-Shoukrofy, Tamer M. Ibrahim
BIOORGANIC CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Mohamed A. Abdelsalam, Omaima M. AboulWafa, El-Sayed A. M. Badawey, Mai S. El-Shoukrofy, Mostafa M. El-Miligy, Noha Gouda, Mahmoud M. Elaasser
FUTURE MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Mohamed A. Abdelsalam, Omaima M. AboulWafa, El-Sayed A. M. Badawey, Mai S. El-Shoukrofy, Mostafa M. El-Miligy, Noha Gouda
FUTURE MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Ahmed M. Farghaly, Omaima M. AboulWafa, Yaseen A. M. Elshaier, Waleed A. Badawi, Haridy H. Haridy, Heba A. E. Mubarak
MEDICINAL CHEMISTRY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Mai S. El-Shoukrofy, Heba A. Abd El Razik, Omaima M. AboulWafa, Aida E. Bayad, Ibrahim M. El-Ashmawy
BIOORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Maha S. Almutairi, Areej N. Al Suwayyid, Amal Aldarwesh, Omaima M. Aboulwafa, Mohamed I. Attia
Article
Biochemistry & Molecular Biology
Omaima M. AboulWafa, Hoda M. G. Daabees, Waleed A. Badawi
BIOORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
A-Mohsen M. E. Omar, Omaima M. AboulWafa, Mai E. Amr, Mai S. El-Shoukrofy
Summary: Novel benzoxazole derivatives were synthesized and evaluated for their anticancer activities, showing selectivity towards breast cancer cells and promising apoptosis-inducing properties. Compound 7a and 8e demonstrated potent inhibition of EGFR and ARO enzymes, highlighting their potential as anti-breast cancer agents.
BIOORGANIC CHEMISTRY
(2021)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)