Phase I metabolism of synthetic cannabinoid receptor agonist PX‐1 (5F‐APP‐PICA) via incubation with human liver microsomes and UHPLC–HRMS

Metabolic profiling of synthetic cannabinoid 5F-ADB by human liver microsome incubations and urine samples using high-resolution mass spectrometry.

(2019) Oya Yeter et al.   Drug Testing and Analysis

Structure-metabolism relationships of valine and tert-leucine-derived synthetic cannabinoid receptor agonists: a systematic comparison of the in vitro phase I metabolism using pooled human liver microsomes and high-resolution mass spectrometry

(2019) Florian Franz et al.   Forensic Toxicology

In‐Vitro Phase I Metabolism of Indazole Carboxamide Synthetic Cannabinoid MDMB‐CHMINACA via Human Liver Microsome Incubation and High‐Resolution Mass Spectrometry

(2019) Brandon C. Presley et al.   Drug Testing and Analysis

Synthetic cannabinoid use among college students

(2019) Eva M. Mathews et al.   ADDICTIVE BEHAVIORS

Comprehensive investigation on synthetic cannabinoids: Metabolic behavior and potency testing, using 5F‐APP‐PICA and AMB‐FUBINACA as model compounds

(2019) David Fabregat‐Safont et al.   Drug Testing and Analysis

In vitro metabolism of the synthetic cannabinoids PX‐1, PX‐2, and PX‐3 by high resolution mass spectrometry and their clearance rates in human liver microsomes

(2019) Travon Cooman et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Synthetic cannabinoids in hair – Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples

(2018) Florian Franz et al.   ANALYTICA CHIMICA ACTA

Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry

(2018) Xingxing Diao et al.   Forensic Toxicology

Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds

(2018) Clara T. Schoeder et al.   Forensic Toxicology

Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens

(2018) Alex J Krotulski et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

The ongoing challenge of novel psychoactive drugs of abuse. Part I. Synthetic cannabinoids (IUPAC Technical Report)

(2018) Vincenzo Abbate et al.   PURE AND APPLIED CHEMISTRY

N-Ethyl Pentylone (Ephylone) Intoxications: Quantitative Confirmation and Metabolite Identification in Authentic Human Biological Specimens

(2018) Alex J Krotulski et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: Update of the German situation in summer 2018

(2018) Ludger Ernst et al.   FORENSIC SCIENCE INTERNATIONAL

Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE

(2018) Lukas Mogler et al.   Forensic Toxicology

Synthetic cannabinoid hydroxypentyl metabolites retain efficacy at human cannabinoid receptors

(2018) Thomas F Gamage et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of a new tert -leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

(2017) Martijn D.P. Risseeuw et al.   FORENSIC SCIENCE INTERNATIONAL

Fatality Following Ingestion of Tetrahydrofuranylfentanyl, U-49900 and Methoxy-Phencyclidine

(2017) Alex J Krotulski et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Metabolic Profile Determination of NBOMe Compounds Using Human Liver Microsomes and Comparison with Findings in Authentic Human Blood and Urine

(2017) Keith-Dane H. Temporal et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues

(2016) Samuel D. Banister et al.   ACS Chemical Neuroscience

Freeze-thaw stability and long-term stability of 84 synthetic cannabinoids in serum

(2016) Cornelius Hess et al.   Drug Testing and Analysis

Simultaneous detection of 93 synthetic cannabinoids by liquid chromatography-tandem mass spectrometry and retrospective application to real forensic samples

(2016) Cornelius Hess et al.   Drug Testing and Analysis

In vitroandin vivohuman metabolism of the synthetic cannabinoid AB-CHMINACA

(2015) Claudio Erratico et al.   Drug Testing and Analysis

Synthetic cannabimimetic agents metabolized by carboxylesterases

(2014) Ragnar Thomsen et al.   Drug Testing and Analysis

Determination of AM-2201 metabolites in urine and comparison with JWH-018 abuse

(2013) Moonhee Jang et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism

(2013) Melanie Hutter et al.   JOURNAL OF MASS SPECTROMETRY

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

(2012) Lisa K. Brents et al.   BIOCHEMICAL PHARMACOLOGY

Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids

(2012) Tim Sobolevsky et al.   Drug Testing and Analysis

Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids

(2012) Kathryn A. Seely et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Identification and quantitation of a benzoylindole (2-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone and a naphthoylindole 1-(5-fluoropentyl-1H-indol-3-yl)-(naphthalene-1-yl)methanone (AM-2201) found in illegal products obtained via the Internet and their cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays

(2011) Jun’ichi Nakajima et al.   Forensic Toxicology

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity

(2011) Lisa K. Brents et al.   PLoS One

Investigating a not-so-natural high

(2009) Christine Piggee   ANALYTICAL CHEMISTRY

‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

(2009) Volker Auwärter et al.   JOURNAL OF MASS SPECTROMETRY