期刊
BIOMARKERS IN MEDICINE
卷 14, 期 2, 页码 87-95出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2019-0257
关键词
acute coronary syndrome; biomarker; major adverse cardiac events; miR-208b; miR-499
资金
- Traditional Chinese Medicine Science and Technology Development Plan Project of Shandong Province [2019-0891]
Aim: This study aimed to investigate the correlation between the expression of circulating miR-208b and miR-499 and acute coronary syndrome (ACS) patients. Materials & methods: A total of 160 consecutive patients with ACS and 48 healthy control subjects were enrolled for primary analysis. The ACS patients (n = 160) were followed up for 6 months for further analysis regarding major adverse cardiac events. Results: Area under the curve values of miR-208b and miR-499 for predicting ACS were 0.910 and 0.851 (p < 0.001, respectively). Cox proportional hazards regression analysis revealed that miR-208b but not miR-499 was an independent predictor of major adverse cardiac events. Conclusion: Circulating miR-208b and miR-499 could be considered as diagnostic or prognostic biomarkers for patients with ACS.
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