Review
Chemistry, Applied
Seid Reza Falsafi, Fuat Topuz, Hadis Rostamabadi
Summary: Dialdehyde carbohydrates (DCs) have diverse biomedical applications due to their versatile physical/chemical characteristics and biocompatibility/biodegradability. The cross-linking ability of DCs allows for the formation of versatile architectures, making them interesting matrices for applications such as drug delivery and tissue engineering. Recent progress in DCs has led to the development of advanced biomaterials in different forms, both macro and nano/micro, with potential for biomedical use. This review provides an update on the synthesis, properties, and applications of DCs, as well as addressing safety concerns and future perspectives.
CARBOHYDRATE POLYMERS
(2023)
Review
Polymer Science
Svyatoslav Nastyshyn, Yuriy Stetsyshyn, Joanna Raczkowska, Yuriy Nastishin, Yuriy Melnyk, Yuriy Panchenko, Andrzej Budkowski
Summary: This review summarizes the fabrication and characterization methods of temperature-responsive polymer brush coatings (TRPBCs), and presents their potential applications, advantages, and disadvantages. Special attention is given to the thermo-responsibility mechanisms of TRPBCs, and their applications in temperature-switchable bacteria killing, temperature-controlled protein adsorption, cell culture, and temperature-controlled adhesion/detachment of cells and tissues are considered. The specific criteria required for desired biomedical applications of TRPBCs are presented and discussed.
Article
Chemistry, Analytical
Lihua Shen, Daixin Ye, Hongbin Zhao, Jiujun Zhang
Summary: Single-atom nanozymes (SANs) are a new generation of nanozymes with dispersed single-atom structures and stable catalytic performance. This paper reviews the recent progress in SANs in terms of synthesis, functional mechanisms, performance validation, and biomedical applications.
ANALYTICAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Ying Wang, Shao-Kai Sun, Yang Liu, Zhanzhan Zhang
Summary: Hitchhiking, a bio-inspired cargo delivery system, utilizes the interactions between nanoparticles and circulatory cells or proteins to achieve efficient navigation, targeted delivery, and surveillance.
Review
Chemistry, Multidisciplinary
Wei Sang, Ruiping Zhang, Xiangyang Shi, Yunlu Dai
Summary: Nanofibers are wire-like materials with nanoscale diameters and specific length diameter ratios. Metallized nanofibers enhance the performance of conventional nanofibers through electrostatic spinning doping, chemical modification, and loading approaches. Due to their unique physical and chemical properties, metallized nanofibers have diverse applications in physical chemistry, materials science, and battery preparation, and are gradually expanding into the biomedical field.
Review
Engineering, Biomedical
Jinglin Wang, Xiangyi Wu, Junqi Zhao, Haozhen Ren, Yuanjin Zhao
Summary: This review comprehensively summarizes biomimetic liver microphysiological systems (MPSs), including their cellular composition, biomedical applications, challenges, and future development prospects. It introduces the key components of liver MPSs and their biomedical applications in disease modeling, drug metabolism, and toxicity testing. It also discusses the challenges faced by MPSs and proposes future research directions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Lukas Heuberger, Maria Korpidou, Olivia M. Eggenberger, Myrto Kyropoulou, Cornelia G. Palivan
Summary: Nano- and micrometer-sized compartments composed of synthetic polymers are designed to mimic spatial and temporal divisions found in nature. These compartments have a wide range of applications in imaging, theranostics, and modeling, and their properties can be tailored through polymer synthesis and functionalization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Partha Sikdar, Tanvir Mahady Dip, Avik K. Dhar, Maitry Bhattacharjee, Md. Saiful Hoque, Solaiman Bin Ali
Summary: This review paper outlines the recent advances of polyurethanes (PUs) in functional textiles, intelligent functionality, and medical applications. It provides a comprehensive discussion of the diverse structure and responsiveness of PUs under various conditions, as well as future challenges and research opportunities.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Polymer Science
Luis Alberto Mejia-Manzano, Patricia Vazquez-Villegas, Luis Vicente Prado-Cervantes, Kristeel Ximena Franco-Gomez, Susana Carbajal-Ocana, Daniela Lizeth Sotelo-Cortes, Valeria Atehortua-Benitez, Miguel Delgado-Rodriguez, Jorge Membrillo-Hernandez
Summary: Biofilms are living microorganism communities that pose a threat to the healthcare sector due to their association with health-related infections. This review provides an overview of biofilms and their formation, focusing on their relevance in biomedicine and advancements in materials to prevent or control biofilm formation. Biofilms are aggregates of cells in an extracellular matrix, offering protection to microorganisms in unfavorable environments. Staphylococcus spp., Escherichia spp., and Candida spp. are the most commonly reported microorganisms forming biofilms in medical implants and devices. In recent years, biofilms have been linked to health-associated infections and deaths globally. Smart, functional polymers show promise in combating biofilms through modification or synthesis of new materials.
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Article
Chemistry, Multidisciplinary
Shujun Cui, Jifu Mao, Mahmoud Rouabhia, Said Elkoun, Ze Zhang
Summary: Polymerization (PPy) is a widely studied conductive biomaterial, but its rigidity limits its practical applications. By reinforcing a soft PPy membrane with electrospun PU and PLLA fibers, this study has successfully enhanced its flexibility and tensile strength while maintaining electrical conductivity and cytocompatibility. The membrane shows promise for various biomedical applications.
Review
Biochemical Research Methods
Kai Pang, Sihan Dong, Yuxi Zhu, Xi Zhu, Quanyu Zhou, Bobo Gu, Wei Jin, Rui Zhang, Yuting Fu, Bingchen Yu, Da Sun, Duanmu Zheng, Xunbin Wei
Summary: Flow cytometry is a versatile tool for detecting and measuring characteristics of cells or particles. Recent advancements in techniques such as in vivo photoacoustic FC, coherent Raman FC, and microfluidic FC have expanded the applications of FC in basic research and clinical practice.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Chemistry, Multidisciplinary
Zhuohao Zhang, Yu Wang, Qiao Wang, Luoran Shang
Summary: Soft actuators, particularly smart film actuators (SFAs), have emerged as a promising technology in the biomedical field. This review summarizes the latest achievements of SFAs in terms of fabrication techniques, topology design, material selections, and actuating mechanisms. The authors categorize the biomedical applications and discuss the challenges and prospects of this field. The review aims to boost the development of soft robotics, biomimetics, and human healthcare.
Review
Chemistry, Multidisciplinary
Ziyi Wang, Chen Sun, Kuikun Yang, Xiaoyuan Chen, Ruibing Wang
Summary: Supramolecular polymers, with their unique features and functions, have attracted broad interest in diverse biomedical applications. This Minireview summarizes the recent progress in the design, fabrication, and biomedical applications of CB[n]-based supramolecular polymers (CSPs), categorized as noncovalent and covalent CSPs. The design principles, advantages, and future perspectives of CSPs in the field of biomedicine are also discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Engineering, Biomedical
Ziying Liang, Yingfeng Tu, Fei Peng
Summary: This review covers the fabrication and applications of polymer-based micro or nanomotors in biomedical areas, discussing both classic manufacturing approaches and cutting-edge techniques. Current challenges and future prospects are presented in the hope of facilitating practical translations of micro/nanomotors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Qingbo Wang, Wenyang Xu, Rajesh Koppolu, Bas van Bochove, Jukka Seppala, Leena Hupa, Stefan Willfor, Chunlin Xu, Xiaoju Wang
Summary: The study introduces an injectable nanocomposite hydrogel cured by light-induced thiol-ene addition, with features of faster crosslinking, more stable mechanics, and higher bioactivity, suitable for fabrication of digitally designed hydrogel constructs.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Rainhard Machatschek, Matthias Heuchel, Andreas Lendlein
Summary: Polyimides and polyetherimides (PEI) exhibit the capability to react with nucleophiles under mild conditions, allowing for surface properties adjustment through post-functionalization targeting phthalimide groups. Investigating surface functionalization using ultra-thin PEI films on a Langmuir trough, it was found that hydrolysis enhances film stability and activates ester formation. The direct amidation of PEI with Lewis acid catalyst resulted in free amine groups, showing a greater impact of hydrolysis on material properties when compared to amidation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kasper Dienel, Ahmed Abu-Shahba, Roman Kornilov, Roy Bjorkstrand, Bas van Bochove, Johanna Snall, Tommy Wilkman, Karri Mesimaki, Anna Meller, Jere Linden, Anu Lappalainen, Jouni Partanen, Riitta Seppanen-Kaijansinkko, Jukka Seppala, Bettina Mannerstrom
Summary: A major challenge in extensive craniomaxillofacial bone reconstruction is the limited availability of donor sites. This study tested patient-specific composite bioimplants in an animal model and found that they can induce bone growth but also have issues with resorption and infection.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Engineering, Manufacturing
Rishabh Magazine, Bas van Bochove, Sedigheh Borandeh, Jukka Seppala
Summary: The demand for optical components such as microlenses has been rapidly growing, but conventional manufacturing methods are often time-consuming and harmful to the environment. To overcome these issues, 3D inkjet printing has attracted attention as an alternative technique for fabricating microlenses. This review investigates the process of 3D inkjet printing and identifies key components and methodologies for controlling the properties of the resulting microlenses. The study finds that 3D inkjet printing offers high flexibility, scalability, efficiency, and the ability to produce high-quality microlenses. Substrate modification is shown to be a key method for controlling the geometric and optical properties of the microlenses.
ADDITIVE MANUFACTURING
(2022)
Article
Materials Science, Multidisciplinary
Shuo Zhou, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
Summary: Glycerol-based epoxy networks have great potential for surface functionalization, but the production process may lead to the presence of organochlorides, affecting cytotoxicity.
Article
Materials Science, Multidisciplinary
Shanshan Zhang, Yue Liu, Rainhard Machatschek, Andreas Lendlein
Summary: We report the successful production of cohesive and well-organized type I collagen ultrathin films of about 10 nm thickness using the Langmuir-Blodgett technique. Investigation of molecular behavior at the air-water interface reveals the existence and disappearance of a network structure in the protein nanosheet. Highly aligned and fibrillar structures are observed by atomic force microscopy and optical microscopy.
Article
Energy & Fuels
Natalia A. Tarazona, Rainhard Machatschek, Jennifer Balcucho, Andreas Lendlein, Jinneth Lorena Castro-Mayorga, Juan F. Saldarriaga
Summary: The production and consumption of commodity polymers are crucial for the development of modern society. Polymer-based materials play important roles in various fields such as healthcare, transport, food preservation, construction, electronics, and water management. However, considering the environmental crisis caused by plastic consumption, advanced polymers should incorporate functions that meet application demands and minimize environmental harm. This article discusses strategies to enhance the sustainability of plastics, including measuring and reducing negative impacts, using renewable sources for synthesis, designing biodegradable and recyclable materials, and enzymatic recycling for a circular bioeconomy. International cooperation is also emphasized for achieving the Sustainable Development Goals (SDGs) through leading-edge polymer-based materials.
MRS ENERGY & SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Falk Hoffmann, Rainhard Machatschek, Andreas Lendlein
Summary: This study investigates the degradation of polymers using mathematical models, comparing different chain cut mechanisms and analyzing the influence of internal molecular parameters. The results show that the shape of the degradation curve is similar for both chain cut mechanisms, and a characteristic time and maximum length of soluble fragments can be extracted to enhance the description and design of polymers.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hanieh Moradian, Toralf Roch, Larissa Anthofer, Andreas Lendlein, Manfred Gossen
Summary: In vitro transcribed (IVT)-mRNA is a promising therapeutic modality that can be tailored to modulate innate immune responses of human cells. Uridine modifications were found to be particularly important for IVT-mRNA performance, while 5'-end modifications had modest effects on mRNA expression and immune responses.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Materials Science, Multidisciplinary
Magdalena Mazurek-Budzynska, Marc Behl, Richard Neumann, Andreas Lendlein
Summary: This study presents multifunctional 4D actuators processed by 3D-printing, with actuator functionality integrated into the shaped body. The materials are based on crosslinked poly(carbonate-urea-urethane) networks (PCUU) synthesized in an integrated process, showing reversible deformation when thermomechanically programmed.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maryam Madani, Sedigheh Borandeh, Arun Kumar Teoti, Jukka V. Seppala
Summary: Due to increasing public concern over hygiene, this study focuses on developing biobased virucidal/virus capture agents by modifying the surface of cellulose nanocrystals (CNCs) with positively charged functional groups. The direct and indirect cationization of CNCs leads to biobased agents with immobilized cationic charge, showing good virus capture activity. These agents have potential applications in various fields including textiles, packaging, and wastewater treatment.
Article
Nanoscience & Nanotechnology
Arun Teotia, Isabella Lauren, Sedigheh Borandeh, Jukka Seppala
Summary: Cationic polysaccharides, specifically quaternary chitosans (QCs), have shown significant antimicrobial properties and can be potential antiviral agents. This study aimed to develop metal-free and environmentally friendly QCs with long-lasting virucidal activity. The influence of quaternary functional group, charge density, and molecular weight on the antiviral properties of QCs was investigated. The findings demonstrated that heterogeneously functionalized chitosan derivatives exhibited excellent antiviral activity and have promising potential in various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Hossein Baniasadi, Zahra Madani, Mithila Mohan, Maija Vaara, Sami Lipponen, Jaana Vapaavuori, Jukka V. Seppala
Summary: This study introduces the development of a thermally responsive shape-morphing fabric using low-melting-point polyamide shape memory actuators. Homogeneous dispersion of compatibilized starch particles into the matrix is achieved, resulting in composites with excellent mechanical properties. The composites exhibit remarkable shape recovery properties, making them suitable for designing heat-responsive textiles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Shazia Shaikh, Hossein Baniasadi, Shreya Mehrotra, Rupita Ghosh, Prerna Singh, Jukka V. Seppala, Ashok Kumar
Summary: This study focuses on addressing the limitations of traditional metal-alloy bone fixation devices by fabricating biodegradable composites using poly(lactic acid) (PLA) and strontium-substituted nanohydroxyapatite (SrHAP). The composites demonstrate improved mechanical properties, formability, and radiopacity, making them suitable as implant materials for orthopedic applications.
Article
Biochemistry & Molecular Biology
Bas van Bochove, Jan J. Rongen, Gerjon Hannink, Jukka V. Seppala, Andre A. Poot, Dirk W. Grijpma
Summary: PTMC and P(TMC-co-ε-CL) networks prepared by photo-crosslinking have slow degradation properties, and the degradation rate can be adjusted by varying the TMC:ε-CL ratio.
MACROMOLECULAR BIOSCIENCE
(2023)
