Article
Medicine, General & Internal
Kristian Nzogang Fomo, Carsten Schmelter, Joshua Atta, Vanessa M. Beutgen, Rebecca Schwarz, Natarajan Perumal, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. Grus
Summary: This study demonstrates that synthetic CDR2 peptide increases the viability of RGCs in vitro in a concentration-dependent manner and exhibits high affinity towards the retinal target protein HIST1H3A. Quantitative mass spectrometry analysis reveals significant effects of CDR2 peptide on 39 proteins, promoting up-regulation of proteins involved in energy production and the regulatory ubiquitin proteasome system.
FRONTIERS IN MEDICINE
(2022)
Review
Cell Biology
Bushra Riaz, Seonghyang Sohn
Summary: Inflammatory diseases are characterized by a lack of self-tolerance and involve aberrant immune responses. Neutrophils play a significant role in innate immunity, but also contribute to the progression of diseases by causing tissue destruction. The heterogeneity of neutrophil function has adverse effects on inflammatory diseases, and their role in these diseases is complex and not well understood. Neutrophils are considered an intriguing target for therapeutic interventions, and various approaches are being developed to improve neutrophil function.
Review
Biochemistry & Molecular Biology
Vincenzo Giuseppe Nicoletti, Krisztian Pajer, Damiano Calcagno, Gholam Pajenda, Antal Nogradi
Summary: Mature neurotrophic factors and their propeptides are crucial in regulating neuronal growth, survival, and recovery. Understanding the mechanisms of these factors offers potential for neuroregenerative medicine.
Article
Cell Biology
Inmaculada Martos-Folgado, Alberto del Monte-Monge, Cristina Lorenzo, Christian E. Busse, Pilar Delgado, Sonia M. Mur, Laura Cobos-Figueroa, Joan C. Escola-Gil, Jose L. Martin-Ventura, Hedda Wardemann, Almudena R. Ramiro
Summary: Immunization with MDA-LDL in mice can induce antibody responses, promote germinal center antibody responses, and prevent atherosclerosis. Chimeric animals lacking germinal center plasma cells show accelerated atherosclerosis.
Article
Food Science & Technology
Jian Ren, Sijin Li, Chunli Song, Xiaohong Sun, Xiaolan Liu
Summary: This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice, possibly attributed to the antioxidant and anti-inflammatory activities of BSPs.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Neurosciences
Yuanyuan Li, Amanda Tran, Lori Graham, John Brock, Mark H. Tuszynski, Paul Lu
Summary: Providing trophic gradients caudal to the spinal cord injury can enhance and guide the growth of neural stem cell axons, improving neural relay formation and functional outcomes.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Hongyan Lu, Li Fang, Xiyan Wang, Dan Wu, Chunlei Liu, Xiaoting Liu, Ji Wang, Yawen Gao, Weihong Min
Summary: This study investigated the structure-activity relationship of pine nut antioxidant peptide WYPGK and its derivative peptides, and evaluated their protective effect on mitochondrial structure and function. The results showed that the derivative peptide WYSGK exhibited higher antioxidant activity and reduced oxidative stress-induced cell damage. These findings suggest that studying the structure-activity relationship of peptides can lead to the development of functional factors.
Article
Chemistry, Multidisciplinary
Motoharu Hirano, Hidetomo Yokoo, Chihiro Goto, Makoto Oba, Takashi Misawa, Yosuke Demizu
Summary: We have developed cell-penetrating stapled peptides based on the amphipathic antimicrobial peptide magainin 2 for efficient intracellular delivery of nucleic acids including pDNA, mRNA, and siRNA. The peptide st7-5_R can form stable complexes with these nucleic acids and efficiently deliver them into cells.
Article
Multidisciplinary Sciences
Panetha Pansri, Phetcharat Phanthong, Nopparat Suthprasertporn, Yindee Kitiyanant, Alisa Tubsuwan, Andras Dinnyes, Julianna Kobolak, Narisorn Kitiyanant
Summary: The study found that BDNF can promote cell proliferation of AD-derived hNPCs, but does not have a promoting effect on neurite outgrowth. The JAK2 inhibitor AG490 partially decreased BDNF-induced cell proliferation.
Article
Microbiology
Maureen Kleinhenz, Pavani Beesetty, Ching Yang, Zhaotao Li, Christopher P. Montgomery
Summary: Recurrent Staphylococcus aureus infections are common, but no approved vaccine is available. Antibiotic therapy resolves infection but fails to elicit protective immunity. Combined vaccination and antibiotics can treat infection and generate durable protective immunity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Shigeru Katayama, Henry M. Corpuz, Soichiro Nakamura
Summary: There is a growing demand for functional foods to reduce the risk of age-related cognitive impairment, dementia, and Alzheimer's disease, with plant-derived bioactive compounds showing potential in improving memory and cognitive functions. Studies have focused on the characteristics and structure-activity relationships of memory-enhancing peptides, emphasizing the importance of understanding their bioavailability and permeability through the blood-brain barrier as potential neurological treatment options. This review highlights the memory-enhancing effects of plant-derived peptides and their structure-activity relationships, with a focus on blood-brain barrier permeability.
Article
Infectious Diseases
Junyuan Luo, Zening Feng, Xiaohui Lyu, Linglin Zhang
Summary: This study investigated the effects of LF-1, a lactotransferrin-derived antimicrobial peptide, on the cariogenic virulence factors of Streptococcus mutans. LF-1 inhibited the growth and key enzymatic activity of S. mutans, as well as downregulated virulence-associated gene expression. These findings suggest that LF-1 has promising application prospects in combating S. mutans and dental caries.
Article
Biochemistry & Molecular Biology
Emerenziana Ottaviano, Elisa Borghi, Laura Giovati, Monica Falleni, Delfina Tosi, Walter Magliani, Giulia Morace, Stefania Conti, Tecla Ciociola
Summary: The synthetic peptide F11A showed significant candidacidal activity in vitro and improved survival in Galleria mellonella larvae infected with Candida albicans by modulating the host immune system and enhancing antifungal capabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Elisa Garcia, Jorge Aguilar-Cevallos, Raul Silva-Garcia, Antonio Ibarra
MEDIATORS OF INFLAMMATION
(2016)
Article
Pharmacology & Pharmacy
Susana Barbosa-Mendez, Noe Jurado, Maura Matus-Ortega, Susana Martinon, Gerardo Heinze, Alberto Salazar-Juarez
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Elisa Garcia, Raul Silva-Garcia, Adrian Flores-Romero, Liliana Blancas-Espinoza, Roxana Rodriguez-Barrera, Antonio Ibarra
JOURNAL OF MOLECULAR NEUROSCIENCE
(2018)
Article
Cell Biology
Yolanda Cruz, Edna E. Garcia, Jessica Galvez, Stella Arias-Santiago, Horatio G. Carvajal, Raul Silva-Garcia, Herlinda Bonilla-Jaime, Julio Rojas-Castaneda, Antonio Ibarra
NEURAL REGENERATION RESEARCH
(2018)
Article
Multidisciplinary Sciences
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa Garcia-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez Ospina, Laura Castillo-Carvajal, Esperanza Melendez-Herrera, Antonio Ibarra
Article
Neurosciences
Antonio Ibarra, Erika Mendieta-Arbesu, Paola Suarez-Meade, Elisa Garcia-Vences, Susana Martinon, Roxana Rodriguez-Barrera, Joel Lome, Adrian Flores-Romero, Raul Silva-Garcia, Vinnitsa Buzoianu-Anguiano, Cesar Borlongan, Tamara D. Frydman
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2019)
Review
Immunology
Susana Martinon, Angel Cisneros, Sergio Villicana, Ricardo Hernandez-Miramontes, Edgar Mixcoha, Psyche Calderon-Vargas
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Neurosciences
Roxana Rodriguez-Barrera, Adrian Flores-Romero, Elisa Garcia, Ana Maria Fernandez-Presas, Diego Incontri-Abraham, Lisset Navarro-Torres, Julian Garcia-Sanchez, Juan Jose Juarez-Vignon Whaley, Ignacio Madrazo, Antonio Ibarra
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Clinical Neurology
Vinnitsa Buzoianu-Anguiano, Jared Rivera-Osorio, Sandra Orozco-Suarez, Angelica Vega-Garcia, Elisa Garcia-Vences, Stephanie Sanchez-Torres, Ismael Jimenez-Estrada, Gabriel Guizar-Sahagun, Jose Mondragon-Caso, Francisca Fernandez-Valverde, Ignacio Madrazo, Israel Grijalva
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Roxana Rodriguez-Barrera, Adrian Flores-Romero, Vinnitsa Buzoianu-Anguiano, Elisa Garcia, Karla Soria-Zavala, Diego Incontri-Abraham, Marcela Garibay-Lopez, Juan Jose Juarez-Vignon Whaley, Antonio Ibarra
FRONTIERS IN NEUROLOGY
(2020)
Article
Cell Biology
Elisa Garcia, Roxana Rodriguez-Barrera, Vinnitsa Buzoianu-Anguiano, Adrian Flores-Romero, Emanuel Malagon-Axotla, Marco Guerrero-Godinee, Estefania De la Cruz-Castillo, Laura Castillo-Carvajal, Monserrat Rivas-Gonzalez, Paola Santiago-Tovar, Ivis Morales, Cesar Borlongan, Antonio Ibarra
NEURAL REGENERATION RESEARCH
(2019)
Article
Neurosciences
Roxana Rodriguez-Barrera, Adrian Flores-Romero, Ana Maria Fernandez-Presas, Elisa Garcia-Vences, Raul Silva-Garcia, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suarez-Meade, Antonio Ibarra