Review
Biochemistry & Molecular Biology
Rosaria Meccariello, Stefania D'Angelo
Summary: Polyphenol intake has beneficial effects on improving insulin resistance and related diabetes risk factors, slowing down the aging process. Polyphenols are effective in ameliorating oxidative stress, inflammation, impaired proteostasis, and cellular senescence, all of which are age-related phenotypes.
Review
Biochemistry & Molecular Biology
Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim, Kyu-Jae Lee
Summary: Age-related diseases pose a significant risk to public health, and molecular hydrogen (H-2) has shown potential as an antioxidant and anti-inflammatory agent for treating various oxidative stress and aging-related diseases. This review focuses on the therapeutic role of H-2 in neurological diseases.
Article
Biochemistry & Molecular Biology
Maria Cristina Polidori, Patrizia Mecocci
Summary: This review explores the role of oxidative stress in aging and frailty, highlighting the need for effective management strategies to prevent and address frailty.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Genetics & Heredity
Angelica Dominguez-de-Barros, Ines Sifaoui, Zuzanna Borecka, Roberto Dorta-Guerra, Jacob Lorenzo-Morales, Rafael Castro-Fuentes, Elizabeth Cordoba-Lanus
Summary: This study found that telomeres shorten with age in Psittacidae species and that short-lived birds accumulate more oxidative stress products but have lower antioxidant capacity compared to long-lived birds. Breeding is also related to telomere shortening, with short-lived birds experiencing increased oxidative damage during breeding while long-lived birds are able to counteract this damage with increased antioxidant capacity.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Hadi Tabarraei, Brandon M. Waddell, Kelly Raymond, Sydney M. Murray, Ying Wang, Keith P. Choe, Cheng-Wei Wu
Summary: CCR4-NOT is a versatile eukaryotic protein complex that regulates gene expression at multiple steps. This study shows that a subunit of CCR4-NOT, ccf-1, is required for the transcriptional response to cadmium and acrylamide stress in C. elegans. Knockdown of ccf-1 attenuates the activation of stress-protective genes, leading to decreased stress resistance and lifespan in C. elegans.
Review
Cell Biology
Ashish Kumar, Kavitha Thirumurugan
Summary: Normal somatic cells undergo finite cellular divisions, but they can be arrested in response to various stressors such as oxidative stress, oncogene-induced abnormalities, genotoxic stress, and telomere attrition. Repair mechanisms are activated during the cell cycle pause caused by stress, and the nature of the stress determines whether repair or permanent arrest occurs. Quiescence allows damaged cells to repair and return to the cell cycle, while senescence is irreversible and leads to age-related disorders.
Article
Biology
Alexander M. Shephard, Amanda K. Hund, Emilie C. Snell-Rood
Summary: Life-history theory predicts a trade-off between investment in reproduction traits and survival or longevity. This study found that individuals can respond to metabolic stress by increasing cellular maintenance responses, which may increase longevity at a cost to reproductive investment.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro, Junji Yodoi
Summary: Epithelial cells in the respiratory system are directly exposed to exogenous ROS, increasing the risk of oxidative stress; Dysfunction of redox regulation due to cellular aging accelerates COPD pathogenesis; Drugs targeting oxidative stress pathways can help precisely regulate the redox system.
Article
Cell Biology
Jessica M. Hoffman, Teresa G. Valencak
Summary: Women live longer than men globally, with the role of brown adipose tissue potentially contributing to this longevity advantage in females. Understanding the thermogenesis-metabolism nexus and sex differences in these factors may play a significant role in explaining the female longevity bias seen in human populations.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Pongrapee Laorodphun, Rada Cherngwelling, Aussara Panya, Phatchawan Arjinajarn
Summary: The study demonstrated that pre-treatment with CUR could alleviate GM-induced nephrotoxicity in rats by restoring kidney function and reducing oxidative stress, as evidenced by decreased levels of creatinine and blood urea nitrogen, increased creatinine clearance, and normalized expression of antioxidant and ER stress markers. CUR's antioxidative properties also contributed to the reduction in ER stress and apoptotic protein biomarkers in the kidney. These findings suggest that CUR could be a potential supplement for preventing nephrotoxicity and other kidney diseases in the future.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shawna Hubert, Giridhar Athrey
Summary: The study reveals that fast-growing chicken breeds exhibit mitochondrial dysfunction and reduced oxidative phosphorylation compared to slow-growing heritage breeds. The decline in oxidative phosphorylation performance is more pronounced in young fast-growing broilers, further worsening by 42 days.
Article
Food Science & Technology
Yannan Chen, Siyuan Fei, Xiaoting Yu, Mingqian Tan
Summary: Dandelion extract (DE) has shown excellent antioxidant properties and is being extensively studied in the fields of food and medicine. This study investigates the effects of DE on H2O2-induced oxidative damage and reveals that DE can alleviate cell damage, reduce reactive oxygen species levels, and restore normal metabolic function. These findings provide valuable insights into the mechanism of DE and suggest its potential as an additive for functional food products.
Article
Horticulture
Cheng Song, Muhammad Aamir Manzoor, Di Mao, Xiang Ren, Wenwu Zhang, Yingyu Zhang
Summary: This study found that the application of melatonin significantly enhanced various aspects of tomato plant growth and reduced the damage caused by cadmium stress. By increasing the activity of antioxidant enzymes and decreasing the levels of oxidative stress markers, melatonin improved the resistance of tomato plants to cadmium stress.
SCIENTIA HORTICULTURAE
(2024)
Article
Biochemistry & Molecular Biology
Kunanya Masodsai, Yi-Yuan Lin, Sih-Yin Lin, Chia-Ting Su, Shin-Da Lee, Ai-Lun Yang
Summary: This study revealed that aging has an additive effect on insulin- and IGF-1-mediated endothelial dysfunction in SHRs, partly due to reduced NO production and antioxidant deficiency.
Article
Physiology
Alejandra D. Campoy-Diaz, Gabriela Malanga, Maximiliano Giraud-Billoud, Israel A. Vega
Summary: This study aimed to investigate the balance between the production of free radicals and antioxidant defenses, and the generation of oxidative damage in the digestive gland of Pomacea canaliculata after exposure to mercury, arsenic, and uranium. The results showed that these toxic elements caused oxidative damage in the mollusk, but it was partially compensated by non-enzymatic antioxidant defenses. This study provides insights into the cellular mechanisms involved in the tolerance of this species to non-essential elements and confirms its potential as a bioindicator species for metal pollution in freshwater bodies.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jean-Francois Le Galliard, David Rozen-Rechels, Anjelica Lecomte, Clemence Demay, Andreaz Dupoue, Sandrine Meylan
Summary: Thermoregulation is crucial for ectotherms to maintain their body temperature close to an optimum level for ecological performance. Short-term dehydration can weakly influence thermal preferences in some species, with environmental humidity conditions being important methodological factors to consider in the analysis of thermal preferences.
Article
Ecology
Mathias Dezetter, Andreaz Dupoue, Jean-Francois Le Galliard, Olivier Lourdais
Summary: The study reveals that individuals affected by thermal conditions during the juvenile life stage show changes in metabolic rate and water loss persisting until adulthood, indicating the flexibility of long-lived organisms in adapting to climate change. The research also suggests that physiological syndromes in individuals could play a role in their response to climate change alongside plasticity.
FUNCTIONAL ECOLOGY
(2022)
Article
Ecology
Josefa Bleu, Sandrine Meylan, Jean Clobert, Manuel Massot
Summary: Grandmaternal age at reproduction can affect the characteristics, survival, and reproductive performance of grandoffspring in wild populations, independent of maternal age.
FUNCTIONAL ECOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexis Y. Dollion, Sandrine Meylan, Olivier Marquis, Mathieu Leroux-Coyau, Anthony Herrel
Summary: In many animals, males use color signals to convey information and mitigate harmful interactions. However, the ability to change color in this context has not received much attention. In this study, male panther chameleons were found to exhibit specific color changes in the visible spectrum during intrasexual agonistic interactions. These color changes play a prominent role in communication, while UV coloration does not seem to be involved in these interactions.
Article
Biology
Mathias Dezetter, Jean-Francois Le Galliard, Mathieu Leroux-Coyau, Francois Brischoux, Frederic Angelier, Olivier Lourdais
Summary: Heatwaves and droughts, which are becoming more intense and frequent due to climate change, can have additive effects on the physiological stress and behavioral responses of organisms. This study experimentally investigated the combined impacts of simulated heatwave and drought on the asp viper. The results showed that the combination of heatwave and water deprivation exacerbated physiological stress and influenced dehydration behaviors.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Ecology
Arnaud Badiane, Andreaz Dupoue, Pauline Blaimont, Donald B. Miles, Anthony L. Gilbert, Mathieu Leroux-Coyau, Anna Kawamoto, David Rozen-Rechels, Sandrine Meylan, Jean Clobert, Jean-Francois Le Galliard
Summary: The study found that the three color signals conveyed information on different aspects of male condition, supporting a multiple message hypothesis. Testosterone only influenced parasitism, suggesting that it does not directly mediate the relationships between color signals and their information content. Additionally, color signals became more saturated in forested habitats, indicating an adaptation to degraded light conditions, and generally brighter in mesic conditions, contradicting the thermal melanism hypothesis.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Physiology
Yann Voituron, Damien Roussel, Jean-Francois Le Galliard, Andreaz Dupoue, Caroline Romestaing, Sandrine Meylan
Summary: This study examines the effects of stress on metabolism and mitochondrial functionality in lizards using the application of corticosterone. The results show that while skeletal muscle is not impacted, there is a time-dependent regulation of liver mitochondrial functionality under stress. The study also reveals the response mechanism of mitochondria to energy demands.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Andreaz Dupoue, Pauline Blaimont, Frederic Angelier, Cecile Ribout, David Rozen-Rechels, Murielle Richard, Donald Miles, Pierre de Villemereuil, Alexis Rutschmann, Arnaud Badiane, Fabien Aubret, Olivier Lourdais, Sandrine Meylan, Julien Cote, Jean Clobert, Jean-Francois Le Galliarde
Summary: This study investigated the relationship between life history, telomere length (TL), and extinction risk in a cold-adapted ectotherm (Zootoca vivipara) facing climate-induced extirpations. The results suggest intergenerational accumulation of accelerated aging rate in declining populations, with most neonates inheriting short telomeres and unlikely to reach recruitment. TL also explained females' reproductive performance at adulthood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Beth A. Reinke, Hugo Cayuela, Fredric J. Janzen, Jean-Francois Lemaitre, Jean-Michel Gaillard, A. Michelle Lawing, John B. Iverson, Ditte G. Christiansen, Inigo Martinez-Solano, Gregorio Sanchez-Montes, Jorge Gutierrez-Rodriguez, Francis L. Rose, Nicola Nelson, Susan Keall, Alain J. Crivelli, Theodoros Nazirides, Annegret Grimm-Seyfarth, Klaus Henle, Emiliano Mori, Gaetan Guiller, Rebecca Homan, Anthony Olivier, Erin Muths, Blake R. Hossack, Xavier Bonnet, David S. Pilliod, Marieke Lettink, Tony Whitaker, Benedikt R. Schmidt, Michael G. Gardner, Marc Cheylan, Francoise Poitevin, Ana Golubovic, Ljiljana Tomovic, Dragan Arsovski, Richard A. Griffiths, Jan W. Arntzen, Jean-Pierre Baron, Jean-Francois Le Galliard, Thomas Tully, Luca Luiselli, Massimo Capula, Lorenzo Rugiero, Rebecca McCaffery, Lisa A. Eby, Venetia Briggs-Gonzalez, Frank Mazzotti, David Pearson, Brad A. Lambert, David M. Green, Nathalie Jreidini, Claudio Angelini, Graham Pyke, Jean-Marc Thirion, Pierre Joly, Jean-Paul Lena, Anton D. Tucker, Col Limpus, Pauline Priol, Aurelien Besnard, Pauline Bernard, Kristin Stanford, Richard King, Justin Garwood, Jaime Bosch, Franco L. Souza, Jaime Bertoluci, Shirley Famelli, Kurt Grossenbacher, Omar Lenzi, Kathleen Matthews, Sylvain Boitaud, Deanna H. Olson, Tim S. Jessop, Graeme R. Gillespie, Jean Clobert, Murielle Richard, Andres Valenzuela-Sanchez, Gary M. Fellers, Patrick M. Kleeman, Brian J. Halstead, Evan H. Campbell Grant, Phillip G. Byrne, Thierry Fretey, Bernard Le Garff, Pauline Levionnois, John C. Maerz, Julian Pichenot, Kurtulus Olgun, Nazan Uzum, Aziz Avci, Claude Miaud, Johan Elmberg, Gregory P. Brown, Richard Shine, Nathan F. Bendik, Lisa O'Donnell, Courtney L. Davis, Michael J. Lannoo, Rochelle M. Stiles, Robert M. Cox, Aaron M. Reedy, Daniel A. Warner, Eric Bonnaire, Kristine Grayson, Roberto Ramos-Targarona, Eyup Baskale, David Munoz, John Measey, F. Andre de Villiers, Will Selman, Victor Ronget, Anne M. Bronikowski, David A. W. Miller
Summary: This study investigates the aging rates and longevity of wild ectothermic tetrapods, showing that they exhibit higher diversity of aging rates compared to endotherms and provide evidence of negligible aging. Protective phenotypes and life-history strategies explain the macroevolutionary patterns of aging.
Article
Evolutionary Biology
Chloe Chabaud, Matthieu Berroneau, Maud Berroneau, Andreaz Dupoue, Michael Guillon, Robin Viton, Rodrigo S. B. Gavira, Jean Clobert, Olivier Lourdais, Jean-Francois Le Galliard
Summary: Thermo-hydroregulation strategies play a key role in determining life-history traits of terrestrial ectotherms. This study on European common lizards found that rainfall and habitat features have a greater impact on geographical variations in morphology and physiology than thermal conditions.
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2022)
Article
Ecology
George A. Brusch, Jean-Francois Le Galliard, Robin Viton, Rodrigo S. B. Gavira, Jean Clobert, Olivier Lourdais
Summary: Climate change and altered rainfall patterns disrupt water availability for species adapted to cold and wet environments. This study found that higher day or night temperatures decrease gestation length and increase energetic demands in common lizards. High nighttime temperatures can burden pregnant mothers already facing resource limitations, potentially explaining declines in warm-margin populations.
Article
Ecology
Mathias Dezetter, Jean-Francois Le Galliard, Olivier Lourdais
Summary: During extreme climate events, ectotherms may use behavioral thermoregulation to buffer thermal stress. However, the effect of behavioral thermoregulation on dehydration risks remains largely unknown. In this study, we investigated the response of asp vipers to changes in air and microhabitat humidity during a simulated heatwave and water deprivation. Our results show that dry air conditions led to physiological dehydration and muscle wasting, but vipers were able to mitigate these effects by selecting a shelter with a moist microclimate. This study provides experimental evidence that active behavioral hydroregulation can alleviate the physiological stress caused by dry spells in ectotherms.
Article
Biology
Chloe Chabaud, George A. Brusch, Anouk Pellerin, Olivier Lourdais, Jean-Francois Le Galliard
Summary: Terrestrial animals have developed strategies to cope with limited drinking water availability, including maintaining hydration through dietary water intake. However, a study on common lizards suggests that they primarily depend on drinking water rather than improving hydration through prey consumption. Consumption of high-quality prey can reduce the energy costs of water deprivation.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)