A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease
出版年份 2016 全文链接
标题
A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease
作者
关键词
Alzheimer’s disease, Parkinson’s disease, Disease progression, Biomarkers, Disease progression, Clinical trials, Neuroprotective agents
出版物
BMC Neurology
Volume 16, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-06-16
DOI
10.1186/s12883-016-0606-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
- (2015) LANCET NEUROLOGY
- A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
- (2014) Eric Karran et al. ANNALS OF NEUROLOGY
- Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease
- (2014) D. McGhee et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- A Systematic Review of Biomarkers for Disease Progression in Alzheimer's Disease
- (2014) David J. M. McGhee et al. PLoS One
- Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson Disease
- (2014) Michael A. Schwarzschild et al. JAMA Neurology
- A systematic review of biomarkers for disease progression in Parkinson’s disease
- (2013) David JM McGhee et al. BMC Neurology
- Exenatide and the treatment of patients with Parkinson’s disease
- (2013) Iciar Aviles-Olmos et al. JOURNAL OF CLINICAL INVESTIGATION
- Chronic Divalproex Sodium to Attenuate Agitation and Clinical Progression of Alzheimer Disease
- (2011) Pierre N. Tariot ARCHIVES OF GENERAL PSYCHIATRY
- Designing clinical trials to test disease-modifying agents: application to the treatment trials of Alzheimer’s disease
- (2011) Chengjie Xiong et al. Clinical Trials
- Defining meaningful outcome measures in trials of disease-modifying therapies in Parkinson's disease
- (2011) Jonathan R Evans et al. EXPERT OPINION ON PHARMACOTHERAPY
- The delayed-start study in Parkinson disease: Can't satisfy everyone
- (2010) C. W. Olanow et al. NEUROLOGY
- Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial
- (2009) Robert C. Green JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Neuroprotection trials in Parkinson's disease: Systematic review
- (2009) Robert G. Hart et al. MOVEMENT DISORDERS
- "Disease-modification" trials in Parkinson disease: Target populations, endpoints and study design
- (2009) O. Rascol NEUROLOGY
- The Delayed-Start Study Design
- (2009) Ralph B. D'Agostino NEW ENGLAND JOURNAL OF MEDICINE
- A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease
- (2009) C. Warren Olanow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Are delayed-start design trials to show neuroprotection in Parkinson's disease fundamentally flawed?
- (2008) Carl E. Clarke MOVEMENT DISORDERS
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started