期刊
BIOESSAYS
卷 42, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/bies.201900186
关键词
brain ventricles; cerebrospinal fluid; choroid plexus; epithelial relaxation; neural tube; neuroepithelium; neurological diseases
资金
- BECAS Chile Funding Source: Medline
- Lorraine & and Emanuel Balkin [IOS-1258087] Funding Source: Medline
The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据