期刊
BIOESSAYS
卷 42, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/bies.201900232
关键词
chromatin organization; endogenous retroviruses; LINE1; mutagenesis; preimplantation development; transposable elements; transposons
资金
- UK Medical Research Council
- UKRI Future Leaders Fellowship
- Canada 150 Research Chair in Developmental Epigenetics
- USA National Institutes of Health [R01 GM123556]
- Canadian Institutes of Health Research
- Sinai Health Foundation
- Medicine by Design Program of the University of Toronto
- MRC [MC_UP_1605/4] Funding Source: UKRI
- UKRI [MC_EX_MR/S015930/1] Funding Source: UKRI
Transposable elements (TEs) are sequences currently or historically mobile, and are present across all eukaryotic genomes. A growing interest in understanding the regulation and function of TEs has revealed seemingly dichotomous roles for these elements in evolution, development, and disease. On the one hand, many gene regulatory networks owe their organization to the spread of cis-elements and DNA binding sites through TE mobilization during evolution. On the other hand, the uncontrolled activity of transposons can generate mutations and contribute to disease, including cancer, while their increased expression may also trigger immune pathways that result in inflammation or senescence. Interestingly, TEs have recently been found to have novel essential functions during mammalian development. Here, the function and regulation of TEs are discussed, with a focus on LINE1 in mammals. It is proposed that LINE1 is a beneficial endogenous dual regulator of gene expression and genomic diversity during mammalian development, and that both of these functions may be detrimental if deregulated in disease contexts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据