Review
Cell & Tissue Engineering
Yan Hu, Xiao Chen, Sicheng Wang, Yingying Jing, Jiacan Su
Summary: Osteoarthritis is a joint disorder characterized by cartilage degeneration and pain, with increasing global incidence due to aging and obesity trends. Research on the role of subchondral bone in osteoarthritis initiation and progression is crucial for understanding and treating the disease.
Review
Cell & Tissue Engineering
P. Luo, Q. Yuan, M. Yang, X. Wan, P. Xu
Summary: Osteoarthritis (OA) is a degenerative joint disease caused by various factors, including ageing, strain, trauma, and congenital joint abnormalities. Changes in the subchondral bone (SB) not only serve as secondary manifestations of OA, but also actively contribute to the severity of the disease. Different stages of OA result in microstructural alterations in the SB, and osteocytes, osteoblasts, and osteoclasts play crucial roles in the pathogenesis of OA. Understanding these changes in SB provides insights for developing new treatment approaches for OA.
BONE & JOINT RESEARCH
(2023)
Review
Endocrinology & Metabolism
Shihua Zhang, Tingting Li, Yao Feng, Keping Zhang, Jun Zou, Xiquan Weng, Yu Yuan, Lan Zhang
Summary: Articular cartilage degeneration causes various joint diseases, with osteoarthritis being the most typical. Osteoarthritis is characterized by cartilage degeneration and persistent pain, impacting patient's quality of life and placing a burden on society. The occurrence and development of osteoarthritis is connected to subchondral bone microenvironment disorder. Exercise can improve the subchondral bone microenvironment, but the specific mechanism remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Environmental
Zhen Geng, Xiaogang Wang, Yuanman Yu, Luli Ji, Jing Wang, Changsheng Liu
Summary: The study developed a pH-responsive NP-BP system that effectively inhibits osteoclastic bone resorption and subchondral bone abnormal remodeling, showing potential applications for early OA treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Rheumatology
Wenhui Hu, Yueqi Chen, Ce Dou, Shiwu Dong
Summary: This article discusses the changes in subchondral bone during OA progression and potential strategies for treating OA, including restoring abnormal remodeling and blocking blood vessels, highlighting the relationship between the subchondral bone microenvironment and OA pain.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Cell & Tissue Engineering
Jun Ying, Pinger Wang, Zhenyu Shi, Jianbo Xu, Qinwen Ge, Qi Sun, Weidong Wang, Ju Li, Chengliang Wu, Peijian Tong, Hongting Jin
Summary: Osteoarthritis (OA) is a joint disease that affects both articular cartilage and subchondral bone. The association between metabolic syndrome and OA, specifically glucose metabolism, has been recently recognized. The role of glucose metabolism in subchondral bone sclerosis during OA pathogenesis is still largely unknown.
Article
Biochemistry & Molecular Biology
Hongzhi Ding, Huan Ding, Pei Mu, Xiongwei Lu, Zhixing Xu
Summary: Osteoarthritis (OA) is a degenerative disease characterized by cartilage destruction, bone remodeling, osteophyte formation, and synovitis. Maintaining the integrity of subchondral bone is essential for preventing and treating OA. Diosmetin, a natural flavonoid, has shown potential in suppressing subchondral bone loss and cartilage degradation associated with OA.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Wang Yajun, Cui Jin, Gu Zhengrong, Fang Chao, Hu Yan, Weng Weizong, Li Xiaoqun, Zhou Qirong, Chen Huiwen, Zhang Hao, Guo Jiawei, Zhuang Xinchen, Sheng Shihao, Wang Sicheng, Chen Xiao, Su Jiacan
Summary: Betaine attenuated OA progression by inhibiting hyperactivated osteoclastogenesis and maintaining microarchitecture in subchondral bone. Additionally, betaine could reorganize the structure of subchondral bone and inhibit abnormal angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Michael Morgan, Jenny Thai, Vida Nazemian, Richard Song, Jason J. Ivanusic
Summary: This study explored the role of innervation of knee joint articular tissues and surrounding bone in osteoarthritis (OA) pain. The findings suggest that early OA pain is driven by nerves that innervate the joint capsule, while late OA pain involves the recruitment of nerves that innervate the subchondral bone. These results highlight the importance of targeting bone innervation for the development of mechanism-based therapies for late OA pain.
Review
Medicine, General & Internal
Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli, Giustino Varrassi
Summary: In recent years, there have been interesting advancements in the understanding of the basis of osteoarthritis (OA). Research suggests that cartilage degeneration is preceded by subchondral bone lesions, indicating a key role of this mechanism in the pathogenesis and progression of OA. Chronic low-grade inflammation of the synovial lining, along with immunological and metabolic factors, is now considered crucial in driving inflammation and tissue destruction in OA. Additionally, the role of neuroinflammation and central sensitization mechanisms as underlying causes of chronic pain has been characterized.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kelei Wang, Xuanyuan Lu, Xinyu Li, Yufeng Zhang, Rongjian Xu, Yun Lou, Yanben Wang, Tan Zhang, Yu Qian
Summary: This study demonstrates the dual protective effects of velutin against cartilage degradation and subchondral bone loss in osteoarthritis (OA) by inhibiting the p38 signaling pathway. Velutin is considered as an alternative treatment for OA due to its anti-inflammatory properties.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Yiming Zhong, Yiming Xu, Song Xue, Libo Zhu, Haiming Lu, Cong Wang, Hongjie Chen, Weilin Sang, Jinzhong Ma
Summary: This study suggests that nangibotide may have a protective effect on the bone-cartilage unit and could be an alternative treatment option for osteoarthritis.
INFLAMMOPHARMACOLOGY
(2022)
Review
Biology
Hope C. Ball, Andrew L. Alejo, Trinity K. Samson, Amanda M. Alejo, Fayez F. Safadi
Summary: This review provides an updated overview of the epigenetic factors involved in osteoarthritis, discussing their impact on the onset and development of the disease, and exploring current therapeutic options targeting aberrant epigenetic regulation.
Article
Cell & Tissue Engineering
N. Angrisani, R. Willumeit-Roemer, H. Windhagen, B. Mavila Chathoth, V. Scheper, B. Wiese, H. Helmholz, J. Reifenrath
Summary: The study found that implanting magnesium cylinders had an influence on the subchondral bone quality of osteoarthritic rabbits, increasing bone volume and reducing cartilage lesions. Further evaluations with different time points and alloys will determine if this can alter osteoarthritis progression.
EUROPEAN CELLS & MATERIALS
(2021)
Review
Cell Biology
Xiaobo Zhu, Yau Tsz Chan, Patrick S. H. Yung, Rocky S. Tuan, Yangzi Jiang
Summary: This review discusses the cellular and molecular mechanisms of subchondral bone remodeling in relation to osteoarthritis, as well as potential therapeutic targets and interventions for this process. It also outlines candidate treatments for subchondral bone remodeling in OA, including the use of bone-acting reagents and regenerative therapies, based on current clinical therapies and responses in subchondral bone remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
X. Wu, C. Liyanage, M. Plan, T. Stark, T. McCubbin, R. A. Barrero, J. Batra, R. Crawford, Y. Xiao, I. Prasadam
Summary: This study aims to identify the changes in energy metabolism in osteoarthritis (OA) cartilage. Metabolomics, proteomics, and transcriptomics analyses were conducted to investigate the global alterations in OA metabolism. The results showed increased lactate production and decreased mitochondrial respiratory rates in OA chondrocytes. This study provides a basis for targeting metabolism as a therapeutic approach for OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Engineering, Biomedical
Jeffrey J. Raj, Matt Thompson, Sarah L. Whitehouse, Anjali Jaiprakash, Ibin Varughese, Ross W. Crawford
Summary: Standard practice in total hip arthroplasty is to medialise the acetabular component, but downsizing and minimizing medialisation can preserve bone volume and reduce resected bone volume by at least 35%. For example, downsizing the acetabular component by one size preserves between 2.6 cm(3) and 8.4 cm(3) of bone volume, while reducing medialisation by 3 mm reduces bone loss by 5.9 cm(3) - 44% less bone volume resection. This preservation of bone can benefit future revision surgeries, and surgeons should consider implanting the smallest acceptable acetabular shell to preserve bone without compromising on head size.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Review
Engineering, Biomedical
Yuqing Mu, Zhibin Du, Lan Xiao, Wendong Gao, Ross Crawford, Yin Xiao
Summary: Bone is capable of remodeling its size, shape, and quality to maintain its strength and meet the body's needs. This remodeling process is regulated by interactions among different types of cells, extracellular matrix, surrounding environments, and cell metabolisms. Inorganic ions released during bone matrix degradation not only form apatite crystals or enter the bloodstream, but also modulate cellular activities. The understanding of the naturally balanced ionic microenvironment during bone remodeling can guide the design of biomaterials for bone tissue engineering.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Medicine, Research & Experimental
Anand Kumar Meka, Akshatha Gopalakrishna, Claudia Iriarte-Mesa, Prarthana Rewatkar, Zhi Qu, Xiaoxin Wu, Yuxue Cao, Indira Prasadam, Taskeen Iqbal Janjua, Freddy Kleitz, Tushar Kumeria, Amirali Popat
Summary: Coenzyme Q10 is a powerful antioxidant with various therapeutic applications, but it has low solubility and bioavailability. This study investigated the effects of mesoporous silica nanoparticles with different pore sizes and surface modifications on the solubility, release profile, and intracellular antioxidant activity of coenzyme Q10. Surface modification with phosphonate groups significantly enhanced the solubility of coenzyme Q10 compared to pristine and amino-modified particles. Moreover, phosphonate-modified MCM-41 nanoparticles showed the highest solubility and decreased ROS generation in human chondrocyte cells. These findings highlight the importance of small pore size and negative surface charge in improving the solubility and antioxidant activity of coenzyme Q10.
MOLECULAR PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Xiwei Fan, Kah Meng Lee, Michael W. M. Jones, Daryl Howard, Antonia Rujia Sun, Ross Crawford, Indira Prasadam
Summary: This study used synchrotron X-ray fluorescence microscopy (SR-XFM) to determine the relationship between element distribution and osteoarthritis (OA) progression. The results showed significant differences in zinc (Zn) and calcium (Ca) compositions between non-OA and OA samples. The tidemark separating noncalcified and calcified cartilage was rich in zinc. In addition, the zinc levels in OA samples were lower than in non-OA samples.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Xiaoxin Wu, Antonia RuJia Sun, Ross Crawford, Yin Xiao, Yanping Wang, Indira Prasadam, Xinzhan Mao
Summary: Chronic inflammation plays a crucial role in osteoarthritis (OA) pathology, but its impact on OA disease progression remains unclear. This study found that leukotriene B4 (LTB4) and its upstream enzyme, Leukotriene A(4) hydrolase (LTA(4)H), were highly expressed in OA cartilage. Inhibition of LTA(4)H showed therapeutic potential by suppressing cartilage degeneration and promoting regeneration, suggesting LTA(4)H as a potential therapeutic target for OA.
Review
Chemistry, Multidisciplinary
Jingyi Wen, Donglin Cai, Wendong Gao, Ruiying He, Yulin Li, Yinghong Zhou, Travis Klein, Lan Xiao, Yin Xiao
Summary: Treatment of large bone fractures is challenging, but osteoimmunology has been used to develop biomaterials for advanced bone regeneration. Nanoparticle-based drug delivery systems enable controlled release and targeted delivery, benefiting bone regeneration through osteoimmunomodulation. This review discusses the significance of osteoimmunology, the advancement of NP-based approaches, and the application of NPs in macrophage-targeting drug delivery for advanced osteoimmunomodulation.
Article
Chemistry, Multidisciplinary
Lin Du, Chen Qin, Hongjian Zhang, Fei Han, Jianmin Xue, Yufeng Wang, Jinfu Wu, Yin Xiao, Zhiguang Huan, Chengtie Wu
Summary: A biomimetic ink mimicking the tendon/bone tissues was developed using tendon/bone-related cells and Mo-containing silicate (MS) bioceramics. Biomimetic multicellular scaffolds were then fabricated via 3D bioprinting to simulate the hierarchical structure and cellular composition of tendon-to-bone interfaces. The study is significant for inducing the regeneration of complex structures in the interface region.
Article
Cell Biology
Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Ye
Summary: This study demonstrated that miR-155 could protect against cholesterol-induced intervertebral disc degeneration (IDD) by targeting RORa to inhibit matrix degradation, apoptosis, and pyroptosis in the nucleus pulposus (NP).
CELLULAR SIGNALLING
(2023)
Article
Engineering, Biomedical
Hai-Feng Liang, Yan-Pei Zou, An-Nan Hu, Ben Wang, Juan Li, Lei Huang, Wei-Sin Chen, Di-Han Su, Lan Xiao, Yin Xiao, Yi-Qun Ma, Xi-Lei Li, Li-Bo Jiang, Jian Dong
Summary: This study developed a biomimetic magnetic scaffold to mimic the structure and composition of bone using magnetic nanoparticles and specific protein structures. The results showed that the scaffold, when stimulated by a static magnetic field, promoted cell migration and osteogenic differentiation, and also facilitated new bone formation in animal experiments. The study also revealed the molecular mechanisms underlying bone formation, which involves the release of calcium ions from the endoplasmic reticulum.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Guohou Miao, Liyu Liang, Wenzhi Li, Chaoyang Ma, Yuqian Pan, Hongling Zhao, Qing Zhang, Yin Xiao, Xuechao Yang
Summary: In this study, a multi-component hydrogel was developed for the fabrication of tissue engineering scaffolds via bioprinting, showing good biological activity and regenerative capabilities for periodontal tissue.
Article
Automation & Control Systems
Andrew Razjigaev, Ajay Pandey, David Howard, Jonathan Roberts, Anjali Jaiprakash, Ross Crawford, Liao Wu
Summary: This study proposes a semiautonomous controller to assist teleoperation by steering a camera to keep a target in the center of the field of view, thus assisting in surveying different orientations about the target with image-based information. The proposed techniques are simulated and validated on the SnakeRaven robot, with successful operation achieved.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Pharmacology & Pharmacy
Tingyu Jin, Ziwen Zhang, Yin Xiao, Xuerong Geng, Xingyi Zhu
Summary: PZ-malic acid cocrystal was prepared using liquid assisted grinding method to improve the poor water solubility and light instability of PZ. The cocrystal showed improved solubility in water and simulated intestinal environment, as well as good light and thermal stability. However, phase separation of the cocrystal in water required the addition of a suitable amount of polymer.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Article
Medicine, Research & Experimental
Xiwei Fan, Reuben S. E. Young, Antonia Rujia Sun, Brett R. Hamilton, Udhaya Nedunchezhiyan, Ross Crawford, Stephen J. Blanksby, Indira Prasadam
Summary: This study used mass spectrometry imaging to visualize the distribution of lipase enzymes in bone and cartilage tissue sections and correlated them with immunohistochemistry staining results. The results showed that OA patients exhibited increased expression of PLA(2)G(2)A at the superficial and deep cartilage zones, indicating that tissue-specific inhibition of PLA(2)G(2)A may be a potential therapeutic target for OA.
Article
Materials Science, Multidisciplinary
Jiajie Chen, Yinghui Wang, Chengtie Wu, Yin Xiao, Yufang Zhu
Summary: This study developed a dendritic mesoporous silica nanoparticle decorated with SARS-CoV-2 spike protein for targeted delivery of RNA-dependent RNA polymerase-specific siRNA to combat SARS-CoV-2 infection. The results demonstrated improved silencing effect on the transfected SARS-CoV-2 gene and suggested the potential of this nanosystem as a promising treatment option for SARS-CoV-2 infection.
APPLIED MATERIALS TODAY
(2023)