Article
Cell Biology
Yuan Qiao, Shan Zhu, Shuanglin Deng, Shan-Shan Zou, Bao Gao, Guoxia Zang, Jing Wu, Yuxue Jiang, Yong-Jun Liu, Jingtao Chen
Summary: Human epithelial cancer cells respond to cytosolic RNA through the RIG-I-MAVS pathway but only sense cytosolic DNA through the cGAS-STING pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Feng Liu, Wanxin Zhuang, Bin Song, Yuan Yang, Junqi Liu, Yi Zheng, Bingyu Liu, Jie Zheng, Wei Zhao, Chengjiang Gao
Summary: In this study, the researchers discovered that K63-linked polyubiquitin chains loaded on MAVS can be recognized by RIG-I to initiate MAVS aggregation. They also identified Ube2N as a major enzyme involved in the polyubiquitination of MAVS and found that it cooperates with Riplet and TRIM31 to promote unanchored polyubiquitination. Additionally, they identified USP10 as a deubiquitinating enzyme that removes unanchored polyubiquitin chains from MAVS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Microbiology
Boyu Zhai, Lanlan Liu, Xiang Li, Xinru Lv, Jinyan Wu, Jing Li, Shengze Lin, Yuxiang Yin, Jiaqi Lan, Jianan Du, Chenwei Wu, Yi Wen, Yajun Wang, Yulong Wang, Zhijun Hou, Yanbing Li, Hongliang Chai, Xiangwei Zeng
Summary: This study examined the innate immune responses of ducks to avian influenza infection using wild-bird-origin viruses H5N8 and H4N6. The expression levels of RIG-I and interferon beta (IFN-beta) fluctuated during infection, with the viruses exhibiting varying degrees of inhibition on the immune response. The highly pathogenic H5N8 virus had a stronger inhibitory effect on RIG-I, particularly in the lungs. RIG-I and IFN-beta were found to play important roles in the innate immune response to H5N8 infection, especially in the lungs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anne K. Kronborg Hansen, Magdalena Dubik, Joanna Marczynska, Bhavya Ojha, Estanislao Nistal-Villan, Gloria Gonzalez Aseguinolaza, Dina S. Arengoth, Trevor Owens, Reza Khorooshi
Summary: This study investigated the potential therapeutic effect of activating the RIG-I signaling pathway to promote the production of IFN beta within the central nervous system (CNS) and its impact on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The results demonstrate that intrathecal administration of AAV-CM resulted in sustained IFN beta expression within the CNS and suppressed the development of EAE. These findings suggest that targeting the downstream signaling pathway of RIG-I represents a promising therapeutic strategy for inflammatory CNS diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wei Liu, Zhenling Ma, Yaru Wu, Cui Yuan, Yanyan Zhang, Zeyang Liang, Yu Yang, Wenwen Zhang, Pengtao Jiao
Summary: This study reveals that MST4 acts as a negative regulator of type I interferon (IFN) production during viral immune responses. MST4 inhibits the production of type I IFN by competing with TRAF3 for binding to MAVS, thereby preventing the TRAF3/MAVS association. Additionally, MST4 promotes the degradation of MAVS through the interaction with the E3 ubiquitin ligase Smurf1 and the subsequent K48-linked ubiquitination of MAVS.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Weiqiang Li, Yating Song, Yuqing Du, Zhanhong Huang, Meng Zhang, Zuxian Chen, Zhuoliang He, Yangbao Ding, Junsheng Zhang, Luxiang Zhao, Hailiang Sun, Peirong Jiao
Summary: This study identified the duTRIM29 gene in ducks, which negatively regulates the production of type I interferons by interacting with and degrading duMAVS. This research provides valuable insights into the molecular mechanisms of TRIM proteins in regulating the innate immune response in ducks.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhigao Chen, Min Yin, Haixue Jia, Qian Chen, Hongbing Zhang
Summary: This study found that enhancing endogenous double-stranded RNA (dsRNA) expression can activate anti-tumor immunity in ovarian carcinoma through induction of type I interferon (IFN). Patients in the immune intervention group had a better prognosis, and the ISG20 gene was identified as playing a crucial role in this process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adham Abuelola Mohamed, Sofia Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. G. Brooks, Martin Schlee
Summary: NK cell activation in response to Influenza A virus infection depends on the cytosolic RNA receptor RIG-I, and activation of RIG-I enhances both the antiviral defense and cytotoxic effector function of NK cells against target cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ya-Xian Yang, Jing-Ping Huang, Sheng-Na Li, Jing Li, Ting Ling, Tao Xie, Liang-Guo Xu
Summary: HSPBP1 promotes RIG-I-mediated signal transduction by inhibiting K48-linked ubiquitination of RIG-I, leading to increased stability of RIG-I protein, activation of IRF3, and enhanced production of IFN-beta.
MOLECULAR IMMUNOLOGY
(2021)
Article
Fisheries
Xifeng Hu, Xiangdong Wu, Meijia Xue, Yiting Chen, Beiyi Zhou, Tong Wan, Hongnan You, Huansheng Wu
Summary: The study found that chTAX1 inhibits IFN expression by promoting degradation of chicken MAVS, and after IBDV infection, the distribution of chTAX1 changes and co-localizes with VP1 and VP3. Overexpression of chTAX1 promotes IBDV replication.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Virology
Jiaying Yu, Haitao Shi, Ke Song, Yuxin Yang, Xinmiao Li, Luyuan Peng, Bendong Fu, Pengfei Yi
Summary: Porcine reproductive and respiratory syndrome (PRRS) is a major disease in the swine industry, and its pathogen PRRSV has immunosuppressive properties. This study investigated the modulatory effect of naringenin on the suppressed innate immune response after PRRSV infection and found that it improved the expression of antiviral cytokines and activated the RIG-I-MAVS immune signaling pathway. These findings suggest that naringenin may have potential as a drug against immunosuppressive viral infections.
Article
Multidisciplinary Sciences
Xuemei Bai, Chao Sui, Feng Liu, Tian Chen, Lei Zhang, Yi Zheng, Bingyu Liu, Chengjiang Gao
Summary: This study discovered that PRMT9 directly targets MAVS and methylates it, inhibiting the aggregation and autoactivation of MAVS. This provides an explanation for the regulatory mechanism of MAVS in maintaining innate immune homeostasis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yingqi Huang, Wei Liang, Kun Li, Xialin Liao, Jiawen Chen, Xiusheng Qiu, Kunpeng Liu, Dongbo Qiu, Yunfei Qin
Summary: The Type I interferon pathway plays a crucial role in innate immune signaling, and an imbalance in interferon levels can lead to various diseases. This study demonstrates that sorafenib suppresses the Type I interferon pathway by inducing the degradation of key proteins and attenuating signaling transduction. These findings highlight the negative role of sorafenib in the regulation of the Type I interferon pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Yongzhen Liu, Chao Qin, Youliang Rao, Chau Ngo, Joshua J. Feng, Jun Zhao, Shu Zhang, Ting-Yu Wang, Jessica Carriere, Ali Can Savas, Mehrnaz Zarinfar, Stephanie Rice, Hanging Yang, Weiming Yuan, Julio A. Camarero, Jianhua Yu, Xiaojiang S. Chen, Chao Zhang, Pinghui Feng
Summary: The study reveals the innate immune evasion strategy of SARS-CoV-2 mediated by the Nsp5 main protease and the development of a small-molecule inhibitor, which restores the innate immune response and inhibits viral replication. These findings provide potential antiviral agents for treating COVID-19 patients.
Article
Immunology
Huasong Chang, Peili Hou, Xuefeng Wang, Aibiao Xiang, Hao Wu, Wenjing Qi, Rukun Yang, Xue Wang, Xingyu Li, Wenqi He, Guimin Zhao, Weiyang Sun, Tiecheng Wang, Daniel Chang He, Hongmei Wang, Yuwei Gao, Hongbin He
Summary: This study reveals that CD97 acts as a negative regulator of RIG-I in the antiviral immune response. Overexpression of CD97 promotes the degradation of RIG-I, leading to the suppression of IFN-I signaling pathway and enhancing RNA virus replication. These findings provide insights into the functional mechanism of CD97 in antiviral immunity and offer a molecular basis for the development of new therapeutic strategies and targeted antiviral agents.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mihee Yun, Gimoon Seo, Ji-Young Lee, Gue Tae Chae, Seong-Beom Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Dermatology
Gimoon Seo, Eunhye Oh, Mihee Yun, Ji-Young Lee, Joon Sung Bae, Kwon Joo, Gue Tae Chae, Seong-Beom Lee
EXPERIMENTAL DERMATOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Seong Keun Kim, Eunhye Oh, Mihee Yun, Seong-Beom Lee, Gue Tae Chae
LIPIDS IN HEALTH AND DISEASE
(2015)
Article
Multidisciplinary Sciences
Ji-Young Lee, Ji-Sun Paik, Mihee Yun, Seong-Beom Lee, Suk-Woo Yang
Article
Infectious Diseases
Song-Hyo Jin, Sung-Kwan An, Seong-Beom Lee
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Biochemistry & Molecular Biology
Kyung-Mi Lee, Jung Hoon Kang, Mihee Yun, Seong-Beom Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Dermatology
Yun Jung Kim, Seong-Beom Lee, Hyang Burm Lee
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Dermatology
Eunhye Oh, Mihee Yun, Seong Keun Kim, Gimoon Seo, Joon Sung Bae, Kwon Joo, Gue Tae Chae, Seong-Beom Lee
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2014)
Article
Infectious Diseases
Song-Hyo Jin, Se-Kon Kim, Seong-Beom Lee
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Biochemistry & Molecular Biology
Yujin Lee, Junghoon Kang, Mihee Yun, Seong-Beom Lee
MOLECULAR & CELLULAR TOXICOLOGY
(2019)
Article
Immunology
Ji Sun Paik, Sung-Eun Kim, Ji Hyun Kim, Ji-Young Lee, Suk-Woo Yang, Seong-Beom Lee
Article
Multidisciplinary Sciences
Sung Eun Kim, Jia Kim, Ji-Young Lee, Seong-Beom Lee, Ji-Sun Paik, Suk-Woo Yang
Summary: Patients with TAO had higher levels of IGF-1 secretion and NF-kappa B activity in OFs, which were inhibited by treatment with octreotide. These OFs also expressed higher levels of SSTR2 on the cell surface.
Article
Biochemistry & Molecular Biology
Seong Keun Kim, Mihee Yun, Gimoon Seo, Ji-Young Lee, Seong-Beom Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Ophthalmology
Ji-Young Lee, Mihee Yun, Ji-Sun Paik, Seong-Beom Lee, Suk-Woo Yang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)