Article
Cell Biology
Hyun Jeong Joo, Matthew D'Alessandro, Gaeun Oh, Sora Han, Woo Jung Kim, Ga Eun Chung, Youjeong Jang, Jung Bok Lee, Choogon Lee, Young Yang
Summary: This report identifies ubiquitin E3 ligase beta-TrCP2 as a master regulator of carbohydrate and lipid metabolism. Knockout of beta-TrCP2 in beta-TrCP1 knockout adult mice resulted in rapid loss of fat mass. Biochemical analysis revealed upregulation of glycolysis, fatty acid oxidation, and lipolysis in beta-TrCP2 knockout mice. The absence of beta-TrCP2 increased the stability of rate-limiting enzymes involved in glucose and fatty acid metabolism. Targeting beta-TrCP could be a potential strategy for treating obesity and metabolic disorders.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Virology
Wenhui Tu, Jin Liu, Feng Qian, Li Zhu, Ming Li, Hui Zheng, Chuanwu Zhu
Summary: Chronic hepatitis B (CHB) cannot be cured currently, but a functional cure might be possible by reducing hepatitis B surface antigen (HBsAg) levels through protein ubiquitination. Our study confirmed that beta-TrCP is the E3 ubiquitin ligase of HBsAg, and can degrade HBsAg through the proteasome pathway. Furthermore, beta-TrCP affects the K48-linked polyubiquitin chain by acting on Myc-HBsAg. Thus, targeting the ubiquitin degradation pathway of HBsAg may help in achieving a functional cure for CHB.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Javier Casas, Clara Meana, Jose Ramon Lopez-Lopez, Jesus Balsinde, Maria A. Balboa
Summary: This study reveals the activation of the TRPC3 channel during macrophage exposure to LPS, which is essential for intracellular Ca2+ release. TRPC3 participates in cytosolic Ca2+ elevations, NF-kappa B activation, and cytokine upregulation. Pharmacological inhibition of TRPC3 reduces LPS-induced systemic inflammation in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Ye Tan, Di Wu, Ze-Yu Liu, Hong-Qiang Yu, Xiang-Ru Zheng, Xiao-Tong Lin, Ping Bie, Lei-Da Zhang, Chuan-Ming Xie
Summary: HLTF downregulation in hepatocellular carcinoma is associated with beta-TrCP-mediated degradation, leading to increased p62 transcriptional activity and mTOR activation. The decreased expression of HLTF is positively correlated with elevated expression of beta-TrCP, p62, and p-mTOR in HCC patients. This finding reveals a new oncogenic driver and provides a potential therapeutic strategy for HCC by targeting the beta-TrCP/HLTF/p62/mTOR axis.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Raquel Fernandez-Gines, Jose Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodriguez-Franco, Ana Rojo, Antonio Cuadrado
Summary: A novel small molecule, PHAR, has been discovered to selectively inhibit the interaction between the non-canonical repressor beta-TrCP and the phosphodegron in transcription factor NRF2. PHAR disrupts this interaction in the cell nucleus, upregulates NRF2-target genes, and shows potential therapeutic value against oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Raquel Fernandez-Gines, Jose Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodriguez-Franco, Ana Rojo, Antonio Cuadrado
Summary: A new small molecule, PHAR, has been discovered to selectively inhibit the interaction between NRF2 and its non-canonical repressor beta-TrCP, offering a potential therapeutic approach for combating undesirable inflammation.
Article
Biochemistry & Molecular Biology
Pengbo Yao, Taiqi Chen, Peng Jiang, Li Li, Wenjing Du
Summary: This study reveals that macrophage polarization plays a crucial role in determining the production of pro- or anti-inflammatory cytokines during bacterial and virus infections. It was found that lipopolysaccharide-induced pro-inflammatory macrophage polarization enhances the interaction between TRIM21 and SIRT5, leading to SIRT5 degradation and enhanced interleukin-1 beta production.
Article
Microbiology
Suzanne Pickering, Jonathan Sumner, Claire Kerridge, Marianne Perera, Stuart Neil
Summary: The HIV-1 Vpu protein inhibits NF-κB signaling by binding and inhibiting β-TrCP, and it simultaneously exploits the different paralogues of β-TrCP to degrade its cellular targets, resulting in potent inhibition of both the canonical and non-canonical NF-κB pathways.
Article
Cell Biology
Lian Li, Jianxin Wei, Tomeka L. Suber, Qinmao Ye, Jiaxing Miao, Shuang Li, Sarah J. Taleb, Kevin C. Tran, Arya S. Tamaskar, Jing Zhao, Yutong Zhao
Summary: IL-37 induces Sigirr phosphorylation and degradation through GSK3 beta-mediated pathways, revealing a potential mechanism in regulating inflammatory responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rongxin Li, Dan Zhang, Yueqing Han, Ke Chen, Weiran Guo, Yijun Chen, Shuzhen Wang
Summary: In this study, the researchers found that the expression of EphB1 is significantly increased in activated HSCs, accompanied by remarkable neddylation. This neddylation enhances the kinase activity of EphB1, promoting HSC proliferation, migration, and activation, and thus contributing to the development of liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vincent Pretre, Dimitrios Papadopoulos, Jean Regard, Marc Pelletier, Janghee Woo
Summary: Inflammation plays a significant role in the development and progression of cancer. Inflammation in the tumor microenvironment alters the adaptability of tumor cells, promoting their survival and progression. Recent studies have shown that inhibiting interleukin-1 beta (IL-1 beta) can significantly decrease the risk of lung cancer. This article reviews the role of IL-1 beta and its upstream regulator NLRP3 in solid tumor and hematologic malignancies, and discusses the pharmacologic tools used to evaluate the effects of blocking tumor-promoting inflammation.
Editorial Material
Immunology
Cecilia Garlanda, Domenico Supino
Summary: The researchers in this study designed a new drug to selectively inhibit IL-1 by analyzing an IL-1 receptor missense mutation associated with un-leashed IL-1-mediated inflammation.
Article
Medicine, Research & Experimental
Bin Li, Liao Xu, Jiangwen Liu, Mingmin Zhou, Xuejun Jiang
Summary: The objective of this study was to investigate the potential role of Phloretin in cardiac contractile and electrical conduction function after myocardial infarction (MI). The findings suggest that Phloretin inhibits the NLRP3/Caspase-1/IL-1 beta pathway, leading to the upregulation of Cx43 by limiting p38 phosphorylation, which further decreases susceptibility to ventricular arrhythmias (VAs) and prevents heart failure (HF).
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Immunology
Bo-Wei Liao, Hong-Yan Zhang, Wen-Tian Du, Yong Ran, Yan-Yi Wang, Zhi-Sheng Xu
Summary: IL-1β is a crucial mediator of inflammatory responses, and its signaling is finely regulated by various mechanisms. This study identified FAM177A1 as a negative regulator of IL-1β-induced signaling, which competitively binds to TRAF6 and impairs its downstream signaling cascade.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Takeru Kondo, Keiichi Kanayama, Hiroshi Egusa, Ichiro Nishimura
Summary: Tooth extraction is a last resort treatment for resolving pathological complications of dentition induced by infection and injury. Although the extraction wound generally heals uneventfully, resulting in the formation of an edentulous residual ridge, some patients experience long-term and severe residual ridge reduction. The objective of this review was to provide a contemporary understanding of the molecular and cellular mechanisms that may potentially cause edentulous jawbone resorption.
JOURNAL OF PROSTHODONTIC RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yoshihiro Akashi, Atsuhiro Nagasaki, Hiroko Okawa, Takuya Matsumoto, Takeru Kondo, Hirofumi Yatani, Ichiro Nishimura, Hiroshi Egusa
Summary: This study aimed to investigate the involvement of oral mucosa cells in mechanical stress-induced bone resorption. The results showed that cytokines from human gingival fibroblasts under high pressure stimulation could promote osteoclast activity in vitro. These findings reveal the possible role of gingival fibroblasts in mechanical stress-induced alveolar ridge resorption, such as in denture wearers.
JOURNAL OF PROSTHODONTIC RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Nadia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa
Summary: Researchers have successfully created a smart titanium nanosurface that mimics the surface properties of tooth root cementum, leading to the regeneration of periodontal tissues. This nanosurface induces the formation of dentoalveolar fibrous joints, resulting in the regeneration of functional periodontium.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yoko Iwamatsu-Kobayashi, Jun Watanabe, Taro Kusama, Hideaki Endo, Shinobu Ikeda, Koichi Tokuda, Kaoru Igarashi, Hiroshi Egusa
Summary: This study analysed the risk factors for needlestick and sharps injuries (NSIs) in dental healthcare workers (DHCWs) at Tohoku University Hospital (TUH) in Japan over a 19-year period. The study found that NSIs occurred mainly in DHCWs with less than 5 years of experience, and injection needles were the most common cause of NSIs. Needle injuries mainly occurred on the left hand, while injuries from ultrasonic scaler chips and burs occurred on the right hand and other body parts when DHCWs were placing the instruments back without removing the sharps. No cases of occupational blood-borne infections caused by NSIs were observed during the study period. The study concludes that monitoring NSIs and developing strategies to minimize them is necessary.
INTERNATIONAL DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jeeranan Manokawinchoke, Suconta Chareonvit, Vorapat Trachoo, Phoonsuk Limraksasin, Hiroshi Egusa, Thanaphum Osathanon
Summary: This study investigated the effect of intermittent compressive force (ICF) on the expression of dentin matrix protein-1 (DMP1) in human periodontal ligament stem cells (hPDLSCs). It was found that ICF could induce DMP1 expression through the regulation of the TGF-b signaling pathway.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nadia Kartikasari, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Xindie He, Hiroshi Egusa
Summary: This study demonstrates that two-dimensional titania nanosurfaces created by alkaline etching treatment can activate macrophage phagocytosis and enhance the expression of phagocytosis-related receptors through nanospike-mediated contact stimulation. This finding provides a new research direction for the treatment of inflammatory or autoimmune diseases.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii
Summary: This study evaluated the effectiveness of the third dose of mRNA COVID-19 vaccine after close contact with COVID-19 cases. The results showed that the vaccine was approximately 40% effective in preventing infection during the Omicron outbreak.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa
Summary: This study reveals that Epfn activation promotes ameloblast induction from mouse iPSCs by upregulating BMP-Smad activity, suggesting Epfn as a promising target for enamel and tooth regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xindie He, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Minoru Ishibashi, Hideki Kitaura, Itaru Mizoguchi, Hiroshi Egusa
Summary: This study investigated the effects of titanium nanosurfaces on the development of osteocyte lacunar-canalicular networks and osseointegration of dental implants. The results showed that titanium nanosurfaces promoted the development of osteocyte lacunar-canalicular networks and strengthened osseointegration.
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hiroaki Kakinuma, Kuniyuki Izumita, Nobuhiro Yoda, Hiroshi Egusa, Keiichi Sasaki
Summary: This study compared the dimensional accuracies of 3D-printed and milled resin-composite crowns, and determined acceptable abutment-tooth shapes for printing. The results showed that regardless of the abutment form, 3D-printed crowns had higher accuracy with fewer marginal discrepancies.
DENTAL MATERIALS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Phoonsuk Limraksasin, Praphawi Nattasit, Jeeranan Manokawinchoke, Watcharaphol Tiskratok, Naruephorn Vinaikosol, Hiroko Okawa, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus, Prasit Pavasant, Thanaphum Osathanon, Hiroshi Egusa
Summary: The study demonstrates that shear stress at 0.5 Pa can enhance the osteogenic differentiation of iPSCs through promoting Cx43 and Erk1/2 signaling pathways.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Nadia Kartikasari, Tsuyoshi Kimura, Hiroshi Egusa
Summary: Soft gingiva is often compromised in gingival health, but the underlying biological mechanisms remain unknown. In vitro investigation showed that substrate stiffness influences proinflammatory responses in human gingival fibroblasts. Soft substrate induced proinflammatory responses and inhibition of extracellular matrix (ECM) synthesis in hGFs by inactivating cellular mechanotransduction, highlighting the importance of ECM stiffness in gingival health.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Hiroshi Egusa
JOURNAL OF PROSTHODONTIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Qu Pengyu, Tsuyoshi Kimura, Hiroshi Egusa
Summary: A study found that the stiffness of the PDMS substrate can regulate the osteoclastogenesis-inducing potential of L929 cells through cellular mechanotransduction. L929 cells cultured on soft PDMS substrates showed increased expression of osteoclastogenesis-inducing factors, promoting the differentiation of RAW 264.7 cells. However, the cellular response of L929 cells on hard PDMS substrates was minimally affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takeru Kondo, Hiroaki Kakinuma, Kanna Fujimura, Sara Ambo, Koki Otake, Yumi Sato, Hiroshi Egusa
Summary: This study investigated the effects of dual-cured resin cement, with incomplete polymerization owing to attenuated light through zirconia, on the inflammatory response in vitro. The results suggest that dual-cured resin cement with incomplete polymerization induces inflammatory responses in hGFs and monocytic cells by intracellular ROS generation and MAP kinase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)