Article
Cell & Tissue Engineering
Yongfeng Li, Huawei Liu, Chao Wang, Rongzeng Yan, Lei Xiang, Xiaodan Mu, Lingling Zheng, Changkui Liu, Min Hu
Summary: This study aimed to fabricate 3D-printing titanium grid scaffolds to achieve bone fusion in mandibular segmental defects. The results showed that the scaffolds with sufficient pores and basic biomechanical strength could facilitate bone regeneration and integration of bone broken ends. Clinical observations on both animal models and patients confirmed the successful bone regeneration in mandibular defects using the titanium grid scaffolds.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ezgi Yuceer-Cetiner, Nilufer Ozkan, Mehmet Emin Onger, Mustafa Yavuz Gulbahar, Metehan Keskin
Summary: This study compared different graft materials for reconstructing mandibular bone defects, finding that a combination of autograft and xenograft was more effective than using either alone or leaving the defects empty. Immunohistochemical and stereological results support the adoption of the induced membrane technique in humans for small segmental mandibular defect reconstruction.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Review
Engineering, Biomedical
Benjamin Dalisson, Baptiste Charbonnier, Ahmed Aoude, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: This review article discusses different strategies for repairing massive segmental bone defects and explores emerging potential replacements for the standard treatment of fibular transplantation with a blood supply. The review highlights the importance of considering more basic approaches in bone repair and challenges the assumption that mimicry is necessary for success in repair strategies.
ACTA BIOMATERIALIA
(2021)
Article
Orthopedics
Jie Fang, Rongjian Shi, Weiya Qi, Dawei Zheng, Hui Zhu
Summary: The feasibility and clinical outcomes of using the induced membrane technique and autologous structural bone grafting for treatment of phalangeal and metacarpal segmental defects were evaluated. Results showed union of all bone grafts, good wound healing without infection complications, and satisfactory finger motion.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Cell Biology
Tie Liu, Wen Fang, Gang Wu, Yining Li, Janak L. Pathak, Yuelian Liu
Summary: This study investigated the bone defect healing potential of biomimetically fabricated low dose BMP2-doped CaP (BMP2.BioCaP) grafts in sheep humerus/femoral defects. The results showed that BMP2.BioCaP grafts had strong bone regenerative potential, comparable to autologous bone graft and more effective than DBB grafts, while exhibiting lower immunogenicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jan Henkel, Flavia Medeiros Savi, Arne Berner, Stephanie Fountain, Siamak Saifzadeh, Roland Steck, Devakar R. Epari, Maria A. Woodruff, Mark Knackstedt, Michael A. Schuetz, Dietmar W. Hutmacher
Summary: This study presents a newly established preclinical ovine animal model for treating large volume segmental tibial defects. It utilizes mPCL-TCP scaffolds combined with rhBMP-7 and PRP for treatment, with detailed analysis on mechanical properties of the scaffolds, IFM, and DCP-surface strain.
Review
Medicine, Research & Experimental
Filippo Migliorini, Gerardo La Padula, Ernesto Torsiello, Filippo Spiezia, Francesco Oliva, Nicola Maffulli
Summary: Various surgical strategies are available for managing large bone defects, with autologous graft being the most commonly used for reconstruction due to its optimal properties. However, the choice of the best surgical technique is still debated, and no consensus has been reached.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima, Kunio Ishikawa
Summary: The study introduced honeycomb scaffolds containing carbonate apatite for bone reconstruction in orthopedic surgery, demonstrating comparable efficacy to protein and cell scaffolds but at a lower cost and increased safety.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Wei Zhi, Xiaohua Wang, Dong Sun, Taijun Chen, Bo Yuan, Xiangfeng Li, Xuening Chen, Jianxin Wang, Zhao Xie, Xiangdong Zhu, Kai Zhang, Xingdong Zhang
Summary: This study successfully repaired large segmental bone defects in a goat femur model by combining osteoinductive biphasic calcium phosphate (BCP) bioceramic scaffolds with intramedullary nail fixation. The results showed that the BCP scaffold promoted cell proliferation and osteogenic differentiation, and the intramedullary nail fixation maintained stability and structural integrity of the implants. Good integration of the implants with host bone and complete bone substitution in the defect area were observed at 9 and 18 months postoperatively, respectively.
BIOACTIVE MATERIALS
(2022)
Article
Critical Care Medicine
Hening Sun, Charles Godbout, Gareth Ryan, Graeme Hoit, James Higgins, Emil H. Schemitsch, Aaron Nauth
Summary: The study compared two bone grafting procedures in rat models of induced membrane technique (IMT), revealing significantly improved healing outcomes in the second group. This suggests that the revised bone grafting method plays a key role in enhancing healing outcomes and establishing a reliable rat model for IMT.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Cell Biology
Holger Freischmidt, Jonas Armbruster, Emma Bonner, Thorsten Guehring, Dennis Nurjadi, Maren Bechberger, Robert Sonntag, Gerhard Schmidmaier, Paul Alfred Gruetzner, Lars Helbig
Summary: Non-unions present a challenge to trauma surgeons due to limited treatment options, long duration, and unsatisfactory outcomes. Alternative therapeutic strategies are desirable to improve outcomes. This study shows that bone graft substitutes have osteoinductive and osteoconductive effects, while systemic PTH administration can induce vascularization, potentially serving as a synergistic co-treatment with bone graft substitutes.
Article
Critical Care Medicine
Nickolas J. Nahm, Janet D. Conway
Summary: This study retrospectively evaluated the data of patients treated with resorbable polylactide membrane for segmental bone defects. The results showed that the combination of resorbable polylactide membrane, bone morphogenic protein-2, and autograft was a safe and effective method for the treatment of segmental bone defects.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Review
Chemistry, Physical
Maria Pia Ferraz
Summary: This review summarizes the various materials used for bone defect replacement or repair in dentistry and oral and maxillofacial surgeries. Factors such as tissue viability, size, shape, and defect volume influence the choice of material. Autologous bone is the gold standard for bone grafting but has limitations. Alternatives include allografts, xenografts, and synthetic materials. Calcium-phosphate-based ceramics, especially hydroxyapatite, are commonly used due to their similarity to natural bone. This review aims to provide a comprehensive analysis of grafting materials in dentistry and discusses their properties, advantages, and challenges.
Article
Orthopedics
Qiang Huang, Yi Bo Xu, Cheng Ren, Ming Li, Cheng Cheng Zhang, Lu Liu, Qian Wang, Yao Lu, Hua Lin, Zhong Li, Han Zhong Xue, Kun Zhang, Teng Ma
Summary: Bone transport combined with bone graft and internal fixation technique showed better clinical effects in treating large segmental bone defects compared to simple bone transport technique, with shorter time in external fixator, shorter total cure time, lower anxiety score, and improved limb functions.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Ronja Finze, Markus Laubach, Mairim Russo Serafini, Ulrich Kneser, Flavia Medeiros Savi
Summary: Large-volume bone defect regeneration is a complex and time-consuming process with multiple interdependent regeneration phases. Scaffold-guided bone regeneration has shown efficacy in both preclinical and clinical studies. Immunohistochemistry analysis provides valuable insights into the complex bone regeneration processes.
Article
Critical Care Medicine
Alexander Joeris, Tracy Y. Zhu, Simon Lambert, Andrea Wood, Prakash Jayakumar
Summary: Patient-reported outcomes (PROs) capture data related to patients' perception of their health status and aspects of health care delivery. These PROs, along with digital innovations, can be actively incorporated in clinical practice and enable shared decision making. This technology-driven approach enhances musculoskeletal care and improves the clinician-patient experience of decision making.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Economics
Simone Huygens, Heleen Vellekoop, Matthijs Versteegh, Irene Santi, Laszlo Szilberhorn, Tamas Zelei, Balzs Nagy, Apostolos Tsiachristas, Rositsa Koleva-Kolarova, Sarah Wordsworth, Maureen Rutten-van Molken, HEcoPerMed Consortium
Summary: This study addresses the challenges of evaluating histology-independent treatments using entrectinib as an example. It evaluates the cost-effectiveness of testing all patients for NTRK fusions and treating positive cases with entrectinib, compared to no testing and standard care. The results show that testing and treatment have higher costs and effects.
Article
Health Care Sciences & Services
Ayesha Sajjad, Matthijs M. M. Versteegh, Irene Santi, Jan Busschbach, Judit Simon, Leona Hakkaart-van Roijen
Summary: This article describes the aim of estimating a 'pan-European' value set for the EQ-5D-3L to evaluate health care from the perspective of European decision-makers. By comparing and evaluating the methodologies of value sets from 12 European countries, it was found that an OLS model can best represent European preferences, thus enabling the development of a new 'pan-European' value set.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Economics
Saskia de Groot, Irene Santi, Pieter Bakx, Bram Wouterse, Pieter van Baal
Summary: This study estimated informal care costs by age and proximity to death across European regions and showed how these estimates can be included in cost-effectiveness analyses. The results indicated that the use and costs of informal care increase with age and approaching death, and including informal care costs in the cost-effectiveness ratio can have a significant impact ranging from euro200 to euro17,700 per quality-adjusted life-year gained. The conclusion of this study is that considering informal care costs is necessary as it may influence decision-making in life-extending healthcare interventions.
Article
Medicine, General & Internal
Domenico De Mauro, Giuseppe Rovere, Lorenzo Are, Amarildo Smakaj, Alessandro Aprato, Umberto Mezzadri, Federico Bove, Alessandro Casiraghi, Silvia Marino, Gianluca Ciolli, Simone Cerciello, Giuseppe Maccagnano, Giovanni Noia, Alessandro Masse, Giulio Maccauro, Francesco Liuzza
Summary: This study aims to investigate the clinical and radiological outcomes of spring plates in the treatment of comminuted posterior wall acetabular fractures. The results suggest that spring plates can be considered a viable fixation method for posterior wall acetabular fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
M. Giachino, A. Aprato, B. Limone, G. Ciccone, T. Rosso, A. Masse
Summary: The use of 3D-printed models for pre-operative planning can effectively reduce the surgical time, hospital stay, and overall costs of complex revision total hip arthroplasty (rTHA).
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Biochemistry & Molecular Biology
Anja Domenghino, Carmen Walbert, Dominique Lisa Birrer, Milo Puhan, Pierre-Alain Clavien
Summary: Postoperative complications are a significant global public health burden. The lack of standardized and universally applied endpoints for evaluating surgical interventions leads to inconsistent and biased interpretations, hindering patient-centered healthcare delivery. A jury-based consensus conference was conducted to develop recommendations for postoperative outcome assessment, incorporating the perspectives of different stakeholders. The Outcome4Medicine consensus group provides a framework for surgical outcome assessment and quality improvement, integrating the perspectives of the main stakeholders, with the goal of enhancing care quality and patient health.
Article
Orthopedics
Fabricio Fogagnolo, Rodrigo Salim, Jose Leonardo Rocha de Faria, Douglas Mello Pavao, Mauricio Kfuri
Summary: The primary function of the posterior cruciate ligament (PCL) is to restrict the posterior translation of the tibia, and its secondary function is to limit the tibial external rotation, mainly at 90 degrees and 120 degrees of knee flexion. PCL rupture occurs in 3% to 37% of patients with knee ligament tears and is often associated with other ligament injuries. Surgical treatment is recommended for acute PCL injuries associated with knee dislocations or when stress radiographs show a tibial posteriorization greater than or equal to 12 mm.
ARTHROSCOPY TECHNIQUES
(2023)
Review
Orthopedics
Michele Reboli, Alessandro Aprato, Jacopo Vittori, Matteo Olivero, Francesco Bosco, Alessandro Masse
Summary: The study aimed to re-evaluate the appropriate acute surgical treatment of AIIS avulsion fractures considering the three-dimensional anatomy of the supra-acetabular region. Conservative treatment of these injuries has been shown to lead to excellent outcomes, even when there is radiological evidence of displacement. However, some surgeons lack long-term follow-up beyond six months.
JOURNAL OF ORTHOPAEDICS
(2023)
Review
Orthopedics
N. A. Pearson, E. Tutton, S. E. Gwilym, A. Joeris, R. Grant, D. J. Keene, K. L. Haywood
Summary: This study systematically reviewed qualitative studies on patients with distal tibia or ankle fracture, and explored their experience of injury and recovery. The findings suggest that ankle injuries have a significant impact on patients' self-identity and they face various challenges during the recovery process. Clinicians should be aware of the patient experience and consider rehabilitation and psychosocial treatment strategies to address these challenges.
Article
Medicine, Research & Experimental
Irene Santi, Andrew J. Lloyd, Claudia E. Hastedt, Matthijs M. Versteegh
Summary: This study aimed to evaluate the impact of cognitive impairment on quality of life using the Schizophrenia Cognition Rating Scale (SCoRS). Five key items were selected from the SCoRS and valued through one-on-one video calls using composite time trade-off (cTTO). The results showed that the SCoRS was more sensitive in detecting cognitive changes compared to the EQ-5D.
ADVANCES IN THERAPY
(2023)
Article
Orthopedics
Matteo Olivero, Bruno Capurro, Pedro Reis-Campos, Alessandro Aprato, Olufemi Ayeni, Anuj Chawla, Ricardo Larrainzar Garijo, Oliver Marin-Pena
Summary: This study analyzed data from 98 sport participant patients who underwent arthroscopic or anterior mini-open treatment for femoroacetabular impingement (FAI). The results suggest that anterior mini-open treatment is associated with a higher risk of heterotopic ossification (HO) compared to hip arthroscopy, and that a treatment regimen of 60 mg etoricoxib daily for two weeks is effective in preventing HO formation in sport participant patients.
Article
Orthopedics
Alessandro Aprato, Matteo Giachino, Alessandra Cipolla, Alessandro Masse
Summary: This paper presents a surgical technique for arthroscopic assistance during open reduction and fixation for complex acetabular fractures, which has not been described in the literature yet.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Alessandro Aprato, Luigi Branca Vergano, Alessandro Casiraghi, Francesco Liuzza, Umberto Mezzadri, Alberto Balagna, Lorenzo Prandoni, Mohamed Rohayem, Lorenzo Sacchi, Amarildo Smakaj, Mario Arduini, Alessandro Are, Concetto Battiato, Marco Berlusconi, Federico Bove, Stefano Cattaneo, Matteo Cavanna, Federico Chiodini, Matteo Commessatti, Francesco Addevico, Rocco Erasmo, Alberto Ferreli, Claudio Galante, Pietro Domenico Giorgi, Federico Lamponi, Alessandro Moghnie, Michel Oransky, Antonio Panella, Raffaele Pascarella, Federico Santolini, Giuseppe Rosario Schiro, Marco Stella, Kristijan Zoccola, Alessandro Masse
Summary: The Italian Pelvic Trauma Association organized a consensus to determine the best treatment for sacral fractures based on neurological impairment, reaching agreements on various diagnostic methods and treatment indications for different scenarios.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Alessandro Aprato, Simone Cambursano, Stefano Artiaco, Stefano Bevilacqua, Paolo Catalani, Alessandro Masse
Summary: Male sex, age older than 65 years, surgical time longer than 90 min, and delayed drainage removal are risk factors for severe heterotopic ossifications.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)