Potential implications of hydrogen peroxide in the pathogenesis and therapeutic strategies of gliomas

Nanocatalytic Medicine

(2019) Bowen Yang et al.   ADVANCED MATERIALS

Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S

(2019) Yaping Li et al.   International Journal of Nanomedicine

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(2019) Li-Sen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunoengineering in glioblastoma imaging and therapy

(2019) Steven Zanganeh et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

(2019) William C. Ballance et al.   BIOMATERIALS

The dual roles of autophagy in gliomagenesis and clinical therapy strategies based on autophagic regulation mechanisms

(2019) Fan Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

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(2018) Marzieh Mohammadi et al.   ADVANCED FUNCTIONAL MATERIALS

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(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

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(2018) Chi Yao et al.   ADVANCED MATERIALS

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(2018) Yong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

(2018) Luksana Chaiswing et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Epigenetics and Oxidative Stress in Gliomagenesis

(2018) Yesennia Sanchez-Perez et al.   CNS & Neurological Disorders-Drug Targets

New Directions in the Treatment of Glioblastoma

(2018) Zachary Reitman et al.   SEMINARS IN NEUROLOGY

Primary brain tumours in adults

(2018) Sarah Lapointe et al.   LANCET

Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer

(2018) Xuejiao Song et al.   NANO LETTERS

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance

(2018) Evan K. Noch et al.   World Neurosurgery

Circulating glioma cells exhibit stem cell-like properties

(2018) Tianrun Liu et al.   CANCER RESEARCH

Immunotherapy for Brain Tumors

(2018) Lan B. Hoang-Minh et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Critical Overview of Targeted Therapies for Glioblastoma

(2018) Kewal K. Jain   Frontiers in Oncology

Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties

(2017) Chang-Nim Im et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in immunotherapeutic research for glioma therapy

(2017) Jeremy Tetsuo Miyauchi et al.   JOURNAL OF NEUROLOGY

Hydrogen Peroxide: A Potential Wound Therapeutic Target

(2017) Guanya Zhu et al.   MEDICAL PRINCIPLES AND PRACTICE

L-Borneol induces transient opening of the blood–brain barrier and enhances the therapeutic effect of cisplatin

(2017) Yi Yin et al.   NEUROREPORT

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

(2017) Qian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O 6 -methylguanine-DNA methyltransferase

(2017) Kwang-Yu Chang et al.   Redox Biology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

(2016) Daniel R. Wahl et al.   CANCER RESEARCH

Hydrogen Peroxide: A Key Chemical for Today's Sustainable Development

(2016) Rosaria Ciriminna et al.   ChemSusChem

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

(2016) Xue-Qing Hu et al.   CURRENT CANCER DRUG TARGETS

A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration

(2016) XiuLing Xu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine

(2016) Anees Rahman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting autophagy to sensitive glioma to temozolomide treatment

(2016) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Current and future strategies for treatment of glioma

(2016) Nancy Ann Oberheim Bush et al.   NEUROSURGICAL REVIEW

Modulating and Measuring Intracellular H2O2 Using Genetically Encoded Tools to Study Its Toxicity to Human Cells

(2016) Beijing K. Huang et al.   ACS Synthetic Biology

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

(2016) Peng Ru et al.   Cell Reports

Role of Redox Status in Development of Glioblastoma

(2016) Aleli Salazar-Ramiro et al.   Frontiers in Immunology

Molecular Pathways in Gliomagenesis and Their Relevance to Neuropathologic Diagnosis

(2015) Christina L. Appin et al.   ADVANCES IN ANATOMIC PATHOLOGY

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress

(2015) Gereon Poschmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

(2015) Claudia Lennicke et al.   Cell Communication and Signaling

Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells

(2015) Hiroyuki Nishi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine

(2015) Siraj Pallichankandy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response

(2015) Lu Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

(2015) Byeong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Radiosensitivity enhancement of radioresistant glioblastoma by epidermal growth factor receptor antibody-conjugated iron-oxide nanoparticles

(2015) Alexandros Bouras et al.   JOURNAL OF NEURO-ONCOLOGY

Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK)

(2015) Jingyan Luo et al.   MOLECULAR BIOLOGY OF THE CELL

Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo

(2015) YANG YANG et al.   ONCOLOGY REPORTS

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

(2015) LIN YE et al.   Oncology Letters

MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species

(2015) Wei Yang et al.   Oncotarget

Triptolide Synergistically Enhances Temozolomide-Induced Apoptosis and Potentiates Inhibition of NF-κB Signaling in Glioma Initiating Cells

(2014) Ke Sai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Detoxification of oxidative stress in glioma stem cells: Mechanism, clinical relevance, and therapeutic development

(2014) Sung-Hak Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2014) Ray R. Zhang et al.   NEUROSURGERY

Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

(2014) Matthew Womeldorff et al.   Neurosurgical Focus

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

(2014) Fan Yang et al.   PLoS One

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

(2014) C R R Rocha et al.   Cell Death & Disease

Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation

(2014) P Daniel et al.   Oncogenesis

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

(2014) Manabu Natsumeda et al.   Acta Neuropathologica Communications

Autophagy and oxidative stress in gliomas with IDH1 mutations

(2013) Misty R. Gilbert et al.   ACTA NEUROPATHOLOGICA

Redox-Modulated Phenomena and Radiation Therapy: The Central Role of Superoxide Dismutases

(2013) Aaron K. Holley et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 is required to maintain the self-renewal of glioma stem cells

(2013) Jianhong Zhu et al.   BMC CANCER

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells

(2013) Ronald-Allan Panganiban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The expression of hypoxia-inducible factor-1 in primary brain tumors

(2013) Joanna Reszec et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma

(2013) Chunzhi Zhang et al.   NEURO-ONCOLOGY

An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation

(2013) Jinlong Shi et al.   NEUROLOGICAL SCIENCES

Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells

(2013) Atsushi Sato et al.   Stem Cell Research

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Differential Nrf2 expression between glioma stem cells and non-stem-like cells in glioblastoma

(2013) JIANHONG ZHU et al.   Oncology Letters

Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ in the Treatment of Brain Tumors

(2012) Stephen T. Keir et al.   Anti-Cancer Agents in Medicinal Chemistry

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

(2012) Peng Zhao et al.   BMC CANCER

Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

(2012) Christoph Klingelhoeffer et al.   BMC Complementary and Alternative Medicine

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress

(2012) Ivana Dokic et al.   GLIA

Forkhead Box M1 Is Regulated by Heat Shock Factor 1 and Promotes Glioma Cells Survival under Heat Shock Stress

(2012) Bingbing Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

Suppression of Peroxiredoxin 4 in Glioblastoma Cells Increases Apoptosis and Reduces Tumor Growth

(2012) Tae Hyong Kim et al.   PLoS One

cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a

(2012) X. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

(2012) Maria Julia Marchissio et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

(2012) Ken-ichiro Matsuda et al.   Scientific Reports

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Caspase 3 is Activated through Caspase 8 instead of Caspase 9 during H2O2-induced Apoptosis in HeLa Cells

(2011) Yinyuan Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells

(2011) Fei Li et al.   FREE RADICAL RESEARCH

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

(2011) Monica Venere et al.   GLIA

Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome

(2011) Hongyu Guan et al.   INTERNATIONAL JOURNAL OF CANCER

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

(2011) Whitney B. Pope et al.   JOURNAL OF NEURO-ONCOLOGY

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

(2011) Shiu Hwa Yeh et al.   NUCLEIC ACIDS RESEARCH

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free radicals and antioxidants – quo vadis?

(2011) Barry Halliwell   TRENDS IN PHARMACOLOGICAL SCIENCES

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(2011) D. Guo et al.   Cancer Discovery

The Role of Nrf2 in Migration and Invasion of Human Glioma Cell U251

(2011) Hao Pan et al.   World Neurosurgery

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Notch signaling in glioblastoma: a developmental drug target?

(2010) Maria Maddalena Lino et al.   BMC Medicine

Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology Consortium

(2010) Melissa L. Bondy et al.   CANCER

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells

(2010) Gimoon Seo et al.   FREE RADICAL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

(2010) Masayuki Nitta et al.   PLoS One

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

(2010) G. C. Van de Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition

(2009) A. Rapisarda et al.   MOLECULAR CANCER THERAPEUTICS

Reactive Oxygen Species Decrease cAMP Response Element Binding Protein Expression in Cardiomyocytes via a Protein Kinase D1-Dependent Mechanism That Does Not Require Ser133 Phosphorylation

(2009) N. Ozgen et al.   MOLECULAR PHARMACOLOGY

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway

(2009) Yu Jeong Byun et al.   NEUROSCIENCE LETTERS

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

Experimental and Systems Biology Studies of the Molecular Basis for the Radioresistance of Prostate Carcinoma Cells

(2008) Ana Niciforovic et al.   ANNALS OF BIOMEDICAL ENGINEERING

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

(2008) Mika Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

(2008) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H2O2

(2008) Pameeka S. Smith-Pearson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons

(2008) Shengjun Chang et al.   NEUROSCIENCE LETTERS

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE