Article
Environmental Sciences
Hui Wang, Suzhen Qi, Xiyan Mu, Lilai Yuan, Yingren Li, Jing Qiu
Summary: This study found that long-term exposure to BPF can lead to liver-gut alteration and metabolic changes in zebrafish. The effects of BPF on liver metabolism were dose-dependent, affecting amino acid, purine, and one carbon metabolism in the 0.5, 5, and 50 mu g/L treatments, respectively. In addition, BPF also caused a shift in intestinal microbiome composition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Mingrong Qian, Jianmei Wang, Xiaofeng Ji, Hua Yang, Biao Tang, Hu Zhang, Guiling Yang, Zhiwei Bao, Yuanxiang Jin
Summary: The wide usage of antibiotics in livestock production leads to residues in animal products and in watercourses. Exposure to antibiotics can cause hepatic metabolic disorder and gut microbiota dysbiosis in adult male zebrafish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Marine & Freshwater Biology
Wenting Lin, Yingjun Qin, Xinying Wang, Mingluo Du, Yukai Wang, Xiaohui Chen, Yuan Ren
Summary: This study investigated the effects of benzodiazepine drugs on the gut-liver axis of zebrafish, and found that the exposure to these drugs led to imbalance of gut microbiota and metabolic disorder, as well as oxidative stress in the liver. The metabolomics analysis also revealed significant alterations in amino acid biosynthesis and other metabolic pathways in the liver. These findings provide valuable data for ecological and environmental risk assessments.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J. Martyniuk, Jian Han, Lihua Yang, Bingsheng Zhou
Summary: This study examined the accumulation and distribution of niclosamide in different tissues of adult male zebrafish fed a normal diet or high-fat diet. The results showed that the liver accumulated the highest concentration of niclosamide, followed by the brain and gonads. High-fat diet increased the burden of niclosamide in the liver and brain compared to the normal diet. Niclosamide effectively controlled weight gain and improved insulin and glucose levels in high-fat diet-fed fish. However, it also had potential effects on the liver-gut axis, disrupting mitochondrial energy production, inhibiting glycemic and triacylglycerol biosynthesis, impairing the physical barrier of the intestine, and causing inflammatory, oxidative stress, and microbiota dysbiosis. These findings emphasize the importance of evaluating the potential impacts of niclosamide on the health of wild animals and humans.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Fisheries
Qiang Ma, Xue Wang, Ling-Yu Li, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du
Summary: This study found that high protein intake can alleviate the reduction of body weight and feed efficiency induced by chronic hypoxia, while high fat diet exacerbates the adverse effects of chronic hypoxia in zebrafish. In the high protein diet groups, hypoxia enhanced utilization of glycogen and protein.
Review
Gastroenterology & Hepatology
Javier Aguilera-Lizarraga
Summary: Abdominal pain, a common symptom worldwide, often occurs after food ingestion. Current treatment strategies mainly focus on excluding culprit food(s) from the diet. However, this approach has limitations, as patients may recognize multiple food items and not all offending foods can be identified. Newly identified mechanisms involving neuroimmune interactions and intestinal microbiota communication are important for developing new therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Food Science & Technology
William Leonard, Pangzhen Zhang, Danyang Ying, Zhongxiang Fang
Summary: Hydroxycinnamic acids (HCAs) are a major class of phenolic acids with a characteristic phenylpropanoid C-6-C-3 backbone. Despite being typically conjugated with plant cell wall components and liberated by limited enzymes, HCAs have been neglected by researchers compared to flavonoid-type polyphenols. Recently, there has been a growing interest in the interactions between polyphenols and gut microbiota, with significant progress in understanding the gut microbiota-modulating effect of HCA using animal model studies.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Environmental Sciences
Bin Wang, Shu-qin Zhang, Jia-li Dong, Yuan Li, Yu-xiao Jin, Hui-wen Xiao, Hai-chao Wang, Sai-jun Fan, Ming Cui
Summary: This study investigated the effects of temperature on the radiosensitivity of zebrafish and identified potential biochemical mechanisms responsible for influencing radiosensitivity. The results suggest that gut microbiota configurations shaped by different temperatures may play a key role in modulating hepatic functions and radiosensitivity in zebrafish. Maintaining the stability of gram-positive bacteria could be efficacious in protecting aquatic organisms against radioactive contamination in the context of global climate change.
ENVIRONMENTAL POLLUTION
(2022)
Article
Nutrition & Dietetics
Qianwen Ding, Chenyao Lu, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhen Zhang, Zhigang Zhou
Summary: This study found that an appropriate amount of succinate can promote the growth and feed intake of zebrafish, increase lipid synthesis, improve glucose balance, and spare protein. However, it may also cause hepatic fat accumulation and gut microbiota dysbiosis.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Yi Huang, Yuhang Hong, Shu Wu, Xiaozhen Yang, Qiang Huang, Yanzhen Dong, Dayong Xu, Zhiqiu Huang
Summary: The present study investigated the toxic effects of IMI on the brain and gut of zebrafish by analyzing the transcriptome and microbiome. The results showed that prolonged darkness improved survival rate and attenuated oxidative stress induced by IMI exposure. Microbiome analysis also revealed changes in gut bacterial community structure and tryptophan metabolism pathway inhibition, which were alleviated in the prolonged darkness group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Marina Romani-Perez, Clara Bullich-Vilarrubias, Inmaculada Lopez-Almela, Rebeca Liebana-Garcia, Marta Olivares, Yolanda Sanz
Summary: Obesity is a major societal and health challenge globally, with the gut microbiota-diet interactions potentially playing a role in its development. Feeding time and dietary composition are important factors influencing gut microbiota structure and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Divakar Dahiya, Poonam Singh Nigam
Summary: Antibiotic therapy can harm the normal microbiota of the gastrointestinal tract, resulting in decreased diversity, changed metabolic activity, and the emergence of antibiotic-resistant strains. This can lead to antibiotic-associated diarrhoea and recurrent infections. Different classes of antibiotics can also cause gastrointestinal, immunologic, and neurocognitive conditions. Restoring the imbalanced gut microbiota to a healthy state is crucial for overall well-being. Probiotic strains, consumed through food, beverages, or supplements, can help establish a beneficial gut-brain relationship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Tianlin Gao, Chunyan Tian, Ge Tian, Li Ma, Lili Xu, Wendong Liu, Jing Cai, Feng Zhong, Huaqi Zhang, Aiguo Ma
Summary: Excessive fructose intake can negatively impact bone development in female adolescent rats, leading to weight gain, abnormal glucose and lipid metabolism, and impaired bone microstructure. This effect may be mediated through alterations in gut microbiota, energy metabolism, and bone metabolism markers.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiaoqiao Luo, Ruoyu Shi, Yutong Liu, Libo Huang, Wei Chen, Chengtao Wang
Summary: In this study, it was found that components in Huangjiu, especially histamine, can increase oxidative stress and inflammatory cytokines in the liver and serum of mice. The gut microbiota community is also affected, with an increase in lipopolysaccharide levels. The study suggests a possible relationship between gut microbiota and liver pyroptosis, and highlights the potential health risks associated with Huangjiu consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Lu-Yuan Peng, Hai-Tao Shi, Zi-Xuan Gong, Peng-Fei Yi, Bo Tang, Hai-Qing Shen, Ben-Dong Fu
Summary: Chicken colibacillosis caused by APEC leads to significant economic losses in the poultry industry. This study demonstrated the importance of gut microbiota in defending against APEC infection in chickens. Depletion of gut microbiota increased susceptibility to APEC challenge, while acetate derived from gut microbiota acted as a protective mediator during the infection.
VETERINARY MICROBIOLOGY
(2021)
Article
Fisheries
Mingxu Xie, Yadong Xie, Yu Li, Wei Zhou, Zhen Zhang, Yalin Yang, Rolf Erik Olsen, Chao Ran, Zhigang Zhou
Summary: The study suggests that low-level uPP addition can enhance fish meal replacement, while 5% uPP in the diet has negative effects on gut and liver health of common carp and disrupts intestinal microbiota.
AQUACULTURE REPORTS
(2021)
Article
Multidisciplinary Sciences
Qianwen Ding, Zhen Zhang, Yu Li, Hongliang Liu, Qiang Hao, Yalin Yang, Einar Ringo, Rolf Erik Olsen, Jihong Liu Clarke, Chao Ran, Zhigang Zhou
Summary: Propionate induces intestinal damage in zebrafish fed a high-fat diet, associated with oxidative stress and Sod2 propionylation. Sirt3 plays a crucial role in regulating Sod2 activity by modulating de-propionylation, leading to intestinal oxidative stress and changes in gut microbiota composition. This study highlights the potential mechanism of intestinal problems related to high propionate levels in zebrafish.
Article
Fisheries
Signe Dille Lovmo, Paul Whatmore, Henrik Sundh, Trygve Sigholt, Angelico Madaro, Tora Bardal, Rolf Erik Olsen
Summary: This study investigates the dietary needs and benefits of highly unsaturated fatty acids (HUFA) for Atlantic salmon, finding that a low HUFA diet can sustain growth and intestinal health under controlled conditions but is impaired after chronic stress. Increasing levels of EPA and DHA can strengthen the intestinal barrier response to chronic stress.
Article
Biotechnology & Applied Microbiology
Jerome Schmeisser, Viviane Verlhac-Trichet, Angelico Madaro, Santosh P. Lall, Ole Torrissen, Rolf Erik Olsen
Summary: The transcriptomic analysis revealed that pyloric caeca in post-smolt Atlantic salmon is more sensitive to dietary astaxanthin supplementation compared to hepatic and muscular tissues. Key genes sensitive to astaxanthin supplementation were identified in pylorus, liver, and muscle. The modulation of genes in pylorus was related to absorption and metabolism of astaxanthin, while liver showed a potential link to the ferroptosis process. Dietary astaxanthin had a lesser impact on muscle except for genes related to actin remodelling and glucose homeostasis.
MARINE BIOTECHNOLOGY
(2021)
Article
Fisheries
Mingxu Xie, Wei Zhou, Yadong Xie, Yu Li, Zhen Zhang, Yalin Yang, Rolf Erik Olsen, Chao Ran, Zhigang Zhou
Summary: The study showed that replacing fish meal with plant proteins may have negative effects on the gut and liver health of fish, while the fermentation product of C. somerae XMX-1 can improve the gut and liver health of fish and reduce liver fat deposition.
Article
Fisheries
R. Magalhaes, N. Martins, F. Fontinha, S. Moutinho, R. E. Olsen, H. Peres, A. Oliva-Teles
Summary: The study found limited interactions between arachidonic acid (ARA) or docosahexaenoic acid (DHA) and dietary digestible carbohydrates, while the starch content in the diet had a certain impact on the growth performance and feed utilization of gilthead sea bream.
Article
Fisheries
Mingxu Xie, Yadong Xie, Yu Li, Wei Zhou, Zhen Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhigang Zhou
Summary: Probiotics are widely used in aquafeeds to improve fish health and resistance to pathogens. This study examined the effects of a stabilized fermentation product of Cetobacterium somerae on zebrafish gut, liver health, and antiviral immunity. Results showed that the dietary supplement improved liver and gut health while enhancing antiviral immunity in zebrafish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Qianwen Ding, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhen Zhang, Zhigang Zhou
Summary: This study investigated the effects of docosahexaenoic acid (DHA) on fatty liver in zebrafish. The results showed that supplementation of DHA reduced hepatic lipid synthesis and promoted lipid beta-oxidation through Cyclin D1 inhibition. Furthermore, DHA facilitated lipid beta-oxidation through gut microbiota. These findings reveal the lipid-lowering effects of DHA and emphasize the importance of fatty acid composition in formulating high-fat diets for fish.
FRONTIERS IN NUTRITION
(2022)
Article
Fisheries
C. Klykken, A. K. Reed, A. S. Dalum, R. E. Olsen, M. K. Moe, K. J. K. Attramadal, L. Boissonnot
Summary: There is a growing concern for fish health and welfare in the salmon industry in Norway. The study found that nephrocalcinosis, characterized by mineral deposits in the kidneys, is common and varies in severity among Atlantic salmon. Most fish had mild forms of nephrocalcinosis with minimal tissue damage, while severely affected fish showed almost complete loss of kidney structure. Mineral deposits mainly consisted of amorphous carbonate apatite, and fish with nephrocalcinosis also exhibited imbalances in plasma chemistry, indicating disturbed osmoregulation and increased stress levels.
Article
Fisheries
Thomas W. K. Fraser, Tom J. Hansen, Sofie C. Remo, Rolf Erik Olsen, Per Gunnar Fjelldal
Summary: Interspecific hybridisation can improve the performance of sterile triploid salmonids, but it also leads to welfare issues, with only fillet coloration being improved.
Article
Fisheries
R. Magalhaes, N. Martins, F. Fontinha, A. Couto, C. R. Serra, R. A. Santos, E. Olsen, H. Peres, A. Oliva-Teles
Summary: The present study investigates the effects of different diet compositions on the oxidative status, histomorphology of liver and intestine, and intestinal microbiota modulation in gilthead sea bream juveniles. The results show that ARA-rich diets reduce liver and intestine lipid peroxidation, while DHA-rich diets increase the activity of antioxidant enzymes in the liver. Additionally, dietary starch improves the oxidative stress index in the liver and has positive effects on glutathione and lipid peroxidation in the intestine. Fish fed high starch diets also experience hepatocyte hypertrophy and alterations in nuclei position. Compared to DHA diets, ARA diets result in reduced diversity of intestinal microbiota. In conclusion, high dietary ARA provides protection to the liver and intestine of gilthead sea bream juveniles, and the balanced ratio of ARA/DHA in the diet has important effects on antioxidant status and intestinal microbiota diversity.
Article
Fisheries
Mingxu Xie, Qiang Hao, Rolf Erik Olsen, Einar Ringo, Yalin Yang, Zhen Zhang, Chao Ran, Zhigang Zhou
Summary: This study evaluated the effects of a stabilized fermentation product of Cetobacterium somerae (XMX-1) on the growth performance, gut, and liver health of common carp. The results showed that the addition of XMX-1 reduced serum lipopolysaccharide and diamine oxidase activity, increased intestinal total superoxide dismutase activity, and regulated the expression of certain genes. Furthermore, XMX-1 supplementation decreased serum alanine aminotransferase and liver triacylglycerol levels, and influenced the expression of genes related to liver lipid metabolism. L-XMX-1 at a level of 3 g/kg had the best effect on fish health.
AQUACULTURE REPORTS
(2022)
Article
Fisheries
Signe Dille Lovmo, Henrik Sundh, Paul Whatmore, Malene Fosse Nordvi, Trygve Sigholt, Angelico Madaro, Tora Bardal, Rolf Erik Olsen
Summary: The study found that feeding Atlantic salmon a high EPA diet improved intestinal health, while low HUFA fed fish had lower energy utilization. Chronic stress led to intestinal barrier damage and inflammation.
Article
Biochemistry & Molecular Biology
Peng Yin, Bjorn Thrandur Bjornsson, Per Gunnar Fjelldal, Takaya Saito, Sofie Charlotte Remo, Rolf Brudvik Edvardsen, Tom Hansen, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: Accumulating evidence suggests a close relationship between oxidative stress and growth rate in fish, but the underlying mechanisms are not clear. This study investigated the combined effect of dietary antioxidants and growth hormone (GH) on the redox status of liver and muscle in Atlantic salmon. The results show that GH implantation decreases vitamin C and E levels, increases oxidative stress in the liver, and affects the expression of genes and pathways related to antioxidant enzymes and redox balance. Dietary antioxidants do lower oxidative stress but have no effect on the growth rate.
Article
Biodiversity Conservation
Eirik Svendsen, Finn Okland, Martin Fore, Lise L. Randeberg, Bengt Finstad, Rolf E. Olsen, Jo A. Alfredsen
Summary: This study successfully adapted a PPG/ECG module to measure both ECG and PPG in-vivo for anesthetized Atlantic salmon. Using ECG as a baseline, PPG analysis results demonstrate that HR can be accurately estimated from PPG. Thus, PPG has the potential to become an alternative to ECG HR measurements in fish.
ANIMAL BIOTELEMETRY
(2021)
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.
