Article
Immunology
Huan Xia, Yitong Liu, Guiyang Xia, Yi Liu, Sheng Lin, Lijia Guo
Summary: The study identified a novel isoquinoline alkaloid LA from Litsea cubeba, which significantly inhibited the activation of inflammatory macrophages by modulating the NF-kappa B pathway. LA showed high selectivity and effective anti-inflammatory properties, making it a potential pharmacophore for developing novel agents to regulate local macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Anna Kieronska-Rudek, Agnieszka Kij, Patrycja Kaczara, Anna Tworzydlo, Marek Napiorkowski, Katarzyna Sidoryk, Stefan Chlopicki
Summary: Vitamins K have anti-inflammatory effects beyond coagulation, with shorter isoprenoid chain vitamins showing stronger potential and being preferred substrates for endogenous MK-4 synthesis, while statins inhibit endogenous MK-4 production. The anti-inflammatory activity of exogenous vitamins K is independent of endogenous MK-4 synthesis.
Article
Nutrition & Dietetics
Amanda Fernandes de Medeiros, Jaluza Luana Carvalho de Queiroz, Bruna Leal Lima Maciel, Ana Heloneida de Araujo Morais
Summary: Chronic low-grade inflammation is associated with obesity, and hydrolyzed proteins and plant peptides have shown potential anti-inflammatory and immunomodulatory effects. Understanding the mechanism of action of these molecules is important for their potential health applications.
Review
Food Science & Technology
Krishnapura Srinivasan
Summary: This review summarizes the available evidence for the anti-inflammatory potential of culinary spices or their bioactives. In vitro and animal studies have confirmed the anti-inflammatory effects of spices such as turmeric, chili, ginger, cloves, black seed, and black pepper. These effects may be achieved through the inhibition of inflammatory cytokines and transcription factors. The evidence strongly recommends a diet rich in specific anti-inflammatory spices to reduce inflammation and prevent inflammation-related diseases.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Plant Sciences
Ami Lee, You Chul Chung, Kwang Hoon Song, Jin Ah Ryuk, Hyunil Ha, Youth Hwan Hwang
Summary: The seeds of Psoralea corylifolia L. have been used in traditional oriental medicine to treat various diseases. This study found that the hydroethanolic extract of Psoralea corylifolia L. has therapeutic effects against inflammatory bowel disease in mice, and identified the bioactive components responsible for its anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Laura Grauso, Bruna de Falco, Giuseppe Lucariello, Raffaele Capasso, Virginia Lanzotti
Summary: Euphorbia myrsinites is an old species of spurges used in folk medicine, with a distribution in the Mediterranean region, Asia, and the USA. Research has identified various diterpenes in this species, including a new atisane diterpene with anti-inflammatory activity.
Review
Pharmacology & Pharmacy
Cigdem Yucel, Gokce Seker Karatoprak, Ozlem Bahadir Acikara, Esra Kupeli Akkol, Timur Hakan Barak, Eduardo Sobarzo-Sanchez, Michael Aschner, Samira Shirooie
Summary: Ginger is a popular spice and medicinal plant, containing phenolic compounds such as gingerols. Gingerols have antioxidant, anti-inflammatory, and immune-modulating properties. However, low bioavailability is a challenge, and new drug delivery systems have been developed to enhance the effectiveness of gingerols.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ambreen Ghani, Zubi Sadiq, Sadaf Iqbal, Abida Yasmeen, Shahida Shujaat, Iftikhar Ali
Summary: Inflammatory diseases are associated with life-threatening syndromes and a decrease in quality of life. Dinitro-tetrahydrocarbazole linked pyrazolines were synthesized and screened for their anti-inflammatory, antioxidant, and molecular docking activities. The disubstituted diazoles showed good membrane stabilizing effects and significant antioxidant potential. Molecular docking revealed a correlation between the anti-inflammatory activity of diazoles and the target enzymes involved in inflammation.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Energy & Fuels
Gizem Yildizli, Gokhan Coral, Furkan Ayaz
Summary: Wood vinegar demonstrates antimicrobial and antifungal activity, but lacks antibacteriophage activity. Additionally, it exhibits anti-inflammatory properties by reducing the production levels of pro-inflammatory cytokines by mammalian macrophage like cells.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Medicine, Research & Experimental
Xuzhuo Chen, Xiankun Cao, Dasheng Zheng, Chang Li, Yan Chen, Keyu Kong, Weifeng Xu, Bin Shi, Xinwei Chen, Fengrong Dai, Shanyong Zhang
Summary: In this study, PtAu2 nanoclusters with nitric oxide-responsive phosphorescence turn-on characteristics and strong binding interactions with cysteine were designed. They showed satisfactory biocompatibility and cellular uptake behavior, with potent anti-inflammatory and anti-osteoclast activities. Furthermore, PtAu2 clusters alleviated lipopolysaccharide-induced calvarial osteolysis in vivo and activated Nrf2 expression.
Article
Biology
Haruki Nishimura, Mitsuhiro Yoshimura, Makiko Shimizu, Kenya Sanada, Satomi Sonoda, Kazuaki Nishimura, Kazuhiko Baba, Naofumi Ikeda, Yasuhito Motojima, Takashi Maruyama, Yuki Nonaka, Ryoko Baba, Tatsushi Onaka, Takafumi Horishita, Hiroyuki Morimoto, Yasuhiro Yoshida, Makoto Kawasaki, Akinori Sakai, Masafumi Muratani, Becky Conway-Campbell, Stafford Lightman, Yoichi Ueta
Summary: The analgesic effect of oxytocin is mediated through its receptor and contributes to the anti-nociception and anti-inflammatory response. A transgenic rat line expressing hM3Dq and mCherry in oxytocin neurons was generated and demonstrated that oxytocin activates specific neurons and attenuates hyperalgesia. This analgesic effect is abolished by oxytocin receptor antagonist.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Medicinal
Belen Cuevas, Ana I. Arroba, Carolina de los Reyes, Laura Gomez-Jaramillo, M. Carmen Gonzalez-Montelongo, Eva Zubia
Summary: A chemical study of the brown alga Rugulopteryx okamurae led to the isolation of ten new diterpenoids, with compound 1 and secospatanes 5 and 10 showing significant inhibitory effects in anti-inflammatory assays. These compounds have potential biomedical applications in inflammation-related research.
Article
Agriculture, Multidisciplinary
Xiaoyang Zhou, Pingping Shen, Wei Wang, Jing Zhou, Richa Raj, Zhichao Du, Shaohua Xu, Weiwei Wang, Boyang Yu, Jian Zhang
Summary: Microbial transformation of soyasapogenol A led to the isolation of 10 novel and 1 reported metabolites, showing potent anti-inflammatory activity. The structures were elucidated using 1D/2D NMR and HR-ESI-MS methods, and the bioassay results indicated the potential of these compounds as anti-inflammatory food supplements derived from soybeans.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Noelia Florez-Fernandez, Arianna Rodriguez-Coello, Thomas Latire, Nathalie Bourgougnon, M. Dolores Torres, Manuela Bujan, Alexandra Muinos, Antonio Muinos, Rosa Meijide-Failde, Francisco J. Blanco, Carlos Vaamonde-Garcia, Herminia Dominguez
Summary: Ulvans, sulfated polysaccharides found in green seaweeds, have interesting anti-inflammatory properties. However, their composition and properties vary greatly depending on seaweed species and processing conditions. This review emphasizes the importance of appropriate extraction, depolymerization, and purification techniques for reproducible and well-characterized products. Ulvans can modulate different signaling pathways to exert anti-inflammatory effects and have potential applications in various diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Christian D. Ortiz-Robles, Vanessa Cortes-Montoya, Sandra S. Reyes-Aguilar, Arnulfo Albores, Emma S. Calderon-Aranda
Summary: Lead exposure alters functional outcomes and phenotypic markers of macrophages, especially the anti-inflammatory phenotype, with effects on specific pathways differing between inflammatory and anti-inflammatory cells.
Article
Polymer Science
Mehmet Ulasan, Emine Yavuz, Yunus Cengeloglu, Mustafa Selman Yavuz
Meeting Abstract
Biotechnology & Applied Microbiology
Emine Yavuz, Emin Umit Bagriacik
JOURNAL OF BIOTECHNOLOGY
(2017)
Article
Engineering, Biomedical
Mehmet Ulasan, Emine Yavuz, Emin Umit Bagriacik, Yunus Cengeloglu, Mustafa Selman Yavuz
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2015)
Article
Biotechnology & Applied Microbiology
Mustafa Ulker, A. C. Tutku Celik, Emine Yavuz, Firdevs Kahvecioglu, H. Esra Ulker
Summary: The cytotoxic responses of six different over-the-counter mouthwashes on L929 cells were analyzed using traditional MTT assay and modern RTCA system. The results showed that mouthwash containing alcohol was the most biocompatible, while those containing sodium fluoride and cetylpyridinium chloride had the most cytotoxic effects on cells.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Immunology
Fatma Secer Celik, Canan Eroglu Gunes, Emine Yavuz, Ercan Kurar
Summary: Cancer is the second leading cause of death worldwide after cardiovascular diseases. Chemotherapy, radiotherapy and surgical interventions are the current treatment approaches for cancer. Recent studies have shown that immunotherapeutic approaches can significantly improve the effectiveness of these interventions. The mono-nuclear system, mainly consisting of macrophages, plays an active role in the development of many diseases and has the potential to be used as an alternative treatment for cancer.
Article
Chemistry, Multidisciplinary
Sami Dursun, Emine Yavuz, Zeynep Cetinkaya
Meeting Abstract
Biochemistry & Molecular Biology
E. Yavuz, S. Dinc, M. Kara, E. U. Bagriacik
Proceedings Paper
Nanoscience & Nanotechnology
E. Yavuz, E. U. Bagriacik
PROCEEDINGS OF THE 2017 IEEE 7TH INTERNATIONAL CONFERENCE NANOMATERIALS: APPLICATION & PROPERTIES (NAP)
(2017)
Meeting Abstract
Immunology
E. Yavuz, H. Sakalak, H. Cavusoglu, P. Uyar, M. S. Yavuz, E. U. Bagriacik
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
E. Yavuz, H. Sakalak, H. Cavusoglu, P. Uyar, M. S. Yavuz, E. U. Bagriacik
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Ekrem Goren, Halit Cavusoglu, Emine Yavuz, Hakan Usta, Murat Citir, Mustafa Selman Yavuz
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Emine Yavuz, Mehmet Ulasan, Halit Cavusoglu, Yunus Cengeloglu, Mustafa Selman Yavuz
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Meeting Abstract
Chemistry, Multidisciplinary
Ekrem Goren, Halit Cavusoglu, Emine Yavuz, Hakan Usta, Mustafa Selman Yavuz
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Meeting Abstract
Chemistry, Multidisciplinary
Mehmet Ulasan, Emine Yavuz, Emin Umit Bagriacik, Yunus Cengeloglu, Mustafa Selman Yavuz
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)