期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 104, 期 6, 页码 2319-2331出版社
SPRINGER
DOI: 10.1007/s00253-020-10348-x
关键词
Bacillus subtilis; Spores; Surface display; Coat protein
资金
- National Natural Science Foundation of China [31501413]
- Shandong key project of Research & Development plan [2017GSF221019]
- Young doctorate Cooperation Fund Project, QiLu University of Technology (Shandong Academy of Sciences) [2017BSHZ021]
- State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences [ZZ20190314]
- Natural Science Foundation of Shandong Province [ZR2017BC072, ZR2019PC060]
- Dragon City Excellent Researcher Award Program from Zhucheng and Taishan Industry Leading Talents Program
- Project of Shandong Province Higher Educational Science and Technology Program [A18KA116]
Bacillus subtilis is a widely distributed aerobic Gram-positive species of bacteria. As a tool in the lab, it has the advantages of nonpathogenicity and limited likelihood of becoming drug resistant. It is a probiotic strain that can be directly used in humans and animals. It can be induced to produce spores under nutrient deficiency or other adverse conditions. B. subtilis spores have unique physical, chemical, and biochemical characteristics. Expression of heterologous antigens or proteins on the surface of B. subtilis spores has been successfully performed for over a decade. As an update and supplement to previously published research, this paper reviews the latest research on spore surface display technology using B. subtilis. We have mainly focused on the regulation of spore coat protein expression, display and application of exogenous proteins, and identification of developing research areas of spore surface display technology.
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