期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 104, 期 5, 页码 1883-1890出版社
SPRINGER
DOI: 10.1007/s00253-019-10333-z
关键词
C-glycosides; C-C glycosidic bond; Puerarin; Deglycosylation; Intestinal bacteria
资金
- National 111 Project [No. D17012] Funding Source: Medline
- National Natural Science Foundation of China [81741165, 81773628] Funding Source: Medline
- National Key Research and Development Program of China [2017YFE0103100] Funding Source: Medline
C-Glycosides, a special type of glycoside, are frequently distributed in many kinds of medicinal plants, such as puerarin and mangiferin, showing various and significant bioactivities. C-Glycosides are usually characterized by the C-C bond that forms between the anomeric carbon of sugar moieties and the carbon atom of aglycon, which is usually resistant against acidic hydrolysis and enzymatic treatments. Interestingly, C-glycosides could be cleaved by several intestinal bacteria, but whether the enzymatic cleavage of C-C glycosidic bond is reduction or hydrolysis has been controversial; furthermore, whether existence of a C-glycosidase directly catalyzing the cleavage is not clear. Here we review research advances about the discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bond with an emphasis on the identification of enzymes manipulation the deglycosylation. Finally, we give a brief conclusion about the mechanism of C-glycoside deglycosylation and perspectives for future study in this field.
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